A preparation method and quality control method of Duhuo Jisheng Decoction formula granules

A technology of Duhuoji decoction and formula granules, which can be used in pharmaceutical formulas, medical preparations containing active ingredients, measuring devices, etc., and can solve problems such as lack of quality standards

Active Publication Date: 2019-11-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, due to the relatively little research on compound formula granules and the lack of current quality standards in the industry, it is necessary to study a perfect quality standard to ensure the safety, effectiveness and controllable quality of the product

Method used

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  • A preparation method and quality control method of Duhuo Jisheng Decoction formula granules
  • A preparation method and quality control method of Duhuo Jisheng Decoction formula granules
  • A preparation method and quality control method of Duhuo Jisheng Decoction formula granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] A preparation method of Duhuojijietang formula granules includes the following steps:

[0081] a. Take Solanum esculentum 60g, Morus albus 40g, Eucommia 40g, Achyranthes 40g, Asarum 40g, Gentiana 40g, Poria 40g, Cinnamon 160g, Parsnip 200g, Ligusticum chuanxiong 200g, Ginseng 200g, Licorice 200g, Angelica 200g, White Peony 200g, Rehmannia glutinosa 200g, the volatile oils of Radix Serrata, Asarum, Guizhi, Fangfeng, Ligusticum chuanxiong and Angelica are distilled to make β-cyclodextrin inclusion compound by β-cyclodextrin inclusion compound. The amount of β-cyclodextrin added is equal to that of volatile oil. The mass ratio is 6:1;

[0082] b. Herbal dregs, Asarum, Guizhi, Fangfeng, Ligusticum chuanxiong and Angelica extract volatile oil and the remaining 9 flavors add 18.6kg of water, decoct and extract for 1.5 hours, that is, one decoction; after one decoction, add 14.88kg of the medicine residue Decoction in water for 1 hour, that is, second decoction;

[0083] c. Combine...

Embodiment 2

[0087] A preparation method of Duhuojijietang formula granules includes the following steps:

[0088] a. Take the sylvestris 200g, Morus alba 180g, Eucommia 180g, Achyranthes 180g, Asarum 180g, Gentiana 180g, Poria 120g, Cinnamon 80g, Parsnip 80g, Chuanxiong 80g, Ginseng 80g, Licorice 80g, Angelica 80g, White Peony 80g, Rehmannia glutinosa 80g, the volatile oils of Radix Serrata, Asarum, Guizhi, Fangfeng, Ligusticum chuanxiong and Angelica are distilled to make β-cyclodextrin inclusion compound by β-cyclodextrin inclusion compound. The amount of β-cyclodextrin added is equal to that of volatile oil. The mass ratio is 4:1;

[0089] b. Herbal dregs, Asarum, Guizhi, Fangfeng, Ligusticum chuanxiong and Angelica extract volatile oil and the remaining 9 flavors add 18.6kg of water, decoct and extract for 1.5 hours, that is, one decoction; after one decoction, add 14.88kg of the medicine residue Decoction in water for 1 hour, that is, second decoction;

[0090] c. Combine the two decoctio...

Embodiment 3

[0096] A preparation method of Duhuojijietang formula granules includes the following steps:

[0097] a. Take 220g of Lilac, 200g of Mulberry, 200g of Eucommia, 200g of Achyranthes 200g, 200g of Asarum, Gentiana 200g, Poria 120g, Cinnamon 100g, Parsnip 60g, Ligusticum chuanxiong 60g, Ginseng 60g, Licorice 60g, Angelica 60g, White Peony 60g, Rehmannia glutinosa 60g, the volatile oil of Radix Serrata, Asarum, Guizhi, Fangfeng, Ligusticum chuanxiong and Angelica are distilled to extract the volatile oil. The volatile oil is made into β-cyclodextrin inclusion compound by β-cyclodextrin inclusion. The amount of β-cyclodextrin added is equal to that of the volatile oil. The mass ratio is 5:1;

[0098] b. Herbal dregs, Asarum, Guizhi, Fangfeng, Ligusticum chuanxiong and Angelica extract volatile oil and the remaining 9 flavors add 18.6kg of water, decoct and extract for 1.5 hours, that is, one decoction; after one decoction, add 14.88kg of the medicine residue Decoction in water for 1 ho...

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Abstract

The invention discloses a preparation method of pubescent angelica and mistletoe decoction formula granules and a quality control method thereof. The preparation method includes the steps that radix angelicae pubescentis, asarum, cassia twigs, radices sileris, ligusticum wallichii and radix angelica sinensis are extracted for obtaining volatile oil, and the volatile oil is subjected to clathration of beta-cyclodextrin; water with the weight 5-15 times the weight of total feeding amount is added to herbal residues and other nine types of medicine, and decoction and extraction are conducted twice; filtrate is subjected to vacuum decompression concentration; a concentrated solution is subjected to spray drying, spray-drying powder is obtained, and the spray-drying powder is crushed into submicron powder through an airflow pulverizer; maltodextrin and a beta-cyclodextrin clathrate compound are added to the submicron powder to be mixed uniformly, granulation is conducted through a dry method, and the pubescent angelica and mistletoe decoction formula granules are obtained. The quality control method includes the steps of infrared fingerprint spectra, thin-layer qualitative identification and HPLC content measuring. By means of the method, the advantage of drug matching can be fully played, and effective ingredients are maintained to the maximum degree; a perfect quality standard is completed, a once-measurement multi-evaluation technology of thin-layer chromatography is adopted, quality control is conducted in combination with infrared spectroscopy and chromatography, and the quality of the formula granules can be effectively controlled.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Duhuojijietang formula granules and a quality control method thereof. Background technique [0002] Duhuojijietang is derived from Sun Simiao's "Essential Prescriptions for Emergency Treatment", which is included in the 2010 edition of the Chinese Pharmacopoeia. It consists of Duhuo, Mulberry, Eucommia, Achyranthes, Asarum, Gentiana, Poria, Cinnamon, Fangfeng, and Chuanxiong , Ginseng, licorice, angelica, peony, rehmannia glutinosa 15 medicine composition, has the effect of nourishing blood and relaxing muscles, expelling wind and dampness, replenishing liver and kidney, treating arthralgia for a long time, liver and kidney deficiency, deficiency of qi and blood, external invasion of wind, cold and dampness , Lumbar and knee cold pain, soreness and weakness, poor flexion and extension, or numbness and dryness, c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/16A61P29/00A61P25/02A61P27/06A61P17/00A61P19/02A61P19/08A61P15/10A61P1/16A61P1/00G01N21/35G01N30/90
CPCA61K9/1652A61K36/076A61K36/185A61K36/21A61K36/232A61K36/236A61K36/238A61K36/258A61K36/268A61K36/46A61K36/484A61K36/51A61K36/54A61K36/65A61K36/71A61K36/804A61K2236/331A61K2236/39G01N21/35G01N30/90A61K2300/00
Inventor 谭登平钟华林霍文杰杜兰哲官永河赵径华
Owner GUANGDONG YIFANG PHARMA
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