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Zirconium dioxide composite nanomaterial with microwave sensitization, slow and controlled release of chemotherapy drugs and CT imaging functions, preparation method and application

A technology of composite nanomaterials and zirconia, which is applied in the field of zirconia composite nanomaterials and its preparation, can solve the problems of few tumor chemotherapy effects and mechanisms, no chemotherapy functions, etc., and achieve good clinical application value and good microwave amplification. Sensitive performance, good temperature rise performance

Inactive Publication Date: 2017-12-15
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biological safety of the inner core ionic liquid used in this patent needs to be further verified. The composite structure has two functions of CT imaging and microwave hyperthermia, but does not have the function of chemotherapy. There are still few studies on the mechanism, especially the functions of microwave sensitization and CT enhancement have not been reported

Method used

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  • Zirconium dioxide composite nanomaterial with microwave sensitization, slow and controlled release of chemotherapy drugs and CT imaging functions, preparation method and application
  • Zirconium dioxide composite nanomaterial with microwave sensitization, slow and controlled release of chemotherapy drugs and CT imaging functions, preparation method and application
  • Zirconium dioxide composite nanomaterial with microwave sensitization, slow and controlled release of chemotherapy drugs and CT imaging functions, preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034](1) Disperse Huaier polysaccharide in a mixed solution of deionized water and absolute ethanol (volume ratio 1:1), with a mass volume fraction of 1%, and disperse evenly by ultrasonication or stirring;

[0035] (2) Add hollow zirconia composite nanomaterials to the Huaier polysaccharide aqueous solution obtained in step 1), the concentration is 5 mg mL -1 , realize Huaier polysaccharide encapsulation by negative pressure filling method;

[0036] (3) Wash the hollow zirconia composite nanomaterial wrapped with Huaier polysaccharide obtained in step 2) with deionized water until the supernatant is clear and transparent, that is, it has the functions of microwave sensitization, slow and controlled release of chemotherapeutic drugs, and CT imaging. Hollow zirconia composite nanomaterials coated with Huaier polysaccharide.

[0037] from Figure 1-3 It can be clearly observed that the obtained hollow zirconia composite nanomaterials are uniformly distributed, the particle si...

Embodiment 2

[0043] (1) Disperse Huaier polysaccharide in deionized water and 1,4-dioxane mixed solution (volume ratio 1:1), with a mass volume fraction of 10%, and disperse evenly by ultrasonication or stirring;

[0044] (2) Add hollow zirconia composite nanomaterials to the Huaier polysaccharide aqueous solution obtained in step 1), and the concentration is 10mg mL -1 , realize Huaier polysaccharide encapsulation by negative pressure filling method;

[0045] (3) Wash the hollow zirconia composite nanomaterial wrapped with Huaier polysaccharide obtained in step 2) with deionized water until the supernatant is clear and transparent, that is, it has the functions of microwave sensitization, slow and controlled release of chemotherapeutic drugs, and CT imaging. Hollow zirconia composite nanomaterials coated with Huaier polysaccharide.

[0046] The hollow zirconia composite nanomaterial coated with Huaier polysaccharide prepared in this example was used in microwave hyperthermia technology f...

Embodiment 3

[0051] (1) Disperse Huaier polysaccharide in deionized water with a mass volume fraction of 30%, and disperse evenly by ultrasonication or stirring;

[0052] (2) Add hollow zirconia composite nanomaterials to the Huaier polysaccharide aqueous solution obtained in step 1), and the concentration is 100mg mL -1 , realize Huaier polysaccharide encapsulation by negative pressure filling method;

[0053] (3) Wash the hollow zirconia composite nanomaterial wrapped with Huaier polysaccharide obtained in step 2) with deionized water until the supernatant is clear and transparent, that is, it has the functions of microwave sensitization, slow and controlled release of chemotherapeutic drugs, and CT imaging. Hollow zirconia composite nanomaterials coated with Huaier polysaccharide.

[0054] The hollow zirconia composite nanomaterial coated with Huaier polysaccharide prepared in this example was used in microwave hyperthermia technology for tumors. The in vitro and in vivo microwave heat...

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Abstract

The invention discloses a zirconium dioxide composite nanometer material with microwave sensitization, chemotherapy dry release and CT imaging functions and a preparation method and application thereof. The zirconium dioxide composite nanometer material comprises a hollow zirconium dioxide nanometer material and trametes polysaccharide. The hollow part of the zirconium dioxide nanometer material of the zirconium dioxide composite nanometer material is filled with the trametes polysaccharide. The grain size of the zirconium dioxide composite nanometer material is 50-500 nm; the thickness of a shell is 10-100 nm. The prepared zirconium dioxide composite nanometer material is good in dispersity; the size and thickness of the shell can be adjusted as needed. The hollow part of the zirconium dioxide is filled with the traditional Chinese medicine trametes polysaccharide with the chemotherapy effect for the first time; the zirconium dioxide composite nanometer material can be applied to the technical fields of microwave sensitization, chemotherapy dry release and CT imaging at the same time, achieves the target of treating the tumor through the diagnosis and treatment integration and targeted hyperthermia chemotherapy and has good clinical application prospects.

Description

technical field [0001] The invention relates to the application of zirconia composite nanometer material and technology in cancer diagnosis and treatment. More specifically, it relates to a zirconia composite nanomaterial with the functions of microwave sensitization, slow and controlled release of chemotherapy drugs and CT imaging, its preparation method and application. Background technique [0002] Cancer has become the leading cause of death worldwide. According to the World Cancer Report 2014 by the World Health Organization, there were more than 14 million new cancer cases worldwide in 2012, which will reach 19 million by 2025, and will exceed 24 million by 2035. The report also shows that developing countries in Africa, Asia, and Central and South America have the most serious cancer incidence. The incidence of malignant tumors in my country is also rising. In 2012, there were 3.07 million new cancer patients and about 2.2 million people died of cancer, accounting f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/04A61K31/715A61K49/04A61P35/00
CPCA61K9/0002A61K9/10A61K9/5115A61K31/715A61K41/0052A61K49/0423A61K2300/00
Inventor 邵海波牛猛马腾闯徐克
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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