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Application of pharmaceutical composition in preparation of drugs for treating cancers

A technology of composition and medicine, which is applied in the application field of pharmaceutical composition in the preparation of drugs for treating cancer, to achieve the effects of inhibiting tumor cell growth, reducing the formation of clones, and having low toxic and side effects

Active Publication Date: 2020-08-18
杜晶晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And there is currently no report on the combination of 5-fluorouracil and Shuganning preparations for the treatment of tumors

Method used

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  • Application of pharmaceutical composition in preparation of drugs for treating cancers
  • Application of pharmaceutical composition in preparation of drugs for treating cancers
  • Application of pharmaceutical composition in preparation of drugs for treating cancers

Examples

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example 1

[0051] Shuganning preparations were purchased from Ruihe Pharmaceutical Co., Ltd. Shuganning injection (20190420), 5-fluorouracil (Sigma, F6627).

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Abstract

The invention discloses a new application of a pharmaceutical composition, and concretely relates to an application of the pharmaceutical composition in the preparation of cancer treatment medicines,and the pharmaceutical composition comprises a Shuganning preparation. The pharmaceutical preparation can effectively inhibit the growth of multiple cancer cells, reduce the formation of clone numberof cancer cells, induce cancer cell death, block the cancer cell period in the S phase, effectively inhibit the growth of transplanted tumor of nude mice, does not influence the weight of nude mice, can effectively treat cancer, and has low toxic and side effects. The Shuganning preparation in the traditional Chinese medicine composition can selectively kill cancer cells, does not influence the growth of normal cells, and has a synergistic anti-tumor effect (wherein synergistic index, CI is less than 1) when being combined with 5-fluorouracil for use.

Description

technical field [0001] The invention relates to the application of a pharmaceutical composition in the preparation of medicines for treating cancer. The pharmaceutical composition is composed of Shuganning preparation and 5-fluorouracil. It also relates to the application of the Shuganning preparation in the pharmaceutical composition in the preparation of medicines for treating cancer. Background technique [0002] Cancer is one of the most harmful diseases to human life and health, and a large number of people die of cancer every year. The research and development of anticancer drugs has always been a hot spot in pharmaceutical research. Chemotherapeutic drugs commonly used in clinical practice have severe side effects, seriously affecting the health and quality of life of patients. The cost of targeted chemotherapy drugs is high, and long-term use is unaffordable for patients. Especially for triple-negative breast cancer (ER-negative, PR-negative, HER2 / neu not overexpr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61P35/00A61K31/7048A61K31/513
CPCA61K36/282A61K36/744A61K31/7048A61K36/195A61K36/315A61K36/074A61K31/513A61P35/00A61K2300/00Y02A50/30
Inventor 马文哲杜晶晶王历爽龙泽黄晓明林婉君张娜郑博文杨友钟芳芳申云富覃祥黄喆陈俊和林倩煜
Owner 杜晶晶
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