Method and mold for injection molding production of various polymer biochip substrates

Abstract

The invention relates to an injection molding production method and an injection molding production mould of multiple polymer biological chip substrates. The method comprises the steps of carrying out combined processing on a circular electroforming nickel plate and a circular mirror board in advance, and punching to manufacture a mold core, wherein the circular electroforming nickel plate has the diameter of 150mm and the thickness within the range of 0.3-6mm and is manufactured by an ultra-violet lithography (UV-LIGA) technology, and the circular mirror board has the diameter of 150mm and the thickness within the range of 6-11.7mm; or punching a circular mold core which has the diameter of 150mm and the thickness of 12mm and is processed by electric spark or ultrasonic electrolysis to manufacture another mold core. The two mold cores can be installed on a mould in a matching way by corresponding accessories, and the injection molding production of the polymer biological chip substrates with different outer diameters, inner diameters, thicknesses or grooves can be realized by replacing the mold cores and / or the accessories, so that the injection molding production of the polymer biological chip substrates with different outer diameters, inner diameters, thicknesses and grooves can be realized, the production cost is effectively lowered, and the laboratory experiment requirements and industrialization development of biological chips are promoted.

Description

technical field [0001] The invention relates to the field of injection molding production of polymer biochip substrates, in particular to methods and molds for injection molding production of various polymer biochip substrates. Background technique [0002] At present, biochip substrates produced by injection molding with polymer materials (mainly including PC, PMMA, and COP materials) can be roughly divided into the following two types: [0003] The first is to use the DVD disc injection molding production process (UV-Liga technology) to produce an electroformed biochip master with a thickness of 300um and a diameter of about 150mm with micro-nano structure channels on the biochip substrate, and install the master on On the mold of the CD injection molding machine, a circular biochip substrate with a micro-nano structure is injected, with a diameter range of 120mm and a thickness of 0.6mm-1.2mm. If it is a circular biochip substrate or cover sheet, injection molding is requ...

AI Technical Summary

Problems solved by technology

However, the disadvantage of using this method to produce biochip substrates is that only a 300um thick electroformed master can be installed on the DVD disc injection mold, and the outer diameter of the injection molded parts of the substrate and cover can only be within 120mm. The strength of the matrix of the master plate is not enough, and the master plate with deep grooves is easily deformed when it is installed on the injection molding machine for injection molding, or the thickness of the master plate is 300um in terms of structural strength.

This method is suitable for the production of large-scale biochip substrates of a single variety. It cannot quickly replace the mold core, cannot realize the rapid conversion of biochip injection varieties, and cannot process the micro-nano structure of the channel.

The cost of mold manufacturing is high and the processing cycle is long

The mold does not have the function of quick replacement of the mold core, and the production cost of small batches of biochip substrates is high. When machining the mold core, the precision of the processing equipment is high, and it is difficult to achieve non-planar mirror polishing during machining.

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