Application of indacaterol in the treatment of colorectal cancer

A technology for colorectal tumors and tumors, applied in the field of molecular biology and tumor treatment, can solve the problems of proving the therapeutic effect, reducing cancer lesions, and no animal experiments
CN107582550BActive Publication Date: 2019-11-01ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2019-11-01

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Abstract

The invention discloses an application of indacaterol in the treatment of colorectal cancer, and belongs to the field of molecular biology, in particular, tumor treatment. Specifically, indacaterol selected from disclosed drugs can treat colorectal cancer. The results of cell experiments and animal experiments show that indacaterol can inhibit the proliferation, invasion and migration of colorectal tumor cell lines, and can obviously reduce the size of colorectal tumors of a mouse model. At the same time, for the first time, people find that indacaterol corrects the alternative splicing of tumor cells to achieve the effects mentioned above.
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Description

technical field

[0001] The invention belongs to the field of molecular biology, in particular to the field of tumor treatment, and relates to a series of therapeutic drugs screened according to markers specifically expressed in colorectal cancer. Specifically, the present invention utilizes gene alternative splicing for the first time to screen a drug for treating colorectal cancer, specifically, the drug is Indacaterol. Background technique

[0002] Colorectal cancer is one of the malignant tumors that poses a great threat to human survival and health in the world today, ranking third in the cancer death spectrum in western developed countries. In my country, with the change of residents' lifestyle and dietary structure, the incidence of colorectal cancer is increasing at an annual rate of 4%, and the average annual growth rate is 2 percentage points higher than that of the world.

[0003] The Human Genome Project found that the human body has about 23,000 genes, far fewer...

Claims

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