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Preparation method of pubescent angelica and mistletoe decoction formula granules and quality control method thereof

A technology of Duhuo Jisheng Decoction and formula granules, which can be applied to medical formulas, medical preparations containing active ingredients, measuring devices, etc., and can solve problems such as lack of quality standards

Active Publication Date: 2016-04-13
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, due to the relatively little research on compound formula granules and the lack of current quality standards in the industry, it is necessary to study a perfect quality standard to ensure the safety, effectiveness and controllable quality of the product

Method used

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  • Preparation method of pubescent angelica and mistletoe decoction formula granules and quality control method thereof
  • Preparation method of pubescent angelica and mistletoe decoction formula granules and quality control method thereof
  • Preparation method of pubescent angelica and mistletoe decoction formula granules and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] A preparation method of Duhuo Jisheng Decoction formula granules, comprising the steps of:

[0081] a. Take 60g of Duhuo, 40g of Sangjisheng, 40g of Eucommia, 40g of Achyranthes bidentata, 40g of Asarum, 40g of Gentiana, 40g of Poria cocos, 160g of cinnamon, 200g of Fangfeng, 200g of Chuanxiong, 200g of ginseng, 200g of licorice, 200g of angelica, 200g of white peony, and Rehmannia glutinosa 200g, distill and extract volatile oil from lovage, Asarum, Guizhi, Fangfeng, Chuanxiong and Angelica. The mass ratio is 6:1;

[0082] b. Add 18.6kg of water to the dregs of Duhuo, Asarum, Guizhi, Fangfeng, Chuanxiong and Angelica after extracting volatile oil, and add 18.6kg of water to the remaining 9 flavors, decoct for 1.5 hours, that is, decoct once; after decocting, add 14.88kg of dregs water, decocting and extracting for 1 hour, that is, the second decoction;

[0083] c. Merge the two decocted filtrates, filter, and concentrate the filtrate under vacuum to a concentrated so...

Embodiment 2

[0087] A preparation method of Duhuo Jisheng Decoction formula granules, comprising the steps of:

[0088] a. Take Duhuo 200g, Sangjisheng 180g, Eucommia 180g, Achyranthes bidentata 180g, Asarum 180g, Gentiana 180g, Poria 120g, Cinnamon 80g, Fangfeng 80g, Chuanxiong 80g, Ginseng 80g, Licorice 80g, Angelica 80g, Baishao 80g, Rehmannia glutinosa 80g, distill and extract the volatile oil from lovage, Asarum, Guizhi, Fangfeng, Chuanxiong and Angelica. The mass ratio is 4:1;

[0089] b. Add 18.6kg of water to the dregs of Duhuo, Asarum, Guizhi, Fangfeng, Chuanxiong and Angelica after extracting volatile oil, and add 18.6kg of water to the remaining 9 flavors, decoct for 1.5 hours, that is, decoct once; after decocting, add 14.88kg of dregs water, decocting and extracting for 1 hour, that is, the second decoction;

[0090] c. Merge the two decocted filtrates, filter, and concentrate the filtrate to a concentrated solution with a relative density of 1.08 to 1.10 (80° C.);

[0091]...

Embodiment 3

[0096] A preparation method of Duhuo Jisheng Decoction formula granules, comprising the steps of:

[0097] a. Take 220g of Duhuo, 200g of Sangjisheng, 200g of Eucommia, 200g of Achyranthes bidentata, 200g of Asarum, 200g of Gentiana, 120g of Poria cocos, 100g of cinnamon, 60g of Fangfeng, 60g of Chuanxiong, 60g of ginseng, 60g of licorice, 60g of angelica, 60g of white peony, and rehmannia glutinosa 60g, distill and extract the volatile oil from lovage, Asarum, Guizhi, Fangfeng, Chuanxiong and Angelica. The mass ratio is 5:1;

[0098] b. Add 18.6kg of water to the dregs of Duhuo, Asarum, Guizhi, Fangfeng, Chuanxiong and Angelica after extracting volatile oil, and add 18.6kg of water to the remaining 9 flavors, decoct for 1.5 hours, that is, decoct once; after decocting, add 14.88kg of dregs water, decocting and extracting for 1 hour, that is, the second decoction;

[0099] c. Merge the two decocted filtrates, filter, and concentrate the filtrate to a concentrated solution wi...

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Abstract

The invention discloses a preparation method of pubescent angelica and mistletoe decoction formula granules and a quality control method thereof. The preparation method includes the steps that radix angelicae pubescentis, asarum, cassia twigs, radices sileris, ligusticum wallichii and radix angelica sinensis are extracted for obtaining volatile oil, and the volatile oil is subjected to clathration of beta-cyclodextrin; water with the weight 5-15 times the weight of total feeding amount is added to herbal residues and other nine types of medicine, and decoction and extraction are conducted twice; filtrate is subjected to vacuum decompression concentration; a concentrated solution is subjected to spray drying, spray-drying powder is obtained, and the spray-drying powder is crushed into submicron powder through an airflow pulverizer; maltodextrin and a beta-cyclodextrin clathrate compound are added to the submicron powder to be mixed uniformly, granulation is conducted through a dry method, and the pubescent angelica and mistletoe decoction formula granules are obtained. The quality control method includes the steps of infrared fingerprint spectra, thin-layer qualitative identification and HPLC content measuring. By means of the method, the advantage of drug matching can be fully played, and effective ingredients are maintained to the maximum degree; a perfect quality standard is completed, a once-measurement multi-evaluation technology of thin-layer chromatography is adopted, quality control is conducted in combination with infrared spectroscopy and chromatography, and the quality of the formula granules can be effectively controlled.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Duhuo Jisheng Decoction formula granules and a quality control method thereof. Background technique [0002] Duhuo Jisheng Decoction comes from Sun Simiao's "Emergency Prescriptions", which is a variety recorded in the 2010 edition of "Chinese Pharmacopoeia". , ginseng, licorice, angelica, peony, and rehmannia root, composed of 15 herbs, have the effects of nourishing blood and relaxing tendons, expelling wind and dampness, and nourishing liver and kidney. , cold pain in the waist and knees, soreness and weakness, poor flexion and extension, or numbness and dryness, and cold numbness that does not heal after a long time. In the prescription, Duhuo dispels wind and dampness, dispels cold and unblocks numbness, and is good at descending. It is good at dispelling wind-cold and damp pathogens in the lower Jiao...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K9/16A61P29/00A61P25/02A61P27/06A61P17/00A61P19/02A61P19/08A61P15/10A61P1/16A61P1/00G01N21/35G01N30/90
CPCA61K9/1652A61K36/076A61K36/185A61K36/21A61K36/232A61K36/236A61K36/238A61K36/258A61K36/268A61K36/46A61K36/484A61K36/51A61K36/54A61K36/65A61K36/71A61K36/804A61K2236/331A61K2236/39G01N21/35G01N30/90A61K2300/00
Inventor 谭登平钟华林霍文杰杜兰哲官永河赵径华
Owner GUANGDONG YIFANG PHARMA
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