A kind of self-microemulsion soft capsule of ginseng hydrolyzate ppt/ppd and preparation method thereof

Abstract

The invention discloses a self-microemulsion soft capsule of ginseng hydrolysate PPT (protopanoxadiol) / PPD (protopanaxatriol) and a preparation method of the self-microemulsion soft capsule, and belongs to the technical field of a pharmaceutical preparation. Contents of the self-microemulsion soft capsule of ginseng hydrolysate PPT / PPD include ginseng hydrolysate PPT / PPD and pharmaceutical adjuvants, wherein the mass ratio of the ginseng hydrolysate PPT / PPD to the pharmaceutical adjuvants is at 1 to (6-21); the pharmaceutical adjuvants include an oil phase, an emulsifier and a co-emulsifier; the oil phase, the emulsifier and the co-emulsifier are respectively Miglyol oil, Labrasol and Tween-20, and the mass ratio of the oil phase to the emulsifier to the co-emulsifier is at (1-2) to (4-8) to (1-5). The preparation method of the self-microemulsion soft capsule comprises the following steps: uniformly mixing the ginseng hydrolysate PPT / PPD and the pharmaceutical adjuvant, uniformly dispersing and filling an obtained mixture in a soft capsule so as to obtain the self-microemulsion soft capsule. By virtue of the pharmaceutical adjuvants which have CYP450 inhibitory activity, the self-microemulsion soft capsule of ginseng hydrolysate PPT / PPD disclosed by the invention is capable of improving the oral bioavailability of the PPT / PPD.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract preparation and a preparation method thereof, in particular to a ginseng hydrolyzate PPT / PPD self-microemulsion capsule preparation prepared with a pharmaceutical excipient having CYP450 inhibitory activity and a preparation method thereof, belonging to the technical field of pharmaceutical preparations . Background technique [0002] Ginseng is the dried root of Panax ginseng C.A.Mey, a traditional Chinese medicine. It has the functions of invigorating vital energy, recovering veins and strengthening the spleen, nourishing the spleen and lungs, promoting body fluid, and calming the nerves. So far, the chemical components of ginseng that have been elucidated include saponins, polysaccharides, polyacetylenic alcohols, amino acids, and volatile oils. Among them, saponins are the most important kind of physiologically active substances in ginseng, and most of their structures belong to damm...

AI Technical Summary

Problems solved by technology

PPT / PPD is a traditional Chinese medicine preparation with a potential market. The pharmacodynamic results show that it has a significant protective effect on cognitive function damage, but because it will be metabolized by intestinal CYP450 after oral administration, it will lead to the highest content of the main component PPT. Oral bioavailability is low, how to effectively improve the oral bioavailability of such drugs has become a research topic for researchers

Images