Biomarkers of Renal Dysfunction

Abstract

The present invention relates to a method for predicting the development of renal dysfunction in a subject following physical trauma, hypotension, sepsis and/or septic shock syndrome, wherein said method comprises the steps of: a. Levels of anti-inflammatory cytokines present in samples taken from the subject after trauma, after a hypotensive event, after sepsis, and/or after septic shock syndrome; b. based on the anti-inflammatory cytokines determined in step a) Said level of a factor predicts the development of renal dysfunction in said subject.

Description

technical field [0001] The present invention relates to methods for predicting the development of renal dysfunction, and to kits for making such predictions. Background technique [0002] Physical Trauma In addition to direct negative effects on the body (such as damage caused by surgery or car crashes, or damage caused by surgical procedures such as blood bypass by cardio-pulmonary machinery), subjects who suffer physical trauma often Development of acute renal dysfunction. Other causes of similar acute renal dysfunction include prolonged hypotensive states (eg associated with intestinal mucosal ischemia and translocation of endotoxin from the gut to the circulatory system), sepsis and septic shock syndrome. [0003] In a population of patients with normal renal function, posttraumatic, hypotension-induced, sepsis-induced, and / or sepsis-induced Diagnosis of renal dysfunction induced by hemorrhagic shock syndrome; as measured eg by the MDRD test (explained further below). ...

AI Technical Summary

Problems solved by technology

A limitation of diagnosis or prognosis based on these measures is that i

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