32results about How to "To achieve the purpose of reducing toxicity and increasing efficiency" patented technology

The invention provides a peony and liquorice soup formula granule, and a preparation method and a detection method of the peony and liquorice soup formula granule. The preparation method comprises the steps of weighing peony and liquorice at a mass ratio of 1:1, adding water for decocting and extracting, merging filtrate, decompressing and condensing the filtrate to obtain a concentrated solution, drying the concentrated spray, adding water for granulating and sieving, and obtaining the peony and liquorice soup formula granule. The detection method comprises the steps of identifying the peony and liquorice soup formula granule by a thin-layer chromatography, and measuring the heavy metal content, the organo-chlorine pesticide residual amount, the fingerprint spectrum, the extract content and the paeoniflorin content of the peony and liquorice soup formula granule. The peony and liquorice soup formula granule inherits advantages of a traditional Chinese medicine single-formula granule, fully considers interaction during decocting (or other processing) of a decoction piece, and has a higher value, and the detection method allows the quality of the peony and liquorice soup formula granule to be controlled more effectively, so that the peony and liquorice soup formula granule is safer to use.

The invention discloses a preparation method of pubescent angelica and mistletoe decoction formula granules and a quality control method thereof. The preparation method includes the steps that radix angelicae pubescentis, asarum, cassia twigs, radices sileris, ligusticum wallichii and radix angelica sinensis are extracted for obtaining volatile oil, and the volatile oil is subjected to clathration of beta-cyclodextrin; water with the weight 5-15 times the weight of total feeding amount is added to herbal residues and other nine types of medicine, and decoction and extraction are conducted twice; filtrate is subjected to vacuum decompression concentration; a concentrated solution is subjected to spray drying, spray-drying powder is obtained, and the spray-drying powder is crushed into submicron powder through an airflow pulverizer; maltodextrin and a beta-cyclodextrin clathrate compound are added to the submicron powder to be mixed uniformly, granulation is conducted through a dry method, and the pubescent angelica and mistletoe decoction formula granules are obtained. The quality control method includes the steps of infrared fingerprint spectra, thin-layer qualitative identification and HPLC content measuring. By means of the method, the advantage of drug matching can be fully played, and effective ingredients are maintained to the maximum degree; a perfect quality standard is completed, a once-measurement multi-evaluation technology of thin-layer chromatography is adopted, quality control is conducted in combination with infrared spectroscopy and chromatography, and the quality of the formula granules can be effectively controlled.

The invention provides adenophora radix ophiopogonis soup formula granules as well as a preparation method and a detection method thereof. The granules comprises the raw materials as follows: radix glehniae, radix polygonati officinalis, radix ophiopogonis, radices trichosanthis, hyacinth beans, mulberry leaves and raw liquorice in the mass ratio of (0.5-2):(0.5-2):(0.5-2):(1-3):(0.5-2):(0.1-1.2):(0.1-1), and the raw materials are respectively immersed for multiple times, boiled and filtered, so as to obtain cream after filter liquors are mixed and concentrated, and the cream is dried to be prepared into granules. The detection method comprises the following steps of: identifying the adenophora ophiopogonis soup formula granules through a using thin-layer chromatography; measuring the content of organic chloride pesticide residue in the adenophora ophiopogonis soup formula granules through using a pesticide residue measuring method; measuring the content of heavy metal in the adenophora ophiopogonis soup formula granules through using a residue on ignition examination method; measuring the content of extractum of the adenophora ophiopogonis soup formula granules through using a hot dipping method; and measuring the content of substances in the adenophora ophiopogonis soup formula granules through a using high-efficiency liquid chromatography.

