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A traditional Chinese medicine composition for enhancing the sensitivity of esophageal cancer to chemotherapeutic drugs and its application

A chemotherapeutic drug, esophageal cancer technology, applied in the directions of drug combination, pharmaceutical formula, antitumor drug, etc., to achieve the effect of small formula, easy popularization and application, and definite curative effect

Active Publication Date: 2020-11-10
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surgery and chemotherapy are commonly used treatment methods, but the clinical effective response rate to chemotherapy is only 19%-40%. Tumor drug resistance has become the main obstacle in the treatment of esophageal cancer

Method used

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  • A traditional Chinese medicine composition for enhancing the sensitivity of esophageal cancer to chemotherapeutic drugs and its application
  • A traditional Chinese medicine composition for enhancing the sensitivity of esophageal cancer to chemotherapeutic drugs and its application
  • A traditional Chinese medicine composition for enhancing the sensitivity of esophageal cancer to chemotherapeutic drugs and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The traditional Chinese medicine composition used to enhance the sensitivity of esophageal cancer to chemotherapeutic drugs in this embodiment consists of the following components in parts by weight: 22 parts of Danshen