32results about How to "To achieve the purpose of reducing toxicity and increasing efficiency" patented technology

The invention belongs to the technical field of medicines, and specifically discloses a tripterygium wilfordii-caulis sinomenii microemulsion gel and a preparation method thereof. A prescription of the tripterygium wilfordii-caulis sinomenii microemulsion gel comprises caulis sinomenii extracts, tripterygium wilfordii extracts, a surfactant, a cosurfactant, an oil phase, a gel matrix material and water. The preparation method of the tripterygium wilfordii-caulis sinomenii microemulsion gel comprises the steps of dissolving medicines in the oil phase, mixing uniformly with the surfactant, the cosurfactant and water to obtain microemulsion; adding the gel matrix material into the microemulsion for swelling; regulating a pH value; and stirring uniformly. The tripterygium wilfordii-caulis sinomenii microemulsion gel is administered through skins, increases permeation rate through the skins, promotes transdermal absorption of the tripterygium wilfordii and caulis sinomenii, overcomes the problem of strong mobility of the microemulsion, achieves the object of sustained release and long-term efficacy, reduces toxicity of tripterygium wilfordii, and improves a curative effect of caulis sinomenii. The tripterygium wilfordii-caulis sinomenii microemulsion gel has a significant curative effect for treating rheumatoid arthritis, has small toxic or side effect, and has good product stability; and the preparation process is simple and suitable for large-scale production.

The invention discloses a method for preparing siwu decoction formula granules and a quality control method thereof. The method for preparing the siwu decoction formula granules comprises steps: prepared rehmannia roots, angelica sinensis, radix paeoniae alba and ligusticum wallichii medicinal slices are added with water which is 5-15 times of the weight of total inventory, are extracted for two times, aromatic water is collected and is combined with two frying filter liquids, are decompressed and concentrated in vacuum, a concentrated solution is added with beta (Beta)-cyclodextrin and silicon dioxide to uniformly stir and obtains a clear paste, and the aromatic water and the aromatic water are sprayed and dried after being uniformly mixed, and are pelletized through a dry method to prepare the siwu decoction formula granules. The quality control method of the siwu decoction formula granules comprises qualitative identification of an infrared fingerprint spectrum and a thin layer and content determination of a high performance liquid chromatography (HPLC). The method for preparing siwu decoction formula granules and the quality control method thereof decoct in a combined mode according to a traditional method, can perfectly take full advantages of drug matching compared with an existing method that various medicinal odours are added when single formula particles are taken, reflects the overall concept of Chinese medicine, guarantees to achieve the purpose of reducing toxicity and enhancing efficacy, supplies novel selection for clinical medication, builds a perfect quality standard, controls quality by combining a power-spectral method and a chromatography, and can effectively control quality of complex granules from the overall to the more specific.

The invention provides fluid-increasing decoction formula granules. The fluid-increasing decoction formula granules contain extracts prepared by the step of decocting radix scrophulariae, radix ophiopogonis and radix rehmanniae recen. The invention also provides a preparation method, application and a detection method of the fluid-increasing decoction formula granules. According to the fluid-increasing decoction formula granules, the defect that various herbal medicines are simply added when the conventional single-component formula granules are taken is overcome, the compatibility advantages of traditional Chinese medicine are fully exerted, the holistic thinking of traditional Chinese medicine is reflected, the aim of reducing toxicity and enhancing efficacy is ensured, the fluid-increasing decoction formula granules are quasi steady and controllable in quality and convenient to store and carry by patients, and the decoction trouble is avoided. The preparation method of the fluid-increasing decoction formula granules is simple, the herbal medicines are decocted together according to the traditional method, and the characteristics of the traditional Chinese medicine are met. According to the detection method of the fluid-increasing decoction formula granules, the perfect quality standard of the fluid-increasing decoction formula granules is established, and the quality of the formula granules can be effectively controlled.

The invention provides a formula granule of Sanhuang Xiexin Decoction and its preparation method and detection method. The formula granule of Sanhuang Xiexin Decoction is decocted with rhubarb, scutellaria baicalensis and Coptis chinensis in a mass ratio of 2:1:1, and filtered. , and then concentrated and dried the filtrate; the detection method includes identifying the Sanhuang Xiexin Decoction formula granules by thin-layer chromatography; determining the fingerprint of the Sanhuang Xiexin Decoction formula granules by high performance liquid chromatography; Determination of the extract content of the Sanhuang Xiexin Decoction granules by hot soaking method; determination of the substance content in the Sanhuang Xiexin Decoction formula granules by high performance liquid chromatography. The Sanhuang Xiexin Decoction of the present invention is decocted according to the traditional method, which gives full play to the advantages of Chinese medicine compatibility, embodies the overall concept of Chinese medicine, ensures that it achieves the purpose of reducing toxicity and increasing efficiency, and overcomes the simple taste of each medicine when taking the current single-flavor formula granules. The shortcomings brought about by the addition established the technological conditions and perfect quality standards of Sanhuang Xiexin Tang formula granules.

The invention relates to a preparation and preparation method of ginseng flower. Honey, onion and ginseng flower are scientifically processed into a preparation, which retains the active ingredients of ginseng flower, enhances the effect of ginseng flower for nourishing qi, and changes the coldness of ginseng flower. Coolness, after adding refined honey, it can increase the moistness of ginseng, reconcile the medicinal properties of the present invention, improve the taste and be more conducive to human body absorption, and improve the tonic effect of ginseng. At the same dose, the purpose of reducing toxicity and increasing efficiency can be achieved. It is of great significance to protect scarce medicinal resources.