The invention belongs to the technical field of medicines, and specifically discloses a tripterygium wilfordii-caulis sinomenii microemulsion gel and a preparation method thereof. A prescription of the tripterygium wilfordii-caulis sinomenii microemulsion gel comprises caulis sinomenii extracts, tripterygium wilfordii extracts, a surfactant, a cosurfactant, an oil phase, a gel matrix material and water. The preparation method of the tripterygium wilfordii-caulis sinomenii microemulsion gel comprises the steps of dissolving medicines in the oil phase, mixing uniformly with the surfactant, the cosurfactant and water to obtain microemulsion; adding the gel matrix material into the microemulsion for swelling; regulating a pH value; and stirring uniformly. The tripterygium wilfordii-caulis sinomenii microemulsion gel is administered through skins, increases permeation rate through the skins, promotes transdermal absorption of the tripterygium wilfordii and caulis sinomenii, overcomes the problem of strong mobility of the microemulsion, achieves the object of sustained release and long-term efficacy, reduces toxicity of tripterygium wilfordii, and improves a curative effect of caulis sinomenii. The tripterygium wilfordii-caulis sinomenii microemulsion gel has a significant curative effect for treating rheumatoid arthritis, has small toxic or side effect, and has good product stability; and the preparation process is simple and suitable for large-scale production.

The invention discloses a preparation method of Gentiana scabra Bunge liver fire purging formula particles. The preparation method comprises the following steps: taking decoction pieces of Gentiana scabra Bunge, Fructus Gardeniae, Radix Scutellariae, Rhizoma Alismatis, glutinous rehmannia, Semen plantaginis, Chinese angelica root, radix bupleuri, Caulis Clematidis armandii and licorice root, adding water with the weight 5-15 times the total weight of the decoction pieces, and carrying out decocting extraction twice; mixing above obtained two decoction filtrates, and carrying out vacuum reduced pressure concentration on the obtained mixed filtrate; and carrying out spray drying the obtained concentrate to obtain spray dried powder, crushing the spray dried powder by using an airflow crusher to form ultrafine powder, adding the ultrafine powder to maltodextrin, and carrying out dry granulation to prepare the Gentiana scabra Bunge liver fire purging formula particles. A quality control method of the particles comprises infrared fingerprint, thin layer qualitative discrimination and HPLC content determination. The method fully performs advantages of traditional Chinese medicine compatibility, and maximally reserves effective components; and quality control is carried out through establishing complete quality standards, adopting a one-measurement and multiple-evaluation technology of thin layer chromatography and combining infrared spectroscopy with chromatography, so the quality of the compound particles is effectively controlled.

The invention provides "sanhuang" heart-fire removing decoction formula granules and a preparing method and a detection method thereof. The granules are prepared by adding water into rheum officinale, root of baikal skullcap and Chinese goldthread in a weight ratio of 2:1:1, decocting, filtering, and concentrating and drying filtrate. The detection method includes: identifying the granules by a thin-layer chromatography method; detecting a fingerprint spectrum of the granules by a high performance liquid chromatography method; detecting the extract content of the granules by a hot dipping method; and detecting the contents of compounds in the granules by a high performance liquid chromatography method. The "sanhuang" heart-fire removing decoction is prepared by mixed-decoction according to traditional methods, advantages of traditional Chinese medicine compatibility are fully exerted, the holism concept of traditional Chinese medicines is reflected, and effects of toxicity reducing and efficacy enhancing are achieved. Disadvantages brought by simple addition of medicines in a taking process of single-medicine formula granules at present are overcome. Process conditions and complete quality standards of the granules are established.

The invention relates to a preparation method of urushiol-loading pH responsive amphiphilic copolymer micelle. The preparation method comprises the following steps: firstly, dissolving a certain amount of mPEG, hydrophobic amine monomer, 5-amino-1-pentanol and 1,4-butanediol diacrylate in DMSO to prepare a reaction solution with a certain concentration, performing polyreaction for 20-48h, then adding a certain amount of 1,3-pentanediamine, and continuing the reaction for 24h to synthesize polyethylene glycol-poly-beta-amino ester amphiphilic copolymer (mPEG-PBAE); and then taking and dissolving a certain amount of mPEG-PBAE and urushiol in DMF, performing uniform ultrasonic mixing, and performing dialyzing, centrifuging and filtering to obtain the urushiol-loading pH responsive amphiphiliccopolymer micelle. The drug-loading micelle has an average particle diameter of 140-160nm, good stability, obvious pH responsive drug-release property, good biocompatibility, and good targeting anti-tumor activity, can be applied to clinical targeting anti-tumor drugs, has very high added value, and can become a new technique for clinically developing urushiol targeting anti-tumor drugs.

