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A detection method for formula granules of Maxing Shigan Decoction

A technology of Maxing Shigan Decoction and formula granules, which is applied in the field of preparation of Maxing Shigan Decoction formula granules, to achieve the effect of reducing the floating of ephedra and controlling the quality

Active Publication Date: 2020-03-17
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In China, hundreds of single-flavored formula granules have been launched, but because the current Chinese medicine formula granules are all single-flavored Chinese herbal extracts, people worry about "co-decoction" and "separate decoction". difference problem

Method used

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  • A detection method for formula granules of Maxing Shigan Decoction
  • A detection method for formula granules of Maxing Shigan Decoction
  • A detection method for formula granules of Maxing Shigan Decoction

Examples

Experimental program
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Effect test

Embodiment 1

[0051] A preparation method of Maxing Shigan Decoction formula granules, comprising the steps of:

[0052] a. Take 49.9kg of water, boil it, add 1070g of ephedra, 1070g of bitter almond, 710g of roasted licorice, and then add 2140g of gypsum, decoct and extract for 1 hour, that is, decoct once; after decocting, add 44.91kg of water to the dregs of the medicine, decoct Extract for 1 hour, that is, fry for the second time;

[0053] b. Combine the two decoction filtrates, filter, and concentrate the filtrate under reduced pressure under vacuum to a concentrated solution with a relative density of 1.04 at 95°C;

[0054] c. Take the above concentrate and spray dry it. Control the air inlet temperature at 175°C-185°C and the outlet air temperature at 85-95°C to obtain a spray-dried powder. Add an appropriate amount of maltodextrin to the spray-dried powder for dry granulation to obtain a particle size of 16-40 Formula granules of Maxing Shigan Decoction with uniform color and luste...

Embodiment 2

[0058] A preparation method of Maxing Shigan Decoction formula granules, comprising the steps of:

[0059] a. Take 31.88kg of water, boil it, put in 535g of ephedra, 535g of bitter almond, 355g of roasted licorice, and then put in 700g of gypsum, decoct for extraction for 1.5 hours, that is, decoct once; after decocting, add 21.25kg of water to the dregs of the medicine, decoct Extract for 1 hour, that is, fry for the second time;

[0060] b. Combine the two decoction filtrates, filter, and concentrate the filtrate under reduced pressure under vacuum to a concentrated solution with a relative density of 1.02 at 95°C;

[0061] c. Take the above concentrate and spray dry it. Control the air inlet temperature at 175°C-185°C and the outlet air temperature at 85-95°C to obtain a spray-dried powder. Add an appropriate amount of maltodextrin to the spray-dried powder for dry granulation to obtain a particle size of 16-40 Formula granules of Maxing Shigan Decoction with uniform color...

Embodiment 3

[0065] A preparation method of Maxing Shigan Decoction formula granules, comprising the steps of:

[0066] a. Take 14.97kg of water, boil it, put in 321g of ephedra, 321g of bitter almond, 213g of roasted licorice, and then put in 642g of gypsum, decoct for extraction for 2 hours, that is, decoct once; after decocting, add 7.49kg of water to the dregs of the medicine, decoct Extract for 0.5 hours, that is, fry for the second time;

[0067] b. Combine the two decoction filtrates, filter, and concentrate the filtrate under reduced pressure under vacuum to a concentrated solution with a relative density of 1.06 at 95°C;

[0068] c. Take the above concentrate and spray dry it. Control the air inlet temperature at 175°C-185°C and the outlet air temperature at 85-95°C to obtain a spray-dried powder. Add an appropriate amount of maltodextrin to the spray-dried powder for dry granulation to obtain a particle size of 16-40 Formula granules of Maxing Shigan Decoction with uniform color...

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Abstract

The invention discloses a preparation method and a quality control method of formula granules containing ephedra, semen armeniacae amarae, gypsum and licorice root. The preparation method comprises the following steps: boiling water which is 5-15 times weight of the total amount of materials; putting ephedra, semen armeniacae amarae, and honey-fried licorice root slices; putting gypsum slices; decocting and extracting twice, mixing two decoctions, and filtering; concentrating the filtrate in vacuum at reduced pressure; drying the concentrate by spray; and granulating by a dry method. The quality control method comprises infrared fingerprint, thin-layer qualitative identification and HPLC (high performance liquid chromatography) content determination. According to the preparation method, effective ingredients in the compound can be furthest maintained, advantages of traditional Chinese medicine compatibility can be sufficiently achieved, the whole concept of traditional Chinese medicine can be reflected, a thorough quality standard of the formula granules containing ephedra, semen armeniacae amarae, gypsum and licorice root can be established, and the quality of compound granules can be effectively controlled.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Maxing Shigan Decoction formula granules and a quality control method thereof. Background technique [0002] Maxing Shigan Decoction is composed of four herbs: ephedra, almond, raw gypsum, and roasted licorice. It has the effects of venting stagnant heat, clearing the lungs and relieving asthma. This prescription comes from Zhang Zhongjing's "Treatise on Febrile Diseases", which is a variant of Mahuang Decoction. That is to use gypsum to transform Guizhi into a pungent and warm method. The syndrome of this prescription is caused by exogenous pathogenic wind, pathogenic heat closing the lungs, or wind pathogens transforming heat into the interior, and the heat is blocked in the lungs. Therefore, this prescription is based on body heat and cough and asthma, and clears and ventilates lung qi as the treatment...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90A61K36/736A61K9/16A61P11/00A61P11/06A61P11/02G01N30/36G01N21/3577A61K33/06
Inventor 谭登平程学仁杜兰哲钟华林赵径华官永河霍文杰王闽予
Owner GUANGDONG YIFANG PHARMA
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