Unlock instant, AI-driven research and patent intelligence for your innovation.

Anti-tumor compounds, and preparation method and application thereof

A compound, anti-tumor technology, applied in the field of disease and tumor-related diseases

Inactive Publication Date: 2018-03-06
NANJING UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing anti-tumor drugs are still far from meeting the needs of the growing cancer patients, so anti-tumor drugs are still an important direction for research and development

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-tumor compounds, and preparation method and application thereof
  • Anti-tumor compounds, and preparation method and application thereof
  • Anti-tumor compounds, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0243] The detection of embodiment 2 series compound antitumor activity

[0244] 1. Study on the activity of a series of compounds against mouse S180 ectopic tumors

[0245] (1) Cell type: S180 cells, from the Cell Resource Center of Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences.

[0246] (2) Mice type: SPF-grade ICR mice were purchased from the Animal Experiment Center of Yangzhou University.

[0247] (3) S180 tumor cells count live cells by red blood cell counting board, and then adjust the cells to 1×10 7 / ml, inoculated subcutaneously in the right forelimb armpit of mice (0.1ml / mouse), observed the growth of tumor-bearing mice every day, when the tumor diameter (diameter=(long diameter+short diameter) / 2) reached 0.5cm, the tumor-bearing Tumor mice were randomly divided into groups: tumor-bearing control group, serial compound treatment group (40mg / kg), 10 mice in each group. Each treatment group was administered by intratumoral injection, once ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to the field of organic synthesis and pharmaceutical chemistry and particularly relates to a series of compounds, and a preparation method and an anti-tumor application thereof.The invention discloses the series of compounds with anti-tumor activity, the preparation method of the compounds and the application of the compounds for preparing anti-tumor drugs. The formulae of the series of compounds are shown in the description. The series of compounds are synthesized by means of an organic synthesizing method. Activity tests find that the series of compounds have strong anti-tumor activity, and have an application prospect in preparing anti-tumor drugs. The compound 21# has wide inhibiting action on tumors, for example, liver cancer, lung cancer, gastric cancer, intestinal cancer, breast cancer, lymphoma, kidney cancer, pancreatic cancer, ovarian cancer, prostatic cancer, brain tumor, sarcoma, carcinoma of urinary bladder, melanoma and the like, and has a very goodapplication prospect.

Description

technical field [0001] The invention belongs to the technical field of medicinal chemistry, and specifically relates to a new anti-tumor compound, a drug combination containing the compound and its use for treating or preventing diseases such as tumors and diseases related to tumors. Background technique [0002] Tumor is a kind of disease that seriously endangers human health. According to the report of WHO, in 2005, more than 700 million people in the world died of cancer. In my country, tumors are the second leading cause of death among residents. The study of tumors has become the focus of human society and the focus of medical research in the 21st century. At present, tumor chemotherapy has made some progress, and the therapeutic effect on tumors is exact and obvious, but it still has not achieved immune curative effect. Therefore, in order to obtain effective and safe antitumor agents suitable for patients with cancer, great efforts have been made and are still being ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C313/06C07C311/09C07C233/33C07C233/76C07C303/40C07C303/38C07C231/02A61P35/00
CPCC07C231/02C07C233/33C07C233/76C07C303/38C07C303/40C07C311/09C07C313/06
Inventor 韩建林董磊梅海波张峻峰潘毅
Owner NANJING UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com