Biomarkers of Hypercoagulation State and Its Application

A state-marking and hypercoagulable technology, applied in the field of biomarkers of hypercoagulation state, can solve problems such as no research reports on urine biomarkers
CN107290552BActive Publication Date: 2019-05-14BEIJING NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING NORMAL UNIVERSITY
Publication Date
2019-05-14

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Abstract

The invention discloses a biomarker having a high-blood coagulation status and an application of same. In the invention, three different blood coagulation promoting drugs (etamsylate, tranexamic acid and aminocaproic acid) are employed to respectively intervene in blood coagulation status of adult rats, thus successfully obtaining an adult rat acute high-blood coagulation status model; and then change on urine proteomes of the adult rats in intervention groups with different blood coagulation promoting drugs is analyzed; for the first time, the change feature of the urine proteomes under the high-blood coagulation status is systematically researched, and a biomarker, which is related to the high-blood coagulation status, is found in the urine. The invention initially discloses body intervention range and change factors of the high-blood coagulation status, which not only prompt related physiological and pathological mechanisms and the change feature of a signal pathway, but also are applied as an important biomarker in detection and / or diagnosis for related pathological change of the high-blood coagulation status or supply assistant information to the aspect.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and in particular relates to a biomarker of a hypercoagulation state and an application thereof. Background technique

[0002] When the body is stimulated by physiological or pathological factors, it will produce a series of changes, and the changes that can be monitored are called biomarkers. The most fundamental characteristic of a biomarker is change. When the body is stimulated, the original balance in the body is broken, cells, tissues and organs will produce some abnormal metabolites and excrete them from the body to restore the original balance and maintain the homeostasis of the internal environment. Compared with blood, urine can accumulate a large number of changes because it is not regulated by the body's homeostasis mechanism, and can better reflect changes in the body, and is a good source of biomarkers. At the same time, urine has the advantages of large volume, non-invasiveness, and ...

Claims

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