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Application of cyclic dinucleotide cGAMP to treatment of tumors through drug combination

A cyclic dinucleotide and anti-tumor technology, which is applied in the field of biomedicine and achieves the effect of good application prospects

Inactive Publication Date: 2017-01-04
LIAOCHENG CITY ORIENT BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no literature report on the combined use of cyclic dinucleotide cGAMP and traditional cytotoxic antineoplastic drugs in the treatment of tumors

Method used

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  • Application of cyclic dinucleotide cGAMP to treatment of tumors through drug combination
  • Application of cyclic dinucleotide cGAMP to treatment of tumors through drug combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 ： Preparation of cGAMP

[0019] cGAMP is catalyzed and synthesized by cyclized dinucleotide synthetase (cGAS) under activation conditions after binding to DNA according to the literature method, and the purity is above 98%. (PingweiLi, et al., Immunity, 2013, 39(6), 1019-1031.)

Embodiment 2

[0020] Example 2 ： Anti-tumor animal experiment of cGAMP combined with chemotherapeutic drugs

[0021] The tumor-bearing mouse model was used to detect the inhibitory effect of cGAMP combined with antineoplastic drugs on the growth of subcutaneous transplanted tumors in animals and the toxic effect on animals.

[0022] 1. Animals

[0023] Healthy male F1 mice of Kunming White hybrid Babl / c, weighing 20-25 g, were reared in groups of 10 mice / cage, divided into 10 groups in total. Purchased from Shanghai Slack Experimental Animal Co., Ltd., quality certificate number (animal certificate number: SCXK (Shanghai) 2007-0005). Raised in a clean animal room.

[0024] 2. Drugs

[0025] drug factory Fluorouracil Shanghai Xudong Haipu Pharmaceutical Co., Ltd. cyclophosphamide Jiangsu Shengdi Pharmaceutical Co., Ltd. methotrexate Qilu Pharmaceutical Co., Ltd. Cisplatin Qilu Pharmaceutical Co., Ltd. Carboplatin Qilu Pharmaceutical Co., ...

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PUM

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Abstract

The invention discloses application of cyclic dinucleotide cGAMP to prevention and treatment of tumors through drug combination, belonging to the technical field of biological medicine. The invention also discloses a plurality of drug compositions for prevention and treatment of tumors. The drug compositions for prevention and treatment of tumors are composed of cyclic dinucleotide and one selected from a group consisting of fluorouracil, cyclophosphamide, methotrexate, cisplatin, carboplatin, paclitaxel, vincristine, mitomycin, gemcitabine and actinomycin. Results of in-vivo research show that the drug compositions composed of cyclic dinucleotide and one selected from a group consisting of fluorouracil, cyclophosphamide, methotrexate, cisplatin, carboplatin, paclitaxel, vincristine, mitomycin, gemcitabine and actinomycin have obviously improved curative effect and obviously decreased toxicity.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a new application of cyclic dinucleotide cGAMP in combined drug therapy for preventing and treating tumors. Background technique [0002] Malignant tumor is a common and frequently-occurring disease that seriously threatens human health and has become an important cause of human death. At present, the main treatment methods for tumors include drug therapy, surgery and radiation therapy. Although new anti-tumor drugs represented by molecular targeted drugs are constantly emerging, traditional cytotoxic anti-tumor drugs still occupy a dominant position in the drug treatment of tumors for a considerable period of time. [0003] Traditional cytotoxic antineoplastic drugs directly inhibit tumor cell proliferation or induce tumor cell apoptosis by affecting the nucleic acid and protein structure and function of tumor cells. Although people have made a lot of efforts in the drug t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/7084A61P35/00
Inventor 不公告发明人
Owner LIAOCHENG CITY ORIENT BIOMEDICAL TECH CO LTD
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