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Atorvastatin calcium compound

A technology of atorvastatin calcium and a composition, applied in the field of medicine, can solve the problems of high total amount of impurities, difficult to repeat crystal form, large number of impurities of atorvastatin calcium trihydrate and the like

Active Publication Date: 2015-02-25
TIANJIN HANRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the research process, repeating the method of the above literature, the obtained atorvastatin calcium trihydrate has more impurities, the total amount of impurities is higher, and the crystal form is difficult to repeat after amplification.

Method used

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  • Atorvastatin calcium compound
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The X-ray diffraction pattern of the crystal is shown in figure 1 . Instrument model and measurement conditions: Rigaku D / max 2500 diffractometer; CuKa 40Kv 100mA; 2θ scanning range: 0-50 ° .

[0046] Example 2

Embodiment 2

[0048] The X-ray diffraction figure that measures is the same as the X-ray diffraction figure of embodiment 1 ( figure 1 ).

[0049] Example 3

Embodiment 3

[0051] The X-ray diffraction figure that measures is the same as the X-ray diffraction figure of embodiment 1 ( figure 1 ).

[0052] Example 4

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Abstract

The invention belongs to the technical field of medicine, and specifically relates to an atorvastatin calcium trihydrate compound and a preparation method thereof. The invention also relates to a pharmaceutical composition containing the provided atorvastatin calcium trihydrate compound and an application of the pharmaceutical composition in preparation of drugs for treating dyslipidemia diseases such as primary hypercholesterolemia, hypertriglyceridemia, familial hypercholesterolemia, mixed hyperlipidemia, and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to atorvastatin calcium trihydrate and a preparation method thereof. The invention also relates to the use of this crystal to manufacture and treat primary hypercholesterolemia, hypertriglyceridemia, and Application in drugs for various types of dyslipidemia such as cholesterolemia and mixed hyperlipidemia. Background technique [0002] Atherosclerosis (Atherosclemsis, AS) is an important pathological basis of most cardiovascular and cerebrovascular diseases. With the continuous research on hyperlipidemia and the accumulation of comprehensive treatment experience, the types of drugs for treating hyperlipidemia and their usage are also constantly changing. 3-Hydroxy-3-methylglutaryl-CoA ( HMG-CoA) reductase inhibitors, referred to as statins, are considered to be the most classic and effective modulators due to their novel mechanism of action, wide range of applications,...

Claims

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Application Information

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IPC IPC(8): C07D207/34A61K31/40A61P3/06
CPCC07D207/34
Inventor 严洁李轩
Owner TIANJIN HANRUI PHARMA
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