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Traumatic brain injury and neurodegenerative biomarkers, methods, and systems

A traumatic brain injury, biomarker technology, applied in biological testing, biological material analysis, instruments, etc., can solve the problems of high cost and difficult to obtain

Inactive Publication Date: 2017-02-22
IRON HORSE DIAGNOSTICS
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Imaging (CT or MRI) is an objective test of brain injury and is not sensitive or specific enough, or is too costly as a clinical tool to identify the extent of brain injury, and is not readily available as a screening tool

Method used

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  • Traumatic brain injury and neurodegenerative biomarkers, methods, and systems
  • Traumatic brain injury and neurodegenerative biomarkers, methods, and systems
  • Traumatic brain injury and neurodegenerative biomarkers, methods, and systems

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Embodiment

[0029] Methods for diagnosing mTBI. One embodiment involves detecting the levels of biomarkers in a sample obtained from a subject and comparing the levels of these biomarkers to those of patients known to have mTBI, moderate or severe TBI, or patients without brain damage. Predetermined levels are associated. Biomarkers include one or more of the following: ubiquitin C-terminal hydrolase L1 (UCH-L1), glial markers such as glial fibrillary acidic protein (GFAP), aldehyde dehydrogenase 1 family member L1 (ALDH1L1 ) and other glial proteins, phosphorylated neurofilament heavy chain (pNFH), phosphorylated neurofilament medium chain or phosphorylated neurofilament light chain (pNFM and light chain (pNFL)), α-synuclein, opsin Like protein 1 (VILIP-1) and S100B.

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Abstract

Biomarkers, methods, and systems for assessment of traumatic brain injury of different severities, as well as treatment efficacy and blood brain barrier or blood cerebrospinal fluid integrity and assessment of neurodegenerative conditions. The methods include detecting in a patient sample one or more of ubiquitin C-terminal hydrolase LI (UCH-L1), glial fibrillary acid protein (GFAP), aldehyde dehydrogenase 1 family member LI (ALDHILI), phosphorylated neurofilament heavy chain (pNFH), medium chain (NFM), or light chain (NFL), alpha-synuclein, visinin-like protein 1 (VILIP-1) and S100B.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application No. 61 / 976,380, filed April 7, 2014. technical field [0003] The present invention relates to biomarkers, methods and systems for diagnosing and otherwise assessing indicators of traumatic brain injury and neurodegenerative disease. Background technique [0004] Advances in the genome in recent years have dramatically improved our understanding of the molecular changes that advance outcomes in pathology. Technological innovations in the proteome have translated this knowledge into the pace of rapid discovery of potential biomarkers for early detection and prognosis of different disorders. [0005] Traumatic brain injury is a complex condition caused by mild to severe head injuries, and approximately 1.4 million US citizens will suffer brain injuries this year, with one to four million sports-related concussions each year. Traumatic brain injury...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53
CPCG01N33/6896G01N2800/52G01N2800/2814G01N2800/2821G01N2800/2835G01N2800/285
Inventor 罗伯特·鲍瑟尔安德烈亚斯·赫罗米诺格里·肖
Owner IRON HORSE DIAGNOSTICS
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