Tumor necrosis factor inhibitory polypeptide and application thereof
A technology of tumor necrosis factor and inhibitory peptide, applied in the field of medicine, can solve the problems of ineffective treatment, allergic reaction, neutralization, etc., and achieve the effect of preventing or treating rheumatoid arthritis
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Embodiment 1
[0011] Immunoprotective effect of tumor necrosis factor inhibitory polypeptide in collagen-induced mouse arthritis animal model
[0012] A collagen-type mouse arthritis animal model was constructed to study the therapeutic effect of tumor necrosis factor inhibitory polypeptide on collagen-induced arthritis (CIA) in mice. Using mice as experimental animals, 60 SPF grade DBA / 1 mice (provided by Sino-British SIPPRLab.AnimalLtd), animal production license number: SCXK (Shanghai) 2008- 0016), male, 7-8 weeks old, with a body weight of 18-22g, were randomly divided into 6 groups, which were normal control group, model control group, 3 dosage groups of low, medium and high polypeptide (0.4, 0.8, 1.6mg / kg) and Positive drug control group (methotrexate 2mg / kg). Except the normal group, mice CIA models were established in each experimental group on the 0th day by dissolving chicken cartilage type II collagen (cII) with 0.1 mol / l acetic acid into a 4 mg / ml solution and overnight in a re...
Embodiment 2
[0019] The immune protection effect of tumor necrosis factor inhibitory polypeptide on adjuvanted rat arthritis animal model in vivo
[0020] An animal model of adjuvant arthritis in rats was constructed to study the therapeutic effect of the polypeptide on Adjuvantarthritis (AA) rats. Rats were used as experimental animals, 60 SPF grade SD rats (provided by Shanghai SIPPR Lab. Animal Ltd, animal production license number: SCXK (Shanghai) 2008-0016) , male, body weight 140g-160g, were randomly divided into 6 groups, namely normal control group, model control group, 3 dose groups of low, medium and high tumor necrosis factor inhibitory polypeptide (0.2, 0.4, 0.8mg / kg) and positive drug control group (Methotrexate 1mg / kg). In addition to the normal group, on the 0th day, each experimental group established a rat AA model by injecting complete Freund's adjuvant containing inactivated Mycobacterium tuberculosis (H37RA, 10mg / ml) in the left rear of the rat. 0.1ml caused rat adjuv...
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