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Application of medicine compositions with sarpogrelate to treating or preventing fatty livers, liver fibrosis and/or liver injury

A technology of sargrelate, medicine, applied in the field of medicine

Active Publication Date: 2016-12-07
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] At present, there are no reports on the use of serotonin 2 receptor antagonist sarcogrelate and / or serotonin synthesis inhibitors for the treatment or prevention of fatty liver, liver fibrosis, and liver damage

Method used

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  • Application of medicine compositions with sarpogrelate to treating or preventing fatty livers, liver fibrosis and/or liver injury
  • Application of medicine compositions with sarpogrelate to treating or preventing fatty livers, liver fibrosis and/or liver injury
  • Application of medicine compositions with sarpogrelate to treating or preventing fatty livers, liver fibrosis and/or liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] 1 part by weight of sagrelate, 5 parts by weight of p-chlorophenylalanine, and commonly used auxiliary materials such as dextrin to prepare granules using conventional techniques.

Embodiment 2

[0117] 1 part by weight of sagogrelate, 2 parts by weight of p-chlorophenylalanine, and microcrystalline cellulose and other commonly used auxiliary materials are compressed into tablets.

Embodiment 3

[0119] 2 parts by weight of sagrelate, 1 part by weight of p-chlorophenylalanine, and commonly used auxiliary materials such as dextrin are made into granules using conventional techniques, and then poured into hard capsule skins to make capsules.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and discloses application of medicine compositions with sarpogrelate to treating or preventing fatty livers, liver fibrosis and / or liver injury. As proved from experiments, the application has the advantages that the fatty livers due to high fat and high cholesterol can be obviously reversed by the aid of the medicine compositions, and the liver fibrosis and the liver injury due to combination effects of the high fat, the high cholesterol and streptozotocin irritation can be obviously reversed.

Description

Technical field [0001] The invention belongs to the field of medicine, and relates to the use of a pharmaceutical composition containing sagrelate for the treatment or prevention of fatty liver, liver fibrosis and / or liver injury, and specifically relates to a serotonin 2 receptor antagonist sagrelate and The use of a compound pharmaceutical composition of a combination of a serotonin synthesis inhibitor for treating or preventing fatty liver, liver fibrosis and / or liver injury. Background technique [0002] Fatty liver is directly manifested by obvious lipid deposits in the liver. A significant increase in triglyceride (TG) content in liver tissue can be detected. Obvious lipid droplets in liver cells can be observed in tissue sections. Further liver disease can develop into liver fibrosis and liver damage. Liver fibrosis can be determined by observing the formation of liver fibrous tissue by special staining of tissue sections and detecting the content of hydroxyproline (a uni...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/225A61P1/16A61P3/06A61K31/198A61K31/165
CPCA61K31/165A61K31/198A61K31/225A61K45/06A61K2300/00
Inventor 傅继华
Owner CHINA PHARM UNIV