New application of BICC1 protein in mental disease diagnosis

Abstract

The invention discloses application of reagents for detecting BICC1 protein content in the preparation of mental disease diagnosis products. Researches discover that BICC1 protein has differential expression in the serum of people with schizophrenia, unipolar depressive disorder, bipolar mania, bipolar depression and panic disorder and in the serum of people, without mental diseases, in a controlgroup (the expression of the BICC1 protein is increased in the serum of the people with the schizophrenia, the unipolar depressive disorder, the bipolar mania, the bipolar depression and the panic disorder). By using the BICC1 protein as the index, a brand new approach for detecting the schizophrenia, the unipolar depressive disorder, the bipolar mania, the bipolar depression and the panic disorder is provided, AUC (area under curve) under an ROC curve is 0.714-1.0, and a high diagnosis value is achieved.

Description

technical field [0001] The invention relates to the field of biological sciences, and more specifically, relates to a new application of BICC1 protein in the diagnosis of mental diseases. Background technique [0002] Schizophrenia / Unipolar Depressive Disorder / Bipolar Mania / Bipolar Depression / Panic Disorder can lead to serious adverse social and personal consequences. Usually, the onset of schizophrenia / unipolar depressive disorder / bipolar mania / bipolar depression / panic disorder is difficult to detect clinically, and it usually takes a long time until the clinical symptoms appear or are diagnosed. Most of the family members have experienced both economic and psychological suffering. Therefore, it is of great significance to prevent the further progression of the disease and reduce the physical and mental suffering and economic burden of patients and their families through early diagnosis and early treatment. [0003] The clinical diagnostic methods of schizophrenia / unipola...

AI Technical Summary

Problems solved by technology

[0003] The clinical diagnostic methods of schizophrenia / unipolar depressive disorder / bipolar mania / bipolar depression / panic disorder have always been irreplaceable clinical symptomological standards, such as China's "Chinese Classification and Diagnostic Criteria for Mental Disorders (Third Edition )" (CCMD-3), "International Classification of Diseases, Tenth Revision" (ICD-10), "Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition" (DSM-IV), "Diagnostic and Statistical Manual of Mental Disorders" (Fifth Edition)" (DSM-5), etc., but the method itself has serious shortcomings: subjectivity, high rate of misdiagnosis

The detection of BICC1mRNA in the brain is not easy, but peripheral blood is easily available, but there is no report on the expression level of BICC1 in the serum of patients with schizophrenia / unipolar depression / bipolar mania / bipolar depression / panic disorder

Images