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Pulse-activating compound extract and application in preparation of medicine or health product for improving memory

A technology for improving memory and extracts, applied in the field of biomedicine, can solve the problems of less products and affecting the quality of life, etc., and achieve the effect of improving memory impairment, improving memory function, and improving memory

Inactive Publication Date: 2017-05-17
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Physiological memory impairment can seriously affect people's quality of life, and there is an urgent need for effective memory-improving drugs or health products, but unfortunately there are few products in this area

Method used

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  • Pulse-activating compound extract and application in preparation of medicine or health product for improving memory
  • Pulse-activating compound extract and application in preparation of medicine or health product for improving memory
  • Pulse-activating compound extract and application in preparation of medicine or health product for improving memory

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 Maimai compound extract

[0026] Materials: Ginseng, Ophiopogon japonicus, and Schisandra were purchased from Huirentang Pharmaceutical Chain Co., Ltd., Lanzhou, Gansu Province.

[0027] The raw materials of the Shengmai compound extract include ginseng, Ophiopogon japonicus, and Schisandra chinensis, and the weight ratio of ginseng, Ophiopogon japonicus, and Schisandra chinensis is 3:2:1.

[0028] Weigh 120g of ginseng, 80g of Ophiopogon japonicus, and 40g of Schisandra chinensis, soak in 2400ml of absolute ethanol for 0.5h, heat and reflux twice for 2.5h each time, filter, and concentrate under reduced pressure to obtain Shengmai compound extract. Ethanol is fully evaporated, and after drying, the extract of Shengmai Compound is obtained.

Embodiment 2

[0029] Example 2 The platform jumping test of Shengmai compound extract improving memory in normal mice

[0030] 1. Experimental drugs and reagents

[0031] Preparation of Shengmai Compound Extract (SM): Prepare Shengmai Compound Extract according to the preparation method described in Example 1, weigh 300 mg of Shengmai Compound Extract and dissolve it in 20 ml of distilled water to prepare a suitable concentration of Shengmai Compound Extract Compound extract (SM), the concentration is 15mg / ml.

[0032] Preparation of the positive drug (P): Weigh 150 mg of the content of the oxiracetam capsule and dissolve it in 20 ml of distilled water to prepare a 15 mg / ml solution.

[0033] 2. Experimental animals

[0034] Female clean-grade Kunming mice were purchased from the GLP Experimental Animal Center of Lanzhou University, weighing 20.0±2.0g; 50 animals were selected from 70 mice for the platform jumping experiment.

[0035] 3. Main instruments: electronic balance (0.0001g), YL...

Embodiment 3

[0051] Example 3 Shengmai Compound Extract Improves Memory Avoidance Experiment in Normal Mice

[0052] 1. Experimental drugs and reagents

[0053]Prepare each group of solutions with the method shown in Example 2. In the figure, C is the blank control group; P is the positive drug oxiracetam group.

[0054] 2. Experimental animals

[0055] Female clean-grade Kunming mice, purchased from the GLP Experimental Animal Center of Lanzhou University, weighing 20.0±2.0g; 75 animals were selected from 120 mice for the water maze experiment

[0056] 3. Main instruments:

[0057] Electronic balance (0.0001g), YLS-17 dark avoidance shuttle (Chengdu Taimeng Technology Co., Ltd.).

[0058] 4. Implementation steps

[0059] (1) Breeding of Kunming mice

[0060] Healthy adult female mice with basically the same body weight were kept at a temperature of 18-22° C. and a humidity of 50%-60%. Give 12h sunshine and 12h nightlight at the same time.

[0061] (2) Screening of experimental anim...

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Abstract

The invention discloses a pulse-activating compound extract and a preparation method thereof and application of the pulse-activating compound extract in the preparation of a medicine and a health product for improving memory. The pulse-activating compound extract comprises the following raw medicinal materials: ginseng, radix ophiopogonis, and Chinese magnoliavine. The weight ratio of ginseng to radix ophiopogonis to Chinese magnoliavine is 3:2:1. After alcohol extraction of the pulse-activating formula, dysmnesia caused by scopolamine can be improved, and memory function of normal Kunming mouse can be remarkably improved. The pulse-activating compound extract can be applied in the preparation of a medicine and a health product for improving memory.

Description

technical field [0001] The invention relates to a preparation method and application of a Shengmai compound extract, in particular to the application of the Shengmai compound extract in preparing memory-improving medicines or health care products, and belongs to the field of biomedicine. [0002] technical background [0003] The so-called memory is the process of memorizing, retaining and applying people's experience. It is the process of selecting, encoding, storing and extracting information. function. Scientific research has found that on the one hand, human memory gradually declines with age; nutrition and energy supply. If you can't guarantee its needs, it will also cause a rapid decline in memory. These are all physiological memory loss phenomena rather than pathological memory loss. Physiological memory impairment can seriously affect people's quality of life, and there is an urgent need for effective memory-improving medicines or health products, but unfortunately...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A23L33/00A61P25/28
Inventor 李红玉高春红支德娟
Owner LANZHOU UNIVERSITY
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