A double-stranded polynucleotide-ε-polylysine complex with immunoregulatory effect and its preparation and use method

A double-stranded polynucleotide and polylysine technology, applied in biochemical equipment and methods, medical preparations containing active ingredients, microorganisms, etc., can solve problems such as antibiotic residues and achieve strong resistance to biological enzymatic degradation , Improving immune regulation activity, and the effect of simple preparation process
CN105664152BActive Publication Date: 2019-01-18北京加益维科生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
北京加益维科生物科技有限公司
Publication Date
2019-01-18

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Abstract

The invention provides a double-strand oligonucleotide-epsilon-polylysine compound with an immune regulation function and a preparation and use method of the double-strand oligonucleotide-epsilon-polylysine compound and also provides immunogen composition with functions of triggering immunoenhancement reaction and changing the immunoreaction type and a preparation and use method of the immunogen composition. The immunogen composition comprises the double-strand oligonucleotide-epsilon-polylysine compound and an antigen. The compound contains a compound formed through composition of double-stranded polynucleotide, a cation epsilon-polylysine and metal cations. The compound has the pharmacological activity of immunoregulation. The preparation process of the compound is simple. The compound has good water solubility and a bio-enzyme degradation resisting function. The immunogen composition can trigger the immunoenhancement reaction and change the immunoreaction type.
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Description

technical field

[0001] The present invention relates to the field of medicine, specifically, the present invention provides a double-stranded polynucleotide-ε-polylysine complex with immune regulation function and its preparation and use method. The present invention also provides an immunogen composition capable of triggering and enhancing immune response and changing the type of immune response and its preparation and use method. Background technique

[0002] 1. Double-stranded polynucleotide: Double-stranded polynucleotide or its derivatives have various pharmacological activities, and the source is natural extraction or artificial synthesis. Artificially synthesized double-stranded polynucleotides such as polyinocytic (polyI:C) can induce the production of interferon in the body, protect cells from virus infection, and have curative effects such as preventing and treating viral diseases; naturally extracted double-stranded polynucleotides such as Viral double-stranded R...

Claims

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