Optical sources for fluorescent lifetime analysis

A technology of pulsed light sources and light pulses, which is applied in the field of light sources for fluorescence lifetime analysis, and can solve the problems that cannot be incorporated into handheld devices and drive electronic devices.

Active Publication Date: 2018-03-27
QUANTUM SI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such laser systems and their drive electronics can be difficult to incorporate into an instrument as a replaceable module, or even impossible to incorporate into a handheld device

Method used

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  • Optical sources for fluorescent lifetime analysis
  • Optical sources for fluorescent lifetime analysis
  • Optical sources for fluorescent lifetime analysis

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Embodiment Construction

[0057] I. Introduction

[0058] The inventors have recognized and appreciated that commonly used ultrashort pulse sources with pulse repetition rates below 1 GHz are generally large, expensive and unsuitable for many mobile applications. For example, commonly used ultrashort pulse lasers cannot be incorporated into compact and portable instruments. The inventors have recognized and appreciated that small short or ultrashort pulse light sources can enable new and useful devices for a wide range of time domain applications. Such applications include but are not limited to time-of-flight imaging, ranging, fluorescence analysis and fluorescence lifetime analysis, biological or chemical analysis, optical coherence tomography optical coherence tomography (OCT) and medical point-of-care (POC, point-of-care )instrument. In some cases, a POC instrument may include a device for detecting fluorescence from a biological sample and analyzing the fluorescence to determine the nature of th...

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Abstract

Compact optical sources and methods for producing short and ultrashort optical pulses are described. A semiconductor laser or LED (2-423) may be driven with a bipolar waveform to generate optical pulses with FWHM durations as short as approximately 85 ps having suppressed tail emission. The pulsed optical sources may be used for fluorescent lifetime analysis of biological samples and time-of-flight imaging, among other applications.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to U.S. Provisional Application No. 62 / 164,485, filed May 20, 2015, entitled "Pulsed Laser," and filed August 7, 2015, entitled " U.S. Application No. 14 / 821,656, filed February 17, 2016, for "Integrated Device for Temporal Binning of Received Photons" for "Integrated Device for Temporal Binning of Received Photons" entitled "For Lifetime Imaging and Detection U.S. Provisional Application No. 62 / 296,546 for Sensors and Devices for Lifetime Imaging and Detection Applications” and titled “Pulsed Laser and System” filed on March 18, 2016 US Provisional Application No. 62 / 310,398, each of which is incorporated by reference in its entirety into this application. technical field [0003] The present application relates to devices and methods for generating short and ultrashort light pulses for time-domain applications including fluorescence lifetime and time-of-flight ranging applications. Ba...

Claims

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Application Information

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IPC IPC(8): H01S5/042H05B33/08H05B44/00
CPCH01S5/0428H01S5/0265H01S5/0602H01S5/06216H01S5/22H01S5/3086G01J11/00G01J3/4406
Inventor乔纳森·M·罗斯伯格杰森·W·希克勒罗伦斯·C·威斯特F·艾哈迈德布兰登·黄保罗·E·格伦J·C·舒尔茨J·卡马拉
OwnerQUANTUM SI