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Nuclear factor-KB polypeptide inhibitor 5 and application thereof

A peptide inhibitor, -KB technology, applied in the direction of peptides, anti-inflammatory agents, peptide/protein components, etc., to achieve the effect of preventing or treating rheumatoid arthritis

Inactive Publication Date: 2014-05-07
NANTONG CHENGXIN AMINO ACID
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Steroid hormones. Hormones are very good analgesic and anti-inflammatory drugs, but long-term use alone cannot improve the condition, but bring many side effects. Steroids can be used as a transitional second-line slow-acting drug before it takes effect, but the dosage should be limited. small, not too long
However, there are no well-developed nuclear factor-KB peptide inhibitors available for the treatment of RA

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The immunoprotective effect of nuclear factor-KB polypeptide inhibitor 5 in collagen-induced mouse arthritis animal model

[0016] To construct collagen mouse arthritis animal model, and study the therapeutic effect of nuclear factor-KB polypeptide inhibitor 5 on collagen induced arthritis (CIA) in mice. Mice were used as experimental animals, 90 SPF grade DBA / 1 mice (provided by Sino-British SIPPR Lab. Animal Ltd, animal production license number: SCXK (Shanghai )2008-0016), male, 7-8 weeks old, body weight 18-22 g, were randomly divided into 6 groups, namely the normal control group, the model control group, 3 low, middle and high dosage groups of peptide inhibitor 5 (0.4, 0.8 , 1.6 mg / kg) and positive drug control group (methotrexate 2 mg / kg). In addition to the normal group, the mouse CIA model was established in each experimental group on day 0 by dissolving chicken cartilage type II collagen (cII) with 0.1 mol / l acetic acid into a 4 mg / ml solution and placing it ...

Embodiment 2

[0021] Protective effect of nuclear factor-KB peptide inhibitor 5 on the immune protection of adjuvanted rat arthritis animal model in vivo

[0022] An animal model of adjuvant arthritis in rats was constructed to study the therapeutic effect of nuclear factor-KB polypeptide inhibitor 5 on adjuvant arthritis (AA) rats. Rats were used as experimental animals, 90 SPF grade SD rats (provided by Sino-British SIPPR Lab. Animal Ltd, animal production license number: SCXK (Shanghai) 2008 -0016), male, weighing 140 g-160 g, were randomly divided into 6 groups, namely the normal control group, the model control group, and 3 low, middle and high dose groups of nuclear factor-KB polypeptide inhibitor 5 (0.2, 0.4, 0.8 mg / kg) and positive drug control group (methotrexate 1 mg / kg). In addition to the normal group, on the 0th day, each experimental group established a rat AA model by injecting complete Freund's adjuvant containing inactivated Mycobacterium tuberculosis (H37RA, 10 mg / ml) in...

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PUM

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Abstract

The invention provides a nuclear factor-KB polypeptide inhibitor 5 and an application thereof, relates to the field of medicines, and particularly relates to a polypeptide which can inhibit the nuclear factor-KB and can be used for preventing and treating chronic infectious arthritis. The sequence is a brand-new sequence SHGGLPCQNS. The nuclear factor-KB polypeptide inhibitor 5 has the beneficial effects that the nuclear factor-KB polypeptide inhibitor 5 can be used for treating the chronic infectious arthritis and has a potential new medicine development value.

Description

[0001] Technical field: [0002] The invention relates to the field of medicines, in particular to nuclear factor-KB polypeptide inhibitors for preventing and treating or preventing rheumatoid arthritis. [0003] Background technique: [0004] Rheumatoid arthritis (RA) is the most common clinical inflammatory joint disease and one of the main disabling factors. It is about 0.5%-1.0% in the world, and the incidence of RA is about 0.4% in my country. RA can occur at any age, and the incidence rate increases with age. The high-incidence age of women is 45-55 years old, and gender is closely related to the incidence of RA, with a male-to-female ratio of about 1:3. RA is a chronic systemic inflammatory disease of unknown etiology, with chronic, symmetrical, polysynovial arthritis and extra-articular lesions as the main clinical manifestations, and belongs to autoimmune inflammatory disease. Patients often have hand or wrist pain and swelling (especially the swelling on the ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K38/08A61P29/00A61P19/02
Inventor 邢将军许刘华彭立军任世阔华俊国曹铭刘加根刘明明汪士金施新华刘伟峰严明
Owner NANTONG CHENGXIN AMINO ACID
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