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A built-in biological kit and its preparation method and application

A technology of normal saline and water for injection, applied in the field of tissue engineering of biomedical materials, can solve the problems of undetected specific effects, different effects, complicated operations, etc., to prolong ejaculation latency, reduce sensitivity, and improve sexual life quality Effect

Active Publication Date: 2021-01-15
BEIJING JAYYALIFE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the middle of the 1980s, autologous fat injections began to be used to thicken the penis, but due to the different fat preparations, injection methods and injection volumes, the effects are also different, so the controversy is relatively large
However, these materials are generally expensive except for silicone rubber prostheses, and some methods are more complicated to operate
Although these techniques are occasionally reported, the specific effects have not yet been found in statistics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1 Preparation method of acellular allogeneic dermal matrix

[0070] Put allogeneic leather raw materials into 0.3g / L phospholipase and 0.1g / L trypsin solution, the pH value of the enzyme solution is 7.0, the temperature is 37°C, shake at 100rpm for 2 hours, replace the enzyme solution once, repeat this process once, The semi-finished product A is obtained; the phospholipase is a mixture of phospholipase A1: phospholipase A2: phospholipase C: phospholipase D according to the mass ratio of 1:1:1:1.

[0071] The semi-finished product A was taken out, put into a container filled with physiological saline solution, soaked in physiological saline, oscillated 3 times, each time for 2 hours, the oscillation speed was 80 rpm, and the temperature was 2°C to obtain the semi-finished product B.

[0072] Put the semi-finished product B into the solution containing 0.2g / LTritonX-100, 50KHz, 220W, ultrasonic for 5 minutes, soak for 3 hours, repeat this process 3 times, and get...

Embodiment 2

[0078] Example 2 Preparation method of acellular allogeneic dermal matrix

[0079] Put allogeneic leather raw materials into 0.2g / L phospholipase and 0.2g / L trypsin solution, the pH value of the enzyme solution is 7.0, the temperature is 37°C, shake at 100rpm for 2 hours, replace the enzyme solution once, repeat this process once, The semi-finished product A is obtained; the phospholipase is a mixture of phospholipase A1, phospholipase A2, phospholipase C and phospholipase D according to the mass ratio of 1:1:1:1.

[0080] The semi-finished product A was taken out, put into a container filled with physiological saline solution, soaked in physiological saline, oscillated 3 times, each time for 2 hours, the oscillation speed was 80 rpm, and the temperature was 2°C to obtain the semi-finished product B.

[0081] Put the semi-finished product B into a solution containing 0.2g / LSDS, 10mM EDTA, 50KHz, 220W, ultrasonic for 7 minutes, soak for 2 hours, repeat this process 3 times, and...

experiment example 1

[0089] Experimental example 1 Acellular allogeneic dermal matrix (built-in biological sleeve) used in dorsal nerve isolation surgery

[0090] Surgical method: After nerve block anesthesia at the root of the penis, the foreskin is circumcised for those with excessive prepuce, and for those who have undergone circumcision, a 3-5cm long skin incision is made along the original incision on the dorsal side of the penis. The superficial fascia and deep fascia were incised sequentially until the buffy membrane was fully exposed. Carefully separated to the coronary sulcus, the acellular allogeneic dermal matrix was prepared as required into a built-in biological sleeve and sutured and fixed on the buffy membrane, the distal end was to the coronal sulcus, and the urethra was not surrounded on both sides. The fascia and skin were sutured layer by layer. The penis is moderately pressurized and bandaged.

[0091] Postoperative treatment:

[0092] 1. The penis is moderately pressurized ...

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Abstract

The invention relates to a built-in biological sleeve and its preparation method and application. To provide suitable built-in biological sleeve materials for dorsal nerve isolation surgery and penis thickening surgery, the present invention prepares a new acellular allogeneic dermal matrix material and makes it into a built-in biological sleeve, which can be used for the treatment of premature ejaculation and short penis. The acellular allogeneic dermal matrix or built-in biological sheath of the present invention is used for dorsal nerve isolation surgery, penis thickening or lengthening surgery without cutting off the dorsal nerve, thereby avoiding the possibility of psychological erectile dysfunction caused by patients' concerns about cutting off the dorsal nerve.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering of biomedical materials, and in particular relates to a built-in biological cover and its preparation method and application. Background technique [0002] Premature ejaculation (PE, premature ejaculation) is one of the clinically common andrological diseases, and the incidence rate accounts for 14%-41% of adult males. It seriously affects the quality of sexual life, not only causes great harm to the body and mind of the majority of patients, but also threatens the relationship between husband and wife and family harmony. In the past, the cause of premature ejaculation was considered to be caused by mental and psychological factors, such as depression, high mental tension and other factors, but recent research results have shown that some premature ejaculation has neuropathic organic lesions, that is, hyperesthesia of the glans penis or sensory nerve excitement of the glans penis. Sex ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/50
CPCA61L27/3633A61L27/3687A61L27/3691A61L27/50A61L2430/32A61L2430/34A61L27/362A61L2430/40
Inventor 孙继煌王海曾昂白明张海林王伟李雪银刘文进李卫强石清东
Owner BEIJING JAYYALIFE BIOTECH CO LTD
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