Kit for predicting Chinese leukocyte antigen genotype using single nucleotide polytype

A technology of single nucleotide polymorphism and antigen gene, which is applied to the determination/testing of microorganisms, biochemical equipment and methods, etc., which can solve the problem that the model cannot use the leukocyte antigen genotype and the distribution of human leukocyte tissue antigen gene categories is different And other issues
CN104109710BInactive Publication Date: 2018-02-09ACAD SINIC +2
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
ACAD SINIC
Publication Date
2018-02-09
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a kit for predicting leukocyte antigen genotypes of the Han people by using single-nucleotide polymorphisms and applications thereof. Models are predicted for the human leukocyte antigen genotypes (HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQB1 and HLA-DRB1) of the Asians, and the prediction results achieve optimization of the models. The typical human leukocyte antigen alleles types of the Asians are predicted according to the fixed genotypes of the single-nucleotide polymorphisms with a high accuracy ranging from 80.37% (HLA-B) to 95.79% (HLA-DQB1). Besides, the kit for predicting the leukocyte antigen alleles types by using the genotypes can save a considerable amount of time and cost.
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Description

technical field

[0001] The present invention relates to a kit for predicting human leukocyte antigen alleles with single nucleotide polymorphisms with ethnic specificity, in particular, the present invention relates to using single nucleotide polymorphisms of Han Chinese to predict human leukocyte antigens Antigen Genotyping Kit. Background technique

[0002] The human leukocyte tissue antigen gene group is located on the sixth pair of chromosomes and is divided into major histocompatibility complex class I (HLA-A, HLA-B, and HLA-C) and major histocompatibility complex class II (HLA -DR, HLA-DQ, and HLA-DP) alleles, and the polymorphism (polymorphism) pattern of multiple alleles of a single gene in an individual causes graft rejection (graft) during tissue or organ transplantation rejection) and graft-versus-host diseases. HLA alleles also play important roles in population genetics and immune-related disease status. Furthermore, previous comparative studies have shown th...

Claims

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