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Implants Including An Oxysterol And Methods Of Use

A technology of implants and oxysterols, which is applied in the direction of bone implants, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as the inability to provide biological agents

Active Publication Date: 2018-02-09
WARSAW ORTHOPEDIC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This can be problematic in achieving effective bone growth in and through the desired implant volume due to scaffold particle migration or separation
Additionally, implant materials do not provide effective slow release of biologics to treat bone defects

Method used

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  • Implants Including An Oxysterol And Methods Of Use
  • Implants Including An Oxysterol And Methods Of Use
  • Implants Including An Oxysterol And Methods Of Use

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0285] A first formulation of a moldable implant having the composition shown in Table 1 was prepared.

[0286] Table 1

[0287] CMC%

[0288] The values ​​listed in Table 2 refer to the composition of the dry powder components of the matrix before wetting with physiologically acceptable saline. Carboxymethylcellulose is added to impart adhesive properties to the implant. Carboxymethylcellulose has also been found to cause significant expansion of the implant after wetting. In some instances, carboxymethylcellulose expanded the implant to twice the size of the dry compound in some dimensions. The collagen added to the composition is porcine type I fibrotic collagen. The ceramic contains beta tricalcium phosphate and hydroxyapatite in a ratio of 85:15. The ceramic particles have a particle size of about 125 μm to about 750 μm. Small particles preferably yield a larger surface area to volume ratio to achieve faster absorption after implantation in a bone defect. ...

example 2

[0290] Formulations of moldable implants having the compositions shown in Table 2 were prepared.

[0291] Table 2

[0292] Collagen%

[0293] The values ​​listed in Table 2 refer to the composition of the powder components of the matrix before wetting with physiologically acceptable saline. After wetting, the collagen was found to hold the implant together with little or no cross-linking. The collagen added to the composition is porcine type I fibrotic collagen. The ceramic contains beta tricalcium phosphate and hydroxyapatite in a ratio of 85:15. The ceramic particles have a particle size of about 125 μm to about 750 μm. Small particles preferably yield a larger surface area to volume ratio to achieve faster absorption after implantation in a bone defect. A relatively high amount of ceramic is provided into the composition to impart compression resistance properties. The amount of Oxy133 added to the composition was about 400 mg / cc. Oxy133 was added in the for...

example 3

[0295] Compositions were prepared according to the specifications of Example 1 or 2 above. The composition is moistened with sterile water.

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Abstract

Provided is a malleable implant configured to fit at or near a bone defect site to promote bone growth, the malleable implant comprising: a biodegradable polymer, mineral particles, and an oxysterol,the implant configured to become moldable upon being wetted with a fluid. Methods of making and use are further provided.

Description

[0001] Cross References to Related Applications [0002] This application is co-pending U.S. Patent Application Serial No. 14 / 796,625 filed July 10, 2015, co-pending U.S. Patent Application Serial No. 14 / 796,601 filed July 10, 2015, July 2015 PCT application of co-pending U.S. patent application serial number 14 / 796,564 filed on June 10, 2015 and co-pending U.S. patent application serial number 14 / 741,673 filed on June 17, 2015 and requiring the priority. These applications are incorporated herein by reference in their entirety. Background technique [0003] Biologics are often used to promote bone growth in medical applications, including fracture healing and surgical management of spinal conditions. Spinal fusions are often performed by orthopedic surgeons and neurosurgeons, for example, to address degenerative disc disease and arthritis affecting the lumbar and cervical spine, to correct deformation caused by scoliosis, and to repair instability caused by spondylolisthes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/50A61K31/56
CPCA61L27/54A61K9/5031A61L27/14A61L2430/02A61K31/575A61L27/46A61L2300/43A61P19/00A61F2/28A61L27/3608A61L27/446A61L27/58A61F2002/30677A61F2002/30062A61F2002/2835A61L2300/222A61L2300/62
Inventor B·T·里夫斯D·S·谢尔S·J·德拉皮尔R·E·哈林顿J·C·雅各布斯
Owner WARSAW ORTHOPEDIC INC
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