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"Sanhuang" heart-fire removing decoction formula granules and preparing method and detection method thereof

A technology of Sanhuang Xiexin Decoction and formula granules, which can be applied to the preparation of pharmaceutical formulas, test samples, medical preparations containing active ingredients, etc., and can solve problems such as the impact of drug efficacy

Active Publication Date: 2014-10-01
KANGMEI PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, single-flavored traditional Chinese medicine formula granules, directly ingested, have a certain impact on its efficacy.

Method used

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  • "Sanhuang" heart-fire removing decoction formula granules and preparing method and detection method thereof
  • "Sanhuang" heart-fire removing decoction formula granules and preparing method and detection method thereof
  • "Sanhuang" heart-fire removing decoction formula granules and preparing method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Preparation of Example 1 Sanhuang Xiexin Decoction Formula Granules

[0093] 1. Source of medicinal materials, as shown in Table 1 below.

[0094] Table 1

[0095]

[0096] 2. Instruments and equipment

[0097] B-290 Spray Dryer, Swiss Buqi Company; RE-5205 Rotary Evaporator, Shanghai Yarong Biochemical Instrument Factory.

[0098] 3. Preparation method

[0099] Get 10g of rhubarb, 5g of rhubarb rhizome, 5g of scutellaria baicalensis, soak in water, then decoct, filter, combine the filtrate, concentrate under reduced pressure at 70°C, and concentrate the filtrate to a clear paste with a relative density of 1.15 (60°C), spray dry, and the air inlet temperature is 160°C, air outlet temperature 80°C, pump speed 2%, dry to obtain dry extract powder; then put the dry extract powder into a dry granulator, granulate, and pack the granules separately, 3g per bag.

[0100] The specific conditions are shown in Table 2 below:

[0101] Table 2 Selection of decoction times...

Embodiment 2

[0124] Embodiment 2 Thin-layer chromatography identification embodiment 1 is A in process condition 2 B 3 C 2 made in three Huangxiexin Decoction Granules

[0125] 1. Identification of rhubarb in Sanhuang Xiexin Decoction Granules

[0126] 1.1 Medicinal materials and reagents

[0127] Rhubarb control medicinal material: batch number 110715-200212, purchased from China Institute for the Control of Pharmaceutical and Biological Products;

[0128] Test product: Sanhuang Xiexin Tang formula granules prepared according to the method described in Example 1, with batch numbers of 2011122601 and 2011122602, manufactured by Kangmei Pharmaceutical Co., Ltd.

[0129] Thin layer plate: silica gel G plate, purchased from Kangmei Pharmaceutical Co., Ltd.

[0130] 1.2 Test steps

[0131] The preparation of the first rhubarb test sample: Take 0.25g of this product, add methanol 5ml, ultrasonic treatment for 5 minutes, take the supernatant as the test solution.

[0132] Pr...

Embodiment 3

[0144] Embodiment 3 measures that embodiment 1 is A at process condition 2 B 3 C 2 Sanhuang Xiexin Decoction prepared at that time Fingerprints of square particles

[0145] 1. Instruments and reagents

[0146] 1.1 Instrument: High performance liquid chromatography: Agilent1100 series; Chromatographic column: Ecosil HPLC COLUM C18 (4.6×250mm, 5μm); Electronic analytical balance: XP-6; FA2104; Ultrasonic extractor: KQ-300VDB dual-frequency digital control ultrasonic cleaning instrument.

[0147] 1.2 Reagents: Methanol is chromatographically pure, water is ultrapure water; other reagents are analytically pure.

[0148]1.3 Reagent: Sanhuang Xiexin Decoction Formula Granules prepared according to the method described in Example 1, batch number 2011122602, and baicalin reference substance (National Institute for the Control of Pharmaceutical and Biological Products, batch number: 110715-200212).

[0149] 2. Chromatographic conditions and system adaptability The ch...

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Abstract

The invention provides "sanhuang" heart-fire removing decoction formula granules and a preparing method and a detection method thereof. The granules are prepared by adding water into rheum officinale, root of baikal skullcap and Chinese goldthread in a weight ratio of 2:1:1, decocting, filtering, and concentrating and drying filtrate. The detection method includes: identifying the granules by a thin-layer chromatography method; detecting a fingerprint spectrum of the granules by a high performance liquid chromatography method; detecting the extract content of the granules by a hot dipping method; and detecting the contents of compounds in the granules by a high performance liquid chromatography method. The "sanhuang" heart-fire removing decoction is prepared by mixed-decoction according to traditional methods, advantages of traditional Chinese medicine compatibility are fully exerted, the holism concept of traditional Chinese medicines is reflected, and effects of toxicity reducing and efficacy enhancing are achieved. Disadvantages brought by simple addition of medicines in a taking process of single-medicine formula granules at present are overcome. Process conditions and complete quality standards of the granules are established.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine. It specifically relates to a traditional Chinese medicine and its preparation method and detection method, in particular to a Sanhuang Xiexin Tang formula granule and its preparation method and detection method. Background technique [0002] Sanhuang Xiexin Decoction, also known as Dahuanghuanglian Xiexin Decoction, comes from the volume of Zhang Zhongjing's "Synopsis of the Golden Chamber". It is mainly used to treat internal blaze of evil fire, forcing blood to flow indiscriminately, vomiting blood, epistaxis, constipation and redness; or jaundice caused by internal dampness and heat. Accumulated heat in the three energizers, red and swollen eyes, sores on the mouth and tongue, external syndrome sores, dysphoria in the heart and chest, constipation; damp-heat jaundice, dysphoria and distension in the chest, yellow and greasy tongue coating, rapid and rapid pulse. Commonly used prepa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K9/16A61P31/00A61P29/00A61P1/04A61P7/04A61P9/00A61P3/08A61P9/10A61P3/04A61P1/10A61P1/02A61P11/02A61P27/02A61P11/04A61P1/00A61P1/12A61P17/02G01N30/90G01N30/02G01N30/36G01N30/06G01N1/28
Inventor 金维维许冬瑾马兴田向飞军吴小明陈有军
Owner KANGMEI PHARMA
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