Nuclear factor-kappaB polypeptide inhibitor and application thereof
A peptide inhibitor and nuclear factor technology, applied in the field of medicine, can solve the problems of inability to improve the condition and the time should not be too long, and achieve the effect of preventing or treating rheumatoid arthritis
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[0013] Immunoprotective Effects of Polypeptides in Collagen-Induced Mouse Arthritis Animal Model
[0014] A collagen-type mouse arthritis animal model was constructed to study the therapeutic effect of polypeptide on collagen-induced arthritis (CIA) in mice. Using mice as experimental animals, 90 SPF grade DBA / 1 mice (provided by Sino-British SIPPRLab.AnimalLtd), animal production license number: SCXK (Shanghai) 2008- 0016), male, 7-8 weeks old, with a body weight of 18-22g, were randomly divided into 9 groups, which were normal control group, model control group, 3 dosage groups of low, medium and high polypeptide (0.2, 0.4, 0.8mg / kg) and Positive drug control group (methotrexate 1mg / kg). Except the normal group, mice CIA models were established in each experimental group on the 0th day by dissolving chicken cartilage type II collagen (cII) with 0.1 mol / l acetic acid into a 4 mg / ml solution and overnight in a refrigerator at 4°C. On the day of the experiment, equal volumes ...
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