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A kind of double rattan microemulsion gel and preparation method thereof

A technology of microemulsion gel and gel matrix, which is applied in the field of medicine, can solve the problems of large side effects, strong toxicity, and low utilization, and achieve the effects of quick onset of action, reduced toxicity, and reduced dosage

Active Publication Date: 2018-08-28
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to overcome the technical defects and deficiencies such as large side effects, strong toxicity, and low utilization degree existing in the existing tripterygium wilfordii and Qingfengteng pharmaceutical oral preparations, and to provide a drug with good effect, small dosage, and no obvious toxic and side effects. Tripterygium wilfordii extract and Qingfengteng extract microemulsion gel, while the microemulsion gel solves the above problems, also realizes the combination ratio of Tripterygium wilfordii and Qingfengteng, and achieves the purpose of synergistic effect. Rheumatoid arthritis treatment offers an ideal drug

Method used

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  • A kind of double rattan microemulsion gel and preparation method thereof
  • A kind of double rattan microemulsion gel and preparation method thereof
  • A kind of double rattan microemulsion gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 Double rattan microemulsion gel formula research

[0053] 1. The method of drawing the pseudo-ternary phase diagram of microemulsion is as follows:

[0054] S1. The surfactant (AEO-9 / OP emulsifier 8:2) and co-surfactant (absolute ethanol) according to the Km value (the ratio of surfactant to co-surfactant) is 3:1, 3: 2. Mix 2:1, 1:1, 1:2, 2:3, and 1:3 separately, and mix evenly on a magnetic stirrer;

[0055] S2. According to the ratio of 9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8, 1:9, add to the mixture (Smix) obtained in S1 Oil phase (oleic acid), mix well;

[0056] S3. Place on a magnetic stirrer to adjust the temperature and rotating speed, add the water phase to the mixture drop by drop; observe the critical point when the mixed solution changes from clear to turbid, and from turbid to clear, and record the critical addition amount.

[0057] S4. Use Origin7.0 software to draw a pseudo-ternary phase diagram, and determine the proportion of each phase co...

Embodiment 2

[0147] Example 2 Preparation method of Shuangteng microemulsion gel

[0148] At room temperature, take 1.5g of the extracts of C. chinensis and Tripterygium wilfordii (ratio 1:1), add them to 1.58g of oleic acid for ultrasonic dissolution, add 7.58g of AEO-9, 1.89g of OP emulsifier, 4.73g of absolute ethanol, Stir ultrasonically evenly, add 80.72g of water drop by drop under the action of a magnetic stirrer to obtain Shuangteng microemulsion; add 2g Cp-940 to Shuangteng microemulsion, swell for 24 hours, adjust pH to 6~7, and stir evenly to obtain Shuangteng microemulsion. Rattan Microemulsion Gel.

[0149] The obtained Shuangteng microemulsion gel is composed of the following components in mass ratio: S. chinensis extract and Tripterygium twig extract 1.5%, oleic acid 1.58%, AEO-9 7.58%, OP emulsifier 1.89%, anhydrous 4.73% ethanol, 2% Cp-940, and the balance is water; the extract of C. chinensis: Tripterygium wilfordii extract=1:1.

Embodiment 3

[0150] The preparation method of embodiment 3 double rattan microemulsion gel

[0151] At room temperature, take 1 g of the extracts of Teng Teng Teng and Tripterygium wilfordii (ratio 1:1), add them to 1.47 g of oleic acid for ultrasonic dissolution, add 7.63 g of AEO-9, 1.72 g of OP emulsifier, and 5.23 g of absolute ethanol, and ultrasonically Stir evenly, add 80.95g of water drop by drop under the action of magnetic stirring to obtain Shuangteng microemulsion; add 2g Cp-940 to Shuangteng microemulsion, swell for 24 hours, adjust pH to 6~7, and stir evenly to obtain Shuangteng microemulsion glue.

[0152] The obtained Shuangteng microemulsion gel is composed of the following components in mass ratio: S. chinensis extract and Tripterygium twig extract 1%, oleic acid 1.47%, AEO-9 7.63%, OP emulsifier 1.72%, anhydrous 5.23% ethanol, 2% Cp-940, and the balance is water; the extract of C. chinensis: Tripterygium wilfordii extract=1:1.

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Abstract

The invention belongs to the technical field of medicines, and specifically discloses a tripterygium wilfordii-caulis sinomenii microemulsion gel and a preparation method thereof. A prescription of the tripterygium wilfordii-caulis sinomenii microemulsion gel comprises caulis sinomenii extracts, tripterygium wilfordii extracts, a surfactant, a cosurfactant, an oil phase, a gel matrix material and water. The preparation method of the tripterygium wilfordii-caulis sinomenii microemulsion gel comprises the steps of dissolving medicines in the oil phase, mixing uniformly with the surfactant, the cosurfactant and water to obtain microemulsion; adding the gel matrix material into the microemulsion for swelling; regulating a pH value; and stirring uniformly. The tripterygium wilfordii-caulis sinomenii microemulsion gel is administered through skins, increases permeation rate through the skins, promotes transdermal absorption of the tripterygium wilfordii and caulis sinomenii, overcomes the problem of strong mobility of the microemulsion, achieves the object of sustained release and long-term efficacy, reduces toxicity of tripterygium wilfordii, and improves a curative effect of caulis sinomenii. The tripterygium wilfordii-caulis sinomenii microemulsion gel has a significant curative effect for treating rheumatoid arthritis, has small toxic or side effect, and has good product stability; and the preparation process is simple and suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to a double rattan microemulsion gel and a preparation method thereof. Background technique [0002] Rheumatoid arthritis (RA) is a common acute or chronic inflammation of connective tissue that can recur and involve the heart. It is clinically characterized by soreness, heaviness, and pain in joints and muscles. At present, the etiology of rheumatoid arthritis has not been fully understood, and there is still no ideal treatment method and drug. In recent years, domestic research on the development of traditional Chinese medicine has shown that the use of traditional Chinese medicine to achieve the purpose of treating RA has a good prospect. [0003] Tripterygium ( Tripterygium wilfordii Hook. f.) is Euonymus, Tripterygium genus. The Tripterygium wilfordii mentioned in medicinal use mainly refers to the root of Tripterygium wilfordii, which has a remarkable eff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/59A61P19/02A61P29/00A61K36/37
CPCA61K9/06A61K36/37A61K36/59A61K2300/00
Inventor 王利胜尚红鹰巴文强王玎吕耿彬
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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