Uses of Wuzi Yanzong Pills

A technology of Wuzi Yanzong pills and uses, which is applied to medical preparations containing active ingredients, pill delivery, and pharmaceutical formulas, and can solve problems such as large side effects and poor curative effect in preventing recurrence

Active Publication Date: 2021-06-08
SHANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relevant studies at home and abroad have shown that hormones and immunosuppressants are the first-choice drugs currently used in the clinical treatment of MS, which not only have relatively large side effects, but also have poor efficacy in preventing recurrence.

Method used

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  • Uses of Wuzi Yanzong Pills
  • Uses of Wuzi Yanzong Pills
  • Uses of Wuzi Yanzong Pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Experimental method

[0029] 1. EAE model preparation

[0030] The oligodendrocyte myelin glycoprotein polypeptide segment 35-55 is prepared into a water preparation with physiological saline, and Mycobacterium tuberculosis is prepared into an oil preparation with complete Freund's adjuvant. Use a needle mixer to mix the oil preparation and the water preparation according to 1: 1 ratio is fully mixed to make a water-in-oil antigen emulsion, and it can be regarded as qualified if there is no delamination after standing. Inject the antigen emulsion (MOG) at 4 points on both sides of the 4-5 vertebrae 35-55The concentration of TB is 250 μg / mouse, the concentration of TB is 350 μg / mouse), and each mouse is subcutaneously injected with 0.1 mL of antigen emulsion. On the day of immunization and 48 hours later, mice in each group were intraperitoneally injected with pertussis toxin, 300 ng each time. The onset of EAE started when the mice showed symptoms of decreased mus...

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PUM

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Abstract

The invention discloses the application of Wuzi Yanzong Pills. The Wuzi Yanzong Pill of the present invention is used as a medicine for treating multiple sclerosis. The present invention applies Wuzi Yanzong Pills to intervene EAE mice, explores its preventive effect and mechanism, provides experimental basis for the clinical application of the method of tonifying kidney and replenishing essence to prevent and treat multiple sclerosis, and effectively proves that Wuzi Yanzong Pills can be used as a drug for treating multiple sclerosis.

Description

technical field [0001] The invention relates to the use of Wuzi Yanzong Pills, in particular to the use of Wuzi Yanzong Pills as a medicine for treating multiple sclerosis, and belongs to the field of traditional Chinese medicine. Background technique [0002] Multiple sclerosis (multiple ltiple ltiple sclerosis, MS) is an autoimmune disease mediated by T cells, and T cells play a key role in the inflammatory response of demyelination. Its pathogenesis can be summarized as a certain inducement to activate T cells, enter the brain and spinal cord through the blood-brain-barrier (BBB), combine with central antigens, secrete a large number of cytokines and chemokines, and further make peripheral Blood T cells, B cells, monocytes / macrophages, etc. enter the inflammatory site, damage the central nervous tissue, and cause a demyelinating inflammatory reaction. The high-incidence group of MS is the young and middle-aged, and the disability rate is very high. Relevant studies at h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61K9/20A61P25/00A61P37/02
Inventor 柴智樊慧杰张若楠李艳彦周然肖保国马存根
Owner SHANXI UNIV OF CHINESE MEDICINE
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