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A detoxification process of aconite

A processing technology and aconitum chinensis technology, which is applied in the field of detoxification processing technology of aconitum chinensis, and can solve the problems of limited scope of use and high toxicity of aconitum chinensis.

Active Publication Date: 2017-07-18
GANSU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a detoxification process for high aconitum to reduce the toxicity of high aconitum and preserve the efficacy of the medicine, so as to ensure the safety of clinical application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] (1) Preparation of licorice juice: cleanly select, infiltrate, slice, decoct the rhizome and roots of licorice, add water for 2 to 3 times, each time for 30 minutes, filter and combine the decoction to obtain a yellow-brown liquid; per 100kg Glycyrrhiza licorice, 300kg of licorice juice;

[0013] (2) Processing of high aconitum: Weigh 150 g of high aconitum medicinal material, wash it with water, soften it with moistening method, cut it into pieces (about 5mm), dry in the shade, then add 15ml licorice juice, mix well , stuffy, after the licorice juice is completely absorbed, put it in a vertical pressure steam sterilizer, steam it at 115°C and 0.15MPa for 5h, take it out, and dry it to obtain Gaoaconitum.

[0014] The total alkaloid content of Aconitum is 7.78%, and the content of Aconitine is 0.601%.

Embodiment 2

[0016] (1) Preparation of licorice juice: same as Example 1;

[0017] (2) Processing of high aconitum: Weigh 150 g of high aconitum medicinal material, wash it with water, soften it with moistening method, cut it into pieces (about 5mm), dry it in the shade, then add 8ml licorice juice, mix well , stuffy, after the licorice juice is completely absorbed, put it in a vertical pressure steam sterilizer, steam it at 122°C and 0.12MPa for 4 hours, take it out, and dry it to obtain Gaoaconitum.

[0018] The total alkaloid content of Gaoaconitum is 7.76%; the content of Gaoaconitine is 0.599%.

Embodiment 3

[0020] (1) Preparation of licorice juice: same as Example 1;

[0021] (2) Processing of high aconitum: Weigh 150 g of high aconitum medicinal material, wash it with water, soften it with moistening method, chop it into pieces (about 5mm), dry in the shade, then add 40ml licorice juice, mix well , stuffy, after the licorice juice is completely absorbed, put it in a vertical pressure steam sterilizer, steam it at 127°C and 0.10MPa for 3 hours, take it out, and dry it to obtain Gaoaconitum.

[0022] The total alkaloid content of Gaoaconitum is 7.71%; the content of Gaoaconitine is 0.589%.

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Abstract

The invention discloses a detoxification processing technology of aconitum sinomontanum nakai. The detoxification processing technology comprises the steps: washing and selecting aconitum sinomontanum nakai medicinal materials; softening; chopping into sections; drying in the shade to obtain crude decoction pieces; uniformly stirring by using licorice juices; steaming for 3-5 hours at the temperature of 115-127 DEG C under the pressure of 0.10-0.15 MPa; taking out and drying to obtain the aconitum sinomontanum nakai. An experiment proves that the processed aconitum sinomontanum nakai has 4.98-7.75 percent of the content of total alkaloids and 1.17-1.48 percent of the content of lappaconitine. Relative to the aconitum sinomontanum nakai medicinal material, the content of the total alkaloids is increased by 130.65-141.75 percent, and the content of the lappaconitine is reduced by 46.62-55.56 percent; because the total alkaloids of the aconitum sinomontanum nakai is greatly increased, the content of the lappaconitine in the aconitum sinomontanum nakai medicinal materials is greatly reduced while the pharmacological effect is maintained; therefore, the toxicity is greatly reduced, the aim of reducing toxicity and increasing efficiency is truly fulfilled, and the safety and the efficiency of clinical medication are guaranteed.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine processing, in particular to the detoxification processing technology of aconitum aconitum. Background technique [0002] Gaoaconitum, Ranunculaceae Aconitum Aconitum sinomontanum The root of Nakai, also known as linen seven, pocket seven, braid seven, coir raincoat seven, is one of the rare and precious "seven medicines" in Gansu, Sichuan, Taibai area of ​​Shaanxi, Shennongjia area of ​​Hubei, Yunnan, Guizhou and other places. , regulating qi and relieving pain, promoting blood circulation and removing blood stasis, it is used to treat bruises, strains, bone injuries, rheumatism pain, joint pain, numbness of limbs, insecticide and other therapeutic effects. However, the raw product of Gaoconitum is highly toxic. Many medical works have recorded that "Gaoconitou is pungent, bitter, warm, and poisonous", such as it is now recorded in "Standards of Chinese Medicinal Materials in Gansu Pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/714
CPCA61K36/714A61K2236/13A61K2236/15A61K2236/17A61K2236/31
Inventor 李芸苗小楼刘峰林吴平安李越峰
Owner GANSU UNIV OF CHINESE MEDICINE
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