Zengyetang formula granules and its preparation method, application and detection method
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A technology of formula particles and detection methods, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, measuring devices, etc., can solve the problems of changes in clinical efficacy, changes in pharmacological effects, and neglect of the integrity of traditional Chinese medicine decoctions.
Active Publication Date: 2016-01-20
KANGMEI PHARMA +1
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These effects include producing a solubilizing effect, changing the solubility characteristics of the solvent, changing the pH value of the solution, changing the ionization degree of the weak electrolyte of the substance, generating new components with high solubility, generating new components with low solubility, precipitation, forming complexes, inorganic ions Combining with traditional Chinese medicine ingredients to form water-insoluble salts, new compounds, and various joint effects, etc., resulting in the mixing and dissolving of single-flavor formula granules without all the active ingredients of "co-decoction of group medicines", or according to the current situation. The formula granules prepared by the process will not completely contain the active ingredients required by traditional Chinese medicine, resulting in changes in the material basis of traditional prescriptions, so that the existing formula granules cannot be equivalent to traditional Chinese medicine decoctions
[0008] Due to the neglect of the important link of "co-decoction" of group medicines and the integrity of traditional Chinese medicine decoctions, it may eventually lead to changes in clinical efficacy or pharmacological effects
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Embodiment 1
[0085] The preparation of embodiment 1 Zengyetang formula granules
[0086] Take 149.9g of Radix Scrophulariae, 120.1g of Ophiopogon japonicus, and 119.9g of Rehmannia glutinosa, soak in water for 0.5h, decoct twice for 2 hours each time, filter the decoction, combine the two filtrates, and concentrate to a relative density of 1.05-1.10 (60°C) clear paste; take clear paste, spray dry (spray drying parameters are air inlet temperature 154°C, air outlet temperature 95°C, pump speed 25%) to obtain dry extract powder, add appropriate amount of water, granulate , sieving, subpackaging, and testing to obtain 210 g of Zengyetang formula granules. Process flow chart see figure 1 .
[0087] The results of dry extract powder are shown in Table 2.
[0095] The preparation of embodiment 2 Zengyetang formula granules
[0096] Take 720g of Radix Scrophulariae, 576g of Ophiopogon japonicus, and 576g of Rehmannia glutinosa, soak in water for 0.25h, decoct twice for 1.5 hours each time, filter the decoction, combine the two filtrates, and concentrate to a relative density of 1.05-1.10 (60°C ) clear paste, spray-dried to obtain powder, add appropriate amount of water, granulate and sieve to obtain Zengyetang formula granules 1000g.
Embodiment 3
[0097] The preparation of embodiment 3 Zengyetang formula granules
[0098] Take 720g of Radix Scrophulariae, 576g of Ophiopogon japonicus, and 576g of Rehmannia glutinosa, soak in water for 1 hour, decoct twice for 2.5 hours each time, filter the decoction, combine the two filtrates, and concentrate to a relative density of 1.05-1.10 (60°C) The clear paste was spray-dried to obtain a powder, which was added with an appropriate amount of water, granulated and sieved to obtain 1010 g of Zengyetang formula granules.
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Abstract
The invention provides fluid-increasing decoction formula granules. The fluid-increasing decoction formula granules contain extracts prepared by the step of decocting radix scrophulariae, radix ophiopogonis and radix rehmanniae recen. The invention also provides a preparation method, application and a detection method of the fluid-increasing decoction formula granules. According to the fluid-increasing decoction formula granules, the defect that various herbal medicines are simply added when the conventional single-component formula granules are taken is overcome, the compatibility advantages of traditional Chinese medicine are fully exerted, the holistic thinking of traditional Chinese medicine is reflected, the aim of reducing toxicity and enhancing efficacy is ensured, the fluid-increasing decoction formula granules are quasi steady and controllable in quality and convenient to store and carry by patients, and the decoction trouble is avoided. The preparation method of the fluid-increasing decoction formula granules is simple, the herbal medicines are decocted together according to the traditional method, and the characteristics of the traditional Chinese medicine are met. According to the detection method of the fluid-increasing decoction formula granules, the perfect quality standard of the fluid-increasing decoction formula granules is established, and the quality of the formula granules can be effectively controlled.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicine. It specifically relates to a Zengyetang formula granule and a preparation method thereof, and the invention also relates to the use and detection method of the Zengyetang formula granule. Background technique [0002] Zengye Decoction was first recorded in "Tiaodian of Febrile Diseases", the original text is: Yangming febrile disease, no upper jiao syndrome, no bowel movement for several days, at present, if the person's yin element is deficient, Chengqi Decoction cannot be used, Zengye Soup master. The full prescription of Zengye Decoction has less medicinal taste and a large dosage, and the monosodium glutamate is more powerful than Lihong. It is composed of three herbs: Scrophulariae Scrophulariae, Ophiopogon japonicus and Shengdi. In the prescription, Scrophulariaceae is used as the king, nourishing yin and promoting body fluid, and invigorating kidney water to nourish intestinal...
Claims
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