Composition with anti-inflammatory effect and its preparation method and use

A technology of anti-inflammatory effect and composition, which is applied in the field of anti-inflammatory composition and its preparation, which can solve problems such as climbing organ performance, poor wound healing, and organ function concealment, so as to achieve good anti-inflammatory effect and protect the heart and lungs tissue, reducing ear swelling

Active Publication Date: 2019-08-23
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, excessive exudate often causes the function of related organs to be hidden. For example, pleural effusion can suppress the lungs and cause difficulty in breathing; , but often establish adhesions or hard change of parenchymal organs, which seriously impairs the performance of this organ
[0006] Therefore, in clinical practice, anti-inflammatory treatment is often required. Conventional anti-inflammatory drugs include dexamethasone, etc. However, long-term use of dexamethasone and other hormone western medicines will cause a large number of side effects, such as iatrogenic Cushing's syndrome Facial appearance and posture, weight gain, lower extremity edema, purple streaks, bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, osteoporosis and fractures, muscle weakness, muscle atrophy, hypokalemia Syndrome, gastrointestinal irritation, pancreatitis, peptic ulcer or perforation, growth inhibition in children, glaucoma, cataract, benign elevated intracranial pressure syndrome, impaired glucose tolerance and exacerbation of diabetes

Method used

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  • Composition with anti-inflammatory effect and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A composition with anti-inflammatory effect, prepared by the following method:

[0032] 1. Prepare raw materials.

[0033] Put the whole cherry fruit into an oven at 60°C, bake for 24-48 hours, take it out, and cool to room temperature. Take the dried cherries and put them into a pulverizer to pulverize them into fine grains to obtain the dried cherries.

[0034] Put Cordyceps militaris in an oven at 60°C, bake for 24-48 hours, take it out, and cool to room temperature. Take the dried Cordyceps militaris and put them into a pulverizer to pulverize into fine grains to obtain the dried Cordyceps militaris.

[0035] Two, extraction.

[0036] Take 100g dried cherry and 100g dried Cordyceps militaris respectively, place them in a 2000ml round bottom flask, add 8ml ethanol aqueous solution according to the amount of each gram of raw material (that is, the ratio of material to liquid is 1:8), and the volume percentage is 95% % ethanol aqueous solution 1600ml, reflux extrac...

experiment example

[0046] The extract prepared by above-mentioned embodiment and comparative example is carried out anti-inflammatory experiment, and specific method is as follows:

[0047] 1. Method.

[0048] 1. Administration.

[0049]Mice with a body weight of 18-22g were randomly divided into positive group (administered with dexamethasone), negative group (administered with saline), water layer extract group, ethyl acetate layer extract group A, petroleum ether layer Extract group, ethyl acetate layer extract group B, ethyl acetate layer extract group C, ethyl acetate layer extract group D, 10 mice in each group.

[0050] They were administered by subcutaneous injection at a dose of 10mg / 20g for 5 days.

[0051] 2. Anti-inflammatory test.

[0052] (1), prepare croton oil.

[0053] Croton oil prescription: 2% croton oil, 20% absolute ethanol, 78% ether (volume ratio) preparation.

[0054] (2), method.

[0055] On the 5th day after the administration of the mice, 1 hour after the admini...

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Abstract

The invention relates to a composition with anti-inflammatory function and a preparation method and application thereof and belongs to the technical field of natural products. The active constituents of the composition are prepared from the following materials in percent by weight: 40%-60% of dried Nanking cherry and 60%-50% of dried Cordyceps militaris. Nanking cherry and Cordyceps militaris are coordinated according to the aforementioned proportion, the two creates collaborative effect, giving extraordinary anti-inflammatory action, and the composition is prepared using the natural traditional Chinese medicine that are both medicinal and edible as raw material and has the advantages of low side effect and high safety.

Description

technical field [0001] The invention relates to the technical field of natural products, in particular to a composition with anti-inflammatory effect and its preparation method and application. Background technique [0002] Inflammation is a very common and important basic pathological process. It refers to the defense response of living tissue with vascular system to damage factors. Pain and dysfunction. It can be either infectious inflammation caused by infection or non-infectious inflammation not caused by infection. [0003] During the inflammatory process, on the one hand, the damage factors directly or indirectly cause tissue and cell destruction, and on the other hand, the damage factors are diluted, killed and surrounded by inflammatory hyperemia and exudative reactions. At the same time, damaged tissues can be repaired and healed through the regeneration of parenchymal and interstitial cells. Therefore, it can be said that inflammation is a unified process of inj...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61P29/00
CPCA61K36/068A61K36/736A61K2236/333A61K2236/35A61K2300/00
Inventor 张成义王曼力陈曦师继超
Owner BEIHUA UNIV
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