Antitrichophytosis solution for external use

Abstract

A topical liquid agent for a nail and / or skin for prevention or treatment of dermatophytosis comprises a film-forming agent and a compound represented by the formula: wherein R1 represents hydrogen, C1-6 alkyl, or trifluoromethyl, R2 represents hydrogen, C1-6 alkyl, halogen, -COO(C1-6 alkyl), or (CH2)1-3COOR where R represents hydrogen or C1-6 alkyl, R3 represents hydrogen, C1-6 alkyl, amino, trifluoromethyl, or OR where R represents hydrogen or C1-6 alkyl, R4 represents hydroxyl, R5 represents hydrogen, C1-6 alkyl, hydroxyl, or halogen, R6 represents hydrogen, C1-6 alkyl, trifluoromethyl, halogen, amino, -NRaRb, nitro, hydroxy-C1-6 alkyl, -CONRaRb, -COO(C1-6 alkyl), -COOH, -(CH2)1-3COOR, or ORa where R represents hydrogen or C1-6 alkyl, Ra and Rb each represent hydrogen, C1-6 alkyl, or C1-6 acyl, R7 represents hydrogen, C1-6 alkyl, -OR where R represents hydrogen or C1-6 alkyl, or halogen, R8 represents hydrogen, C1-6 alkyl, hydroxyl, amino, or nitro, or a salt thereof.

Description

technical field [0001] The present invention relates to the use of novel 2-(1H-pyrazol-1-yl)phenol derivatives or pharmaceutically acceptable salts thereof suitable as anti-phytonids as active ingredients for the prevention or treatment of trichophytosis Therapeutic topical solution. Background technique [0002] Mycosis is a disease that results from the infection of humans or animals by fungi. Representative mycoses in humans include candidiasis caused by Candida, cryptococcosis caused by Cryptococcus, aspergillosis caused by Aspergillus, zygomycosis caused by Zygomycetes, and leukocytosis. Skin filamentous mycosis (tinea versicolor) etc. caused by ringworm (pathogenic fungi and mycosis (Nan Shantang, revised 2nd edition), p42-45; non-patent literature 1). [0003] Trichophyton, which is one of the pathogenic bacteria of mycosis, is a skin filamentous fungus that causes tinea versicolor, and has the property of keratolytic ability. Through this ability, it can invade th...

AI Technical Summary

Problems solved by technology

[0011] However, in these prior art documents, none of the compounds with 2-(1H-pyrazol-1-yl)phenol skeleton are suggested and disclosed to be related to anti-phytonid activity

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