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New application of growth differentiation factor 15 in assessing first-episode stroke in hypertensive patients

A technology of growth differentiation factor and ischemic stroke, applied in the field of prevention of cardiovascular and cerebrovascular diseases, can solve the problems of lack of prospective research

Active Publication Date: 2018-04-17
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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AI Technical Summary

Problems solved by technology

Most of these prior art studies focus on stroke patients or animal models, lacking prospective studies
As for whether GDF15 can predict the occurrence of stroke, there is no relevant research

Method used

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  • New application of growth differentiation factor 15 in assessing first-episode stroke in hypertensive patients
  • New application of growth differentiation factor 15 in assessing first-episode stroke in hypertensive patients
  • New application of growth differentiation factor 15 in assessing first-episode stroke in hypertensive patients

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Experimental program
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Effect test

Embodiment

[0035] 1. Research population

[0036] From March to August 2010, 271 adult hypertensive patients without stroke history were selected from the Hypertension Community Research Base of Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences in Xinyang City, Henan Province. The diagnosis of hypertension is based on the World Health Organization's criteria for diagnosing hypertension, that is, under quiet conditions, measure the blood pressure of both upper limbs at three different times within 2 months, systolic blood pressure ≥ 140mmHg and / or diastolic blood pressure ≥ 90mmHg; Take blood pressure medication. The investigation process includes: ①questionnaire basic information and medical history, traditional risk factors such as smoking and drinking; ②measurement of sitting blood pressure in both upper limbs; ③taking fasting venous blood samples; ④taking urine samples; ; ⑥Medical auscultation and physical examination; ⑦12-lead electrocardiogram; ⑧Echocardiography. ...

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Abstract

The invention discloses a novel use of a novel use of growth-differential factor 15 (GDF15) in assessment of first cerebral stroke of a hypertension patient. The GDF15 is used as a marker for assessment of a first cerebral stroke risk of a subject to be detected. The invention also provides a use of a reagent for detecting a GDF15 level in a detection agent or detection system for assessment of a first cerebral stroke risk of a subject to be detected and also provides a detection system for assessment of a first cerebral stroke risk of a subject to be detected. A hypertension cohort population perspective research proves that the hypertensive patient with a high baseline blood plasma GDF15 level has a high risk of first cerebral stroke and cerebral ischemic stroke.

Description

technical field [0001] The present invention relates to a new application of an endogenous secretory protein, more specifically to a new application of growth-differentiation factor 15 (growth-differential factor 15, GDF15) in assessing the first stroke of hypertensive patients, which belongs to cardiovascular and cerebrovascular the field of disease prevention. Background technique [0002] my country is a country with a high incidence of stroke, with more than 2.5 million new cases each year (China Health Statistical Yearbook 2002-2012). Stroke has become the first cause of death and the first cause of adult disability in our country. The number of deaths due to stroke exceeds 1.7 million every year, and there are about 10 million survivors after stroke, with a disability rate as high as 75%. Severe disability exceeds 40% (Lancet, 2013:381(9882):1987-2015). The total hospitalization expenses for the treatment of stroke in my country exceeds 45 billion yuan each year (Chi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/6812
Inventor 王晓建惠汝太孙凯
Owner FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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