Application of astragalus saponin I to treating osteoporosis

An osteoporosis and astragalus saponin technology is applied in the application field of astragaloside I in the treatment of osteoporosis, and achieves the effects of promoting osteoblast differentiation, treating osteoporosis and inhibiting osteoclast differentiation

Inactive Publication Date: 2016-03-23
HUBEI UNIV
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  • Application Information

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Problems solved by technology

Including acetyl astragaloside I, astragaloside I~VIII, isoastragloside I~II, astragaloside B, cycloastragenol and soybean saponin I, etc. Studies have shown that Astragalus extract has anti-osteoporosis effects, but which specific The effect of a monomeric compound has not been reported

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  • Application of astragalus saponin I to treating osteoporosis
  • Application of astragalus saponin I to treating osteoporosis
  • Application of astragalus saponin I to treating osteoporosis

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Embodiment Construction

[0026] The first aspect of the present invention provides the application of astragaloside I in the preparation of medicine for treating osteoporosis. The traditional Chinese medicine Astragalus membranaceus has the ability to resist osteoporosis, but the astragalus membranaceus monomer with medicinal effect is unknown. After research by the inventor, it is clear that astragalus saponin I is the astragalus membranaceus monomer with the ability to resist osteoporosis. I provides a new idea for the basic development of new drugs to treat the disease.

[0027] Specifically, the drug is a drug for treating osteoporosis that promotes osteoblast differentiation. The effects of different concentrations of astragaloside I on the proliferation rate and early differentiation of MC3T3-E1 cells were examined at different time points in the early stage by cell proliferation rate test (MTT) and alkaline phosphatase (ALP) activity detection. After confirming the effect of astragaloside I on...

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Abstract

The invention provides application of astragalus saponin I to preparing dug for treating osteoporosis. Monomer compounds of astragalus saponin I (namely As-I) which can promote osteoblast differentiation are screened from traditional Chinese medicine astragalus, the osteogenic differentiation promoting function of astragalus saponin I is comprehensively verified, it is definite that astragalus saponin I has the effect of improving the expression level of bone formation key factors of Runx2, BMP-2, BGP and beta-catenin through a Wnt pathway, and therefore osteoblast differentiation is promoted; astragalus saponin I can down-regulate the RANKL/OPG expression ratio so that osteoclast differentiation can be inhibited, the purpose of treating osteoporosis is further achieved, and astragalus saponin I has great significance in osteoporosis treatment. Astragalus saponin I serves as a basis and is compounded with pharmaceutic adjuvants to form medicine for treating osteoporosis, and a new idea is provided for treating the disease.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of astragaloside I in the treatment of osteoporosis. Background technique [0002] Osteoporosis, or OP, is a disease characterized by decreased bone mass, decreased bone density, and loss of bone-related proteins, which in turn lead to an increased risk of fracture in patients. Seriously affect the quality of life of patients. Osteoporosis mostly occurs in the elderly. With the aging of the world's population, osteoporosis has gradually become a public health issue of concern in my country and the world. It is urgent to develop new drugs for the treatment of osteoporosis. [0003] There are also many drugs currently used clinically for the treatment of OP, mainly including three categories. The first category is anti-resorptive drugs, such as bisphosphonates, calcitonins, selective estrogen receptor modulators (SERMs) and Estrogens. The second cat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P19/10
CPCA61K31/7048
Inventor 孙丽娟程寻胡小芳韩凤梅陈勇
Owner HUBEI UNIV
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