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A preparation method and quality control method of Longdan Xiegan Decoction formula granules

A technology of Longdan Xiegan Decoction and formula granules, which can be applied to medical formulas, medical preparations containing active ingredients, measuring devices, etc., can solve problems such as lack of quality standards, reduce inspection costs, increase curative effect, and avoid damage Effect

Active Publication Date: 2019-11-12
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, due to the relatively little research on compound formula granules and the lack of current quality standards in the industry, it is necessary to study a perfect quality standard to ensure the safety, effectiveness and controllable quality of the product

Method used

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  • A preparation method and quality control method of Longdan Xiegan Decoction formula granules
  • A preparation method and quality control method of Longdan Xiegan Decoction formula granules
  • A preparation method and quality control method of Longdan Xiegan Decoction formula granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] A preparation method of Longdan Xiegan Decoction formula granules, comprising the steps of:

[0066] a. Take gentian 250g, gardenia 250g, skullcap 250g, Alisma 250g, rehmannia glutinosa 250g, psyllium 250g, angelica 250g, bupleurum 250g, akeba 250g, licorice 250g, add 25kg of water, decoct for 2 hours , that is, the first decoction; after the first decoction, add 20kg of water to the dregs, and decoct for 1 hour, that is, the second decoction;

[0067] b. Combine the two decoction filtrates, filter, and concentrate the filtrate under reduced pressure under vacuum to a concentrated solution with a relative density of 1.06 at 95°C;

[0068] c. Take the above-mentioned concentrated solution for spray drying, control the inlet air temperature at 175°C-185°C, and the outlet air temperature at 85-95°C to obtain spray-dried powder, which is pulverized into superfine powder by jet mill;

[0069] d. Adding the superfine powder to 10% of the weight of the superfine powder by mal...

Embodiment 2

[0071] A preparation method of Longdan Xiegan Decoction formula granules, comprising the steps of:

[0072] a. Take gentian 300g, gardenia 300g, skullcap 300g, Alisma 300g, rehmannia glutinosa 300g, psyllium 200g, angelica 200g, bupleurum 200g, akeba 200g, licorice 200g, add 37.5kg of water, decoct for 1.5 hour, that is, the first decoction; after the first decoction, add 32.5kg of water to the dregs, and decoct for 1 hour, that is, the second decoction;

[0073]b. Combine the two decoction filtrates, filter, and concentrate the filtrate under reduced pressure under vacuum to a concentrated solution with a relative density of 1.09 at 95°C;

[0074] c. Take the above-mentioned concentrated solution for spray drying, control the inlet air temperature at 175°C-185°C, and the outlet air temperature at 85-95°C to obtain spray-dried powder, which is pulverized into superfine powder by jet mill;

[0075] d. Add the superfine powder to maltodextrin dry granulation accounting for 15% ...

Embodiment 3

[0079] A preparation method of Longdan Xiegan Decoction formula granules, comprising the steps of:

[0080] a, get Gentiana 350g, Gardenia 350g, Scutellaria baicalensis 350g, Alisma 350g, Rehmannia glutinosa 350g, Plantago 150g, Angelica 150g, Bupleurum 150g, Chuanketong 150g, licorice 150g, add 32.5kg of water, decoct for 1 hours, that is, the first decoction; after the first decoction, add 25kg of water to the dregs, and decoct for 1 hour, that is, the second decoction;

[0081] b. Combine the two decoction filtrates, filter, and concentrate the filtrate under reduced pressure under vacuum to a concentrated solution with a relative density of 1.12 at 95°C;

[0082] c. Take the above-mentioned concentrated solution for spray drying, control the inlet air temperature at 175°C-185°C, and the outlet air temperature at 85-95°C to obtain spray-dried powder, which is pulverized into superfine powder by jet mill;

[0083] d. Adding the superfine powder to maltodextrin dry granulati...

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Abstract

The invention discloses a preparation method of Gentiana scabra Bunge liver fire purging formula particles. The preparation method comprises the following steps: taking decoction pieces of Gentiana scabra Bunge, Fructus Gardeniae, Radix Scutellariae, Rhizoma Alismatis, glutinous rehmannia, Semen plantaginis, Chinese angelica root, radix bupleuri, Caulis Clematidis armandii and licorice root, adding water with the weight 5-15 times the total weight of the decoction pieces, and carrying out decocting extraction twice; mixing above obtained two decoction filtrates, and carrying out vacuum reduced pressure concentration on the obtained mixed filtrate; and carrying out spray drying the obtained concentrate to obtain spray dried powder, crushing the spray dried powder by using an airflow crusher to form ultrafine powder, adding the ultrafine powder to maltodextrin, and carrying out dry granulation to prepare the Gentiana scabra Bunge liver fire purging formula particles. A quality control method of the particles comprises infrared fingerprint, thin layer qualitative discrimination and HPLC content determination. The method fully performs advantages of traditional Chinese medicine compatibility, and maximally reserves effective components; and quality control is carried out through establishing complete quality standards, adopting a one-measurement and multiple-evaluation technology of thin layer chromatography and combining infrared spectroscopy with chromatography, so the quality of the compound particles is effectively controlled.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Longdan Xiegan Decoction formula granules and a quality control method thereof. Background technique [0002] Longdan Xiegan Decoction is composed of gentian grass, scutellaria baicalensis, gardenia, Alisma, akebia, angelica, rehmannia glutinosa, Bupleuri, raw licorice, and plantain seed. This prescription has the effect of clearing away excess fire in the liver and gallbladder, and clearing damp-heat in the liver meridian. It is traditionally used for the treatment of inflammation of the liver and gallbladder and the symptoms of damp-heat in the liver meridian. The medicinal taste of this prescription can be roughly divided into 4 parts: ①Bitter cold purging gunpowder. Gentiana is bitter and cold, returns to the liver and gallbladder meridian. Reduce heat and clear. ② medicine for expelling dampness an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/884A61P1/16G01N21/3563G01N30/90G01N30/02
CPCA61K9/1652A61K36/232A61K36/233A61K36/484A61K36/515A61K36/539A61K36/68A61K36/716A61K36/744A61K36/804A61K36/884A61K2236/331A61K2236/39A61K2236/51A61K2236/53G01N21/3563G01N30/02G01N30/90G01N2030/027A61K2300/00
Inventor 谭登平钟华林霍文杰杜兰哲官永河赵径华
Owner GUANGDONG YIFANG PHARMA
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