Polypeptide inhibiting interferon regulation factor 5 and application thereof

A technology for inhibiting polypeptides and regulatory factors, applied in the field of interferon regulatory factor 5 polypeptide inhibitory polypeptides, can solve the problems of not being able to improve the condition, the time should not be too long, etc., and achieve the effect of preventing or treating rheumatoid arthritis

Inactive Publication Date: 2015-11-18
SUZHOU PULUODA BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Steroid hormones. Hormones are very good analgesic and anti-inflammatory drugs, but long-term use alone cannot improve the condition, but bring many side effects. Steroids can be used as a transitional second-line slow-acting drug before it takes effect, but the dosage should be limited. small, not too long
However, there is no well-developed interferon regulatory factor 5 inhibitory polypeptide available for the treatment of RA

Method used

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  • Polypeptide inhibiting interferon regulation factor 5 and application thereof
  • Polypeptide inhibiting interferon regulation factor 5 and application thereof
  • Polypeptide inhibiting interferon regulation factor 5 and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Immunoprotective effect of interferon regulatory factor 5 inhibitory polypeptide in collagen-induced mouse arthritis animal model

[0013] A collagen-type mouse arthritis animal model was constructed to study the therapeutic effect of interferon regulatory factor 5 inhibitory polypeptide on collagen-induced arthritis (CIA) in mice. Using mice as experimental animals, 60 SPF grade DBA / 1 mice (provided by Sino-British SIPPRLab.AnimalLtd), animal production license number: SCXK (Shanghai) 2008- 0016), male, 7-8 weeks old, with a body weight of 18-22g, were randomly divided into 6 groups, which were normal control group, model control group, 3 dosage groups of low, medium and high polypeptide (1, 2, 4mg / kg) and positive Drug control group (methotrexate 2mg / kg). Except the normal group, mice CIA models were established in each experimental group on the 0th day by dissolving chicken cartilage type II collagen (cII) with 0.1 mol / l acetic acid into a 4 mg / ml solution and overn...

Embodiment 2

[0021] Protective effect of interferon regulatory factor 5 inhibitory polypeptide on the in vivo immune protection of adjuvanted rat arthritis animal model

[0022] An animal model of adjuvant arthritis in rats was constructed to study the therapeutic effect of the polypeptide on Adjuvantarthritis (AA) rats. Rats were used as experimental animals, 60 SPF grade SD rats (provided by Shanghai SIPPR Lab. Animal Ltd, animal production license number: SCXK (Shanghai) 2008-0016) , male, body weight 140g-160g, were randomly divided into 6 groups, namely normal control group, model control group, 3 dose groups of low, middle and high doses of interferon regulatory factor 5 inhibitory polypeptide (0.5, 1, 2mg / kg) and positive drug control group (methotrexate 1mg / kg). In addition to the normal group, on the 0th day, each experimental group established a rat AA model by injecting complete Freund's adjuvant containing inactivated Mycobacterium tuberculosis (H37RA, 10mg / ml) in the left rea...

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PUM

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Abstract

The invention relates to the field of medicine, in particular to polypeptide inhibiting an interferon regulation factor 5. The sequence of the polypeptide is TCMIPRDTHDGAFYRA and is brand new. The polypeptide can prevent and treat rheumatoid arthritis. Rheumatoid arthritis diseases can be treated and prevented through various administration modes including subcutaneous or muscle injection, intravenous injection or intravenous infusion or oral administration such as pills, capsules and nasal spray. The polypeptide has the advantages that the polypeptide can be used for treating rheumatoid arthritis, and the polypeptide has potential new drug development value.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to an interferon regulatory factor 5 polypeptide inhibitory polypeptide for preventing and treating or preventing rheumatoid arthritis. Background technique: [0002] Interferon regulatory factor (IRF) is a family of transcription factors that can regulate the expression of interferon and interferon-induced genes by interacting with the cis-element (ISRE) in the interferon gene, and plays an important role in the regulation of interferon genes. status. Interferon regulatory factor-5 is a member of this family. IRF5 can induce the production of IFN-α and IFN-β, and can also promote the production of IL-6, IL-12b, IL-17, IL-23, TNF and other cytokines. Secreted, thus participating in the body's immune response, cell growth, cell differentiation, apoptosis, tumorigenesis and cell signal transduction and other processes. Interferon regulatory factor-5 plays an important role in the occurrence...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08A61K38/10A61P19/02A61P29/00
Inventor 罗瑞雪
Owner SUZHOU PULUODA BIOLOGICAL SCI & TECH
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