The invention discloses a compound drug composition for delivery and an application of the compound drug composition. The compound drug composition for the delivery comprises the following active ingredients: oxytocin and methylergonovine, wherein methylergonovine is present in a form of free or pharmaceutically acceptable salt. The compound drug composition for the delivery can achieve purposes of attenuation and synergism; compared with the prior art, the compound drug composition has stronger activity, takes effect more quickly and has longer duration and smaller adverse reactions; and the composition can be prepared into the drug composition drug administered to mammals including human beings, and is used for treating massive haemorrhage caused by active intervention at the third stage of labor and after the delivery.

The invention discloses a preparation method of Gentiana scabra Bunge liver fire purging formula particles. The preparation method comprises the following steps: taking decoction pieces of Gentiana scabra Bunge, Fructus Gardeniae, Radix Scutellariae, Rhizoma Alismatis, glutinous rehmannia, Semen plantaginis, Chinese angelica root, radix bupleuri, Caulis Clematidis armandii and licorice root, adding water with the weight 5-15 times the total weight of the decoction pieces, and carrying out decocting extraction twice; mixing above obtained two decoction filtrates, and carrying out vacuum reduced pressure concentration on the obtained mixed filtrate; and carrying out spray drying the obtained concentrate to obtain spray dried powder, crushing the spray dried powder by using an airflow crusher to form ultrafine powder, adding the ultrafine powder to maltodextrin, and carrying out dry granulation to prepare the Gentiana scabra Bunge liver fire purging formula particles. A quality control method of the particles comprises infrared fingerprint, thin layer qualitative discrimination and HPLC content determination. The method fully performs advantages of traditional Chinese medicine compatibility, and maximally reserves effective components; and quality control is carried out through establishing complete quality standards, adopting a one-measurement and multiple-evaluation technology of thin layer chromatography and combining infrared spectroscopy with chromatography, so the quality of the compound particles is effectively controlled.

The invention discloses a preparation method and a quality control method of rhizoma cyperi four-material granules. The preparation method comprises the steps of extracting volatile oil from four medicinal materials including angelica, Szechuan lovage rhizome, rhizoma cyperi and costus root by adopting a steam distillation method, performing grinding inclusion on the volatile oil by adopting beta-cyclodextrin, adding prepared rehmannia root, white peony root and rhizoma corydalis into the residue obtained after the volatile oil is extracted, adding water for decocting and extracting, precipitating the extract by using 95% ethanol, standing, filtering, concentrating the supernate under reduced pressure, drying to obtain a dry extract, adding powdered sugar and dextrin, mixing uniformly, granulating, drying, shaping, adding an inclusion compound, and mixing uniformly, thus obtaining the four-material granules. The quality control method comprises thin-layer qualitative identification and HPLC (High Performance Liquid Chromatography) content measurement. The volatile oil is separately extracted and included, so that double effects of reducing the consumption of accessories and exerting the treatment effect are achieved; compared with the conventional single-formula granules, the four-material granules having various medicinal flavors can sufficiently exert the advantage of compatibility of Chinese medicaments; and a perfect quality standard is established, so that the quality of the compound granules can be effectively controlled.

The invention discloses a detoxification processing technology of aconitum sinomontanum nakai. The detoxification processing technology comprises the steps: washing and selecting aconitum sinomontanum nakai medicinal materials; softening; chopping into sections; drying in the shade to obtain crude decoction pieces; uniformly stirring by using licorice juices; steaming for 3-5 hours at the temperature of 115-127 DEG C under the pressure of 0.10-0.15 MPa; taking out and drying to obtain the aconitum sinomontanum nakai. An experiment proves that the processed aconitum sinomontanum nakai has 4.98-7.75 percent of the content of total alkaloids and 1.17-1.48 percent of the content of lappaconitine. Relative to the aconitum sinomontanum nakai medicinal material, the content of the total alkaloids is increased by 130.65-141.75 percent, and the content of the lappaconitine is reduced by 46.62-55.56 percent; because the total alkaloids of the aconitum sinomontanum nakai is greatly increased, the content of the lappaconitine in the aconitum sinomontanum nakai medicinal materials is greatly reduced while the pharmacological effect is maintained; therefore, the toxicity is greatly reduced, the aim of reducing toxicity and increasing efficiency is truly fulfilled, and the safety and the efficiency of clinical medication are guaranteed.

The invention discloses a preparation method of pubescent angelica and mistletoe decoction formula granules and a quality control method thereof. The preparation method includes the steps that radix angelicae pubescentis, asarum, cassia twigs, radices sileris, ligusticum wallichii and radix angelica sinensis are extracted for obtaining volatile oil, and the volatile oil is subjected to clathration of beta-cyclodextrin; water with the weight 5-15 times the weight of total feeding amount is added to herbal residues and other nine types of medicine, and decoction and extraction are conducted twice; filtrate is subjected to vacuum decompression concentration; a concentrated solution is subjected to spray drying, spray-drying powder is obtained, and the spray-drying powder is crushed into submicron powder through an airflow pulverizer; maltodextrin and a beta-cyclodextrin clathrate compound are added to the submicron powder to be mixed uniformly, granulation is conducted through a dry method, and the pubescent angelica and mistletoe decoction formula granules are obtained. The quality control method includes the steps of infrared fingerprint spectra, thin-layer qualitative identification and HPLC content measuring. By means of the method, the advantage of drug matching can be fully played, and effective ingredients are maintained to the maximum degree; a perfect quality standard is completed, a once-measurement multi-evaluation technology of thin-layer chromatography is adopted, quality control is conducted in combination with infrared spectroscopy and chromatography, and the quality of the formula granules can be effectively controlled.