33results about How to "Significant effect in treating rheumatoid arthritis" patented technology

The invention discloses an application of a blocker with integrin affinity and bonding capability and MMPs (matrix metalloproteinases) inhibiting capability, and belongs to the field of medicines. The application comprises a polypeptide I (Arg-Gly-Asp-Gly-Gly-Gly-Gly-Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu) and a polypeptide II (Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu-Gly-Gly-Gly-Gly-Arg-Gly-Asp), wherein the polypeptide I is modified with an integrin ligand sequence (Arg-Gly-Asp-Gly-Gly-Gly-Gly); two types of blood vessel inhibiting polypeptides with integrin affinity and bonding capability are formed. The application has the advantages that because of the targeting property of an RGD (arginine-glycin-aspartate) sequence, the polypeptides can be targeted to the new blood vessel endothelium of the RA (rheumatoid arthritis) pannus forming process, the forming of MMPs (matrix metalloproteinases) and the new blood vessel can be inhibited, and the effect of preventing or treating the blood vessel and inflammatory diseases are realized; the polypeptides can be applied to the treatment of the blood vessel and inflammatory diseases, such as arthritis, inflammation, tumors, and eye diseases.

The invention relates to the field of medicines and in particular relates to a peripheral interleukin 35 polypeptide which can be used for preventing and treating rheumatoid arthritis. The sequence of the polypeptide is EAARTCSRLLTPSIHLISGAHVV and is brand-new. The polypeptide has the beneficial effects that the polypeptide can be used for treating rheumatoid arthritis and has potential new medicine development value.

The invention relates to the field of medicines, and in particular to a polypeptide which has an effect of inhibiting a rheumatoid factor IgA, and can be used for preventing and treating juvenile rheumatoid arthritis. The sequence of the polypeptide is EFVFLLKGHEDLRQDERVMQ which is a brand-new sequence. The polypeptide provided by the invention has the beneficial effects that the polypeptide can be used for treating the juvenile rheumatoid arthritis and has a potential new medicine development value.

The invention relates to the field of medicine, in particular to polypeptide inhibiting an interferon regulation factor 5. The sequence of the polypeptide is TCMIPRDTHDGAFYRA and is brand new. The polypeptide can prevent and treat rheumatoid arthritis. Rheumatoid arthritis diseases can be treated and prevented through various administration modes including subcutaneous or muscle injection, intravenous injection or intravenous infusion or oral administration such as pills, capsules and nasal spray. The polypeptide has the advantages that the polypeptide can be used for treating rheumatoid arthritis, and the polypeptide has potential new drug development value.

The invention relates to the field of drugs, particularly a polypeptide capable of inhibiting tumor necrosis factor and preventing and treating rheumatoid arthritis. The sequence is RINDISHTQSVSSKQKVTG and is a brand-new sequence. The polypeptide can be used for treating rheumatoid arthritis, and has potential new drug development value.