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Adenophora radix ophiopogonis soup formula granules as well as preparation method and detection method thereof

A technology of Shashen Maidong Decoction and formula granules, which can be applied to medical formulas, medical preparations containing active ingredients, measuring devices, etc., can solve the problems of unfavorable process control drug monitoring, no detection methods, etc., to ensure clinical efficacy and safety, quality is accurate and controllable, and the effect of simple preparation

Active Publication Date: 2013-08-07
KANGMEI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there is no detection method for the formula granules of Shashen Maidong Decoction, which is not conducive to the control of the production process and the monitoring of drugs.

Method used

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  • Adenophora radix ophiopogonis soup formula granules as well as preparation method and detection method thereof
  • Adenophora radix ophiopogonis soup formula granules as well as preparation method and detection method thereof
  • Adenophora radix ophiopogonis soup formula granules as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] The preparation condition selection of the formula granule of embodiment 1 Radix Radix Radix Radix Radix Ginseng and Radix Ophiopogonis Decoction

[0075] 1 Materials and Instruments

[0076] 1.1 Source of medicinal materials

[0077] The decoction pieces of the medicinal materials are in accordance with the 2010 edition of the "Chinese Pharmacopoeia", provided by Kangmei Pharmaceutical Co., Ltd., and the source and place of origin are shown in Table 1.

[0078] Table 1 Source of medicinal materials

[0079]

[0080] 1.2 Instruments and equipment

[0081] B-290 Spray Dryer, Swiss Buchi Company;

[0082] RE-5205 rotary evaporator, Shanghai Yarong Biochemical Instrument Factory.

[0083] 2. The research on the extraction process of the formula granules of Shashen Maidong Decoction is as follows:

[0084] Influencing factors include: extraction times, extraction time, and water addition (both expressed in multiples of the medicinal material mass). Orthogonal te...

Embodiment 2

[0096] The preparation of the formula granule of embodiment 2 Radix Radix Radix Radix Radix Radix Ginseng and Radix Ophiopogonis Decoction

[0097] According to the proportion of the prescription, weigh 50g of Radix Ginseng, 50g of Polygonatum Polygonatum, 50g of Ophiopogon japonicus, 75g of trichosanthum pollen, 50g of lentils, 30g of mulberry leaves, 15g of raw licorice, soak in water for 1 hour, decoct twice, add 8 times the amount of water for the first time and decoct for 2 hour, add 6 times the amount of water for the second time and decoct for 1 hour, filter, combine the filtrates, concentrate under reduced pressure at 80°C, concentrate to a clear paste with a relative density of 1.14 (60°C), spray dry, and the air inlet temperature is 154°C. The outlet air temperature is 95°C, the pump speed is 25%, and dried to obtain dry extract powder. Repeat six times in the same way, the obtained dry extract powder results are shown in Table 6

[0098] Table 6 dry extract yield...

Embodiment 3

[0102] The preparation of the formula granule of embodiment 3 Radix Radix Radix Radix Rhizoma Radix Radix Radix Radix L.

[0103] According to the proportion of the prescription, weigh 50g of Radix Ginseng, 50g of Polygonatum Polygonatum, 50g of Ophiopogon japonicus, 75g of trichosanthum pollen, 50g of lentils, 30g of mulberry leaves, 15g of raw licorice, soak in water for 1 hour, decoct twice, add 8 times the amount of water for the first time and decoct for 2 hour, add 6 times the amount of water for the second time and decoct for 1 hour, filter, combine the filtrate, concentrate under reduced pressure at 80°C, concentrate to a clear paste with a relative density of 1.08-1.18 (60°C), spray dry, and the air inlet temperature is 154 ℃, the air outlet temperature is 95 ℃, the pump speed is 25%, and the dry extract powder is dried, and the extract powder is granulated to obtain the obtained product.

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Abstract

The invention provides adenophora radix ophiopogonis soup formula granules as well as a preparation method and a detection method thereof. The granules comprises the raw materials as follows: radix glehniae, radix polygonati officinalis, radix ophiopogonis, radices trichosanthis, hyacinth beans, mulberry leaves and raw liquorice in the mass ratio of (0.5-2):(0.5-2):(0.5-2):(1-3):(0.5-2):(0.1-1.2):(0.1-1), and the raw materials are respectively immersed for multiple times, boiled and filtered, so as to obtain cream after filter liquors are mixed and concentrated, and the cream is dried to be prepared into granules. The detection method comprises the following steps of: identifying the adenophora ophiopogonis soup formula granules through a using thin-layer chromatography; measuring the content of organic chloride pesticide residue in the adenophora ophiopogonis soup formula granules through using a pesticide residue measuring method; measuring the content of heavy metal in the adenophora ophiopogonis soup formula granules through using a residue on ignition examination method; measuring the content of extractum of the adenophora ophiopogonis soup formula granules through using a hot dipping method; and measuring the content of substances in the adenophora ophiopogonis soup formula granules through a using high-efficiency liquid chromatography.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a traditional Chinese medicine and a preparation method and a detection method thereof, in particular to a formula granule of Shashen Maidong Decoction and a preparation method and a detection method thereof. Background technique [0002] Shashen Maidong Decoction comes from the "Regulations on Febrile Diseases". According to ancient books, this prescription is an agent for clearing away heat and promoting body fluid. In the prescription, Radix Ginseng is mainly used to nourish the yin of the lung and stomach. It is supplemented with Radix Ophiopogon japonicus and Trichosanthes Fenensis to clear away the heat in the lung and stomach. Polygonatum is used to invigorate deficiency, and lentils are used as a concurrent medicine. Finally, the bitterness of mulberry leaves is used to relieve lung heat, and the sweetness of licorice is used to produce body fluid. Body fluid i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/16A61P11/00G01N30/88G01N30/90
Inventor 曹旻旻向飞军许冬瑾马兴田汪涛孙亮
Owner KANGMEI PHARMA
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