Composition for inhibiting oxidative damage of biological cells and application thereof

A cell oxidation and biological cell technology, which can be used in drug combinations, medical preparations containing active ingredients, antidote, etc., can solve problems such as differences in antioxidant effects, and achieve the effect of reducing oxidative stress and improving antioxidant effects.

Inactive Publication Date: 2016-11-23
JIANGSU POLYTECHNIC COLLEGE OF AGRI & FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the difference in molecular structure, different antioxidants are distributed differently in cells, so their antioxidant effects are very different

Method used

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  • Composition for inhibiting oxidative damage of biological cells and application thereof
  • Composition for inhibiting oxidative damage of biological cells and application thereof
  • Composition for inhibiting oxidative damage of biological cells and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] An anti-oxidative damage mixture (that is, a composition for resisting oxidative damage to biological cells), comprising the following components in parts by weight: 3 parts of vitamin C, 6 parts of vitamin E, and 20 parts of R-(+)-lipoic acid. Add the above-mentioned mixture according to 200 mg / L to subculture in vitro into the 2-3 generation newborn pig skeletal muscle satellite cell culture medium.

Embodiment 2

[0023] An anti-oxidative damage mixture comprises the following components in parts by weight: 4 parts of vitamin C, 8 parts of vitamin E, and 24 parts of R-(+)-lipoic acid. Add the above-mentioned mixture according to 200 mg / L to subculture in vitro into the 2-3 generation newborn pig skeletal muscle satellite cell culture medium.

Embodiment 3

[0025] An anti-oxidative damage mixture comprises the following components in parts by weight: 2 parts of vitamin C, 4 parts of vitamin E, and 16 parts of R-(+)-lipoic acid. Add the above-mentioned mixture according to 200 mg / L to subculture in vitro into the 2-3 generation newborn pig skeletal muscle satellite cell culture medium.

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PUM

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Abstract

The invention discloses a composition for inhibiting oxidative damage of biological cells and application thereof. The composition comprises vitamin C, vitamin E and R-(+)-lipoic acid, wherein the mass ratio of vitamin C to vitamin E to R-(+)-lipoic acid is 1: (1-3): (1-12). The invention also provides application of the composition for inhibiting free radical oxidation damage of biological cells in non-treatment purpose. According to the composition for inhibiting oxidative damage of biological cells provided by the invention, due to the synergistic effect among the vitamin C, vitamin E and R-(+)-lipoic acid, the composition is capable of improving the antioxidant effect and can be used for inhibiting free radical oxidation damage of biological cells in non-treatment purpose. Specifically, the composition has an antioxidant protection effect for porcine skeletal muscle satellite cells and can achieve an effect of reducing oxidative stress of porcine skeletal muscle satellite cells.

Description

technical field [0001] The invention relates to an anti-oxidative damage mixture, in particular to a composition for resisting free radical oxidative damage of biological cells and its application. Background technique [0002] Under the normal physiological state of the animal body, oxygen free radicals are constantly produced and eliminated at the same time. Therefore, the oxygen free radicals in the animal body have been maintained at a low level and will not have adverse effects on the body. However, many exogenous or endogenous stimuli can break the balance of redox in the body and tend to oxidize, and the generation of oxygen free radicals will increase significantly, showing great damage to the body. Oxidative stress often leads to decreased production performance of livestock and poultry, decreased quality of animal products, and even animal diseases. Antioxidants are widely used in livestock production. [0003] Skeletal muscle satellite cells are myogenic stem ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/385A61K31/375A61K31/355A61P39/06
CPCA61K31/385A61K31/355A61K31/375A61K2300/00
Inventor 汪善锋李凌云史俊徐超席刚俊杨鹤同
Owner JIANGSU POLYTECHNIC COLLEGE OF AGRI & FORESTRY
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