Nuclear factor-KB polypeptide inhibitor and application thereof
A polypeptide inhibitor and nuclear factor technology, applied in the direction of peptides, anti-inflammatory agents, peptide/protein components, etc., to achieve the effect of preventing or treating rheumatoid arthritis
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Embodiment 1
[0015] The effect of nuclear factor-κB polypeptide inhibitor 1 on the swelling degree of left paw in mice with collagen type arthritis. Compared with each other, there were extremely significant differences (P<0.01), and the experimental results were statistically significant. The effect of nuclear factor-κB polypeptide inhibitor 1 on the swelling degree of the right paw of mice with collagen type arthritis, the diameter of the right hind ankle of the positive control group, the nuclear factor-κB polypeptide inhibitor 1 high, medium and low dose groups and the model group There were extremely significant differences (P<0.01), and the experimental results were statistically significant. The effect of nuclear factor-KB polypeptide inhibitor 1 on the clinical scores of mice with collagen-type arthritis, the scores of limbs in the low-, medium-, and high-dose polypeptide 1 groups were significantly lower than those in the model control group (P<0.01), which was extremely significa...
Embodiment 2
[0021] The effect of nuclear factor-κB polypeptide inhibitor 1 on the paw swelling degree of rats with primary arthritis, the left hind ankle diameter of the positive control group, low, medium and high dose groups of nuclear factor-κB polypeptide inhibitor 1 Compared with the model group, there was a very significant difference (P<0.01); the diameter of the left hind ankle of the nuclear factor-κB polypeptide inhibitor 1 low, middle and high dose groups was significantly different from that of the model group (P<0.05 ), the experimental results are statistically significant. The effect of nuclear factor-κB polypeptide inhibitor 1 on the paw swelling degree of rats with secondary arthritis, the diameter of right hind ankle in the positive control group, nuclear factor-κB polypeptide inhibitor 1 low, medium and high dose groups Compared with the model group, there was a significant difference (P<0.05). The effect of nuclear factor-κB polypeptide inhibitor 1 on the clinical sco...
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