The invention discloses a preparation method and a quality control method of rhizoma cyperi four-material granules. The preparation method comprises the steps of extracting volatile oil from four medicinal materials including angelica, Szechuan lovage rhizome, rhizoma cyperi and costus root by adopting a steam distillation method, performing grinding inclusion on the volatile oil by adopting beta-cyclodextrin, adding prepared rehmannia root, white peony root and rhizoma corydalis into the residue obtained after the volatile oil is extracted, adding water for decocting and extracting, precipitating the extract by using 95% ethanol, standing, filtering, concentrating the supernate under reduced pressure, drying to obtain a dry extract, adding powdered sugar and dextrin, mixing uniformly, granulating, drying, shaping, adding an inclusion compound, and mixing uniformly, thus obtaining the four-material granules. The quality control method comprises thin-layer qualitative identification and HPLC (High Performance Liquid Chromatography) content measurement. The volatile oil is separately extracted and included, so that double effects of reducing the consumption of accessories and exerting the treatment effect are achieved; compared with the conventional single-formula granules, the four-material granules having various medicinal flavors can sufficiently exert the advantage of compatibility of Chinese medicaments; and a perfect quality standard is established, so that the quality of the compound granules can be effectively controlled.

The present invention relates to a preparation method of nutmeg mix-fried with wheat bran. Said preparation method includes the following steps: selecting raw material nutmeg, cleaning its, removing its worm-holed portion and tainted portion, adding proper quantity of water and soaking the cleaned nutmeg for 2-24hr, then taking out, cooling and drying to remove its surface water content, placing said dried nutmeg and wheat bran into a medicine-frying pan or a rotary medicine-frying machine whose rotating speed is 20rpm, bran-frying temperature is 130-200deg.C, mixing ratio of medicine and wheat bran is 100:40-60, and the bran-frying time is 15-35min, when its surface is brown colour, has cracks and produces intense fragrance, taking out and sieving to remove wheat bran, cooling so as to obtain the invented nutmeg mix-fried wheat bran. As compared with raw nutmeg material the chemical components and pharmacological action of said nutmeg produce obvious change, in which the effective component methyl syringophenol and methyl isozyringophenol contents are increased and the toxic component nutmeg ether and sassafras ether are reduced.

The invention provides an intestinal tract slow-release bovine colostrum and sea cucumber peptide chewable tablet and a preparation method thereof. The chewable tablet comprises the following components: casein phosphopeptide, sea cucumber peptide, bovine colostrum powder, soybean peptide, concentrated whey protein, lutein ester, vitamin C, fruit and vegetable powder, resistant dextrin, lactose, erythritol, sorbitol, DL-malic acid, xylooligosaccharide and magnesium stearate; and the chewable tablet also comprises a targeted slow-release biocompatible microcapsule which comprises a polycarbonate film, bovine serum albumin freeze-dried powder, amino acid, chitosan oligosaccharide, lecithin and poly(2-ethyl-2-oxazoline) grafted glucan nanoparticles. The intestinal tract slow-release bovine colostrum and sea cucumber peptide chewable tablet prepared by using the preparation method and the components provided by the invention can release active peptides with quality and nutrition effects inintestinal tracts, and can penetrate through a blood brain barrier to act on brain cells to repair cardiovascular and cerebrovascular diseases and injuries after oxidative stress; and the bovine colostrum powder and the concentrated whey protein are digested in the stomach in an auxiliary manner, so the human immunity is enhanced.

The invention relates to the field of new dosage forms and new technologies of medicines, in particular to a compound and application thereof, and the compound comprises two medicines, namely paclitaxel and bufalin. As the two drugs are poor in water solubility, the two drugs are respectively encapsulated in carriers of cholic acid-polyethylene glycol/vitamin E polyethylene glycol succinate to form mixed polymer micelles, and then the mixed polymer micelles are combined to treat liver cancer. The combined application of the paclitaxel micelles and the bufalin micelles improves the problems of drug resistance of paclitaxel and high toxicity of bufalin, and results of toxicity reduction and efficacy enhancement are generated.