Nuclear factor-KB polypeptide inhibitor and application thereof

A polypeptide inhibitor and nuclear factor technology, applied in the direction of peptides, anti-inflammatory agents, peptide/protein components, etc., to achieve the effect of preventing or treating rheumatoid arthritis

Inactive Publication Date: 2014-05-28
NANTONG CHENGXIN AMINO ACID
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Steroid hormones. Hormones are very good analgesic and anti-inflammatory drugs, but long-term use alone cannot improve the condition, but bring many side effects. Steroids can be used as a transitional second-line slow-acting drug before it takes effect, but the dosage should be limited. small, not too long
However, there are no well-developed nuclear factor-κB peptide inhibitors available for the treatment of RA

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The effect of nuclear factor-κB polypeptide inhibitor 1 on the swelling degree of left paw in mice with collagen type arthritis. Compared with each other, there were extremely significant differences (P<0.01), and the experimental results were statistically significant. The effect of nuclear factor-κB polypeptide inhibitor 1 on the swelling degree of the right paw of mice with collagen type arthritis, the diameter of the right hind ankle of the positive control group, the nuclear factor-κB polypeptide inhibitor 1 high, medium and low dose groups and the model group There were extremely significant differences (P<0.01), and the experimental results were statistically significant. The effect of nuclear factor-KB polypeptide inhibitor 1 on the clinical scores of mice with collagen-type arthritis, the scores of limbs in the low-, medium-, and high-dose polypeptide 1 groups were significantly lower than those in the model control group (P<0.01), which was extremely significa...

Embodiment 2

[0021] The effect of nuclear factor-κB polypeptide inhibitor 1 on the paw swelling degree of rats with primary arthritis, the left hind ankle diameter of the positive control group, low, medium and high dose groups of nuclear factor-κB polypeptide inhibitor 1 Compared with the model group, there was a very significant difference (P<0.01); the diameter of the left hind ankle of the nuclear factor-κB polypeptide inhibitor 1 low, middle and high dose groups was significantly different from that of the model group (P<0.05 ), the experimental results are statistically significant. The effect of nuclear factor-κB polypeptide inhibitor 1 on the paw swelling degree of rats with secondary arthritis, the diameter of right hind ankle in the positive control group, nuclear factor-κB polypeptide inhibitor 1 low, medium and high dose groups Compared with the model group, there was a significant difference (P<0.05). The effect of nuclear factor-κB polypeptide inhibitor 1 on the clinical sco...

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PUM

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Abstract

The invention relates to the field of medicines, particularly to polypeptide which restrains the nuclear factor-KB, and can be used for preventing and treating chronic infectious arthritis. The sequence is KRSGGGFPAAV and is a bran-new sequence. The invention has the benefits that the nuclear factor-KB polypeptide inhibitor is capable of treating the chronic infectious arthritis and has potential value in development of new medicaments.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to a nuclear factor-κB polypeptide inhibitor used for preventing and treating or preventing rheumatoid arthritis. Background technique: [0002] Rheumatoid arthritis (RA) is the most common clinical inflammatory joint disease and one of the main disabling factors. It is about 0.5%-1.0% in the world, and the incidence of RA is about 0.4% in my country. RA can occur at any age, and the incidence rate increases with age. The high-incidence age of women is 45-55 years old, and gender is closely related to the incidence of RA, with a male-to-female ratio of about 1:3. RA is a chronic systemic inflammatory disease of unknown etiology, with chronic, symmetrical, polysynovial arthritis and extra-articular lesions as the main clinical manifestations, and belongs to autoimmune inflammatory disease. Patients often have hand or wrist pain and swelling (especially the swelling on the back of the w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06A61K38/08A61P29/00A61P19/02
Inventor 邢将军许刘华彭立军任世阔华俊国曹铭刘加根刘明明汪士金施新华刘伟峰严明
Owner NANTONG CHENGXIN AMINO ACID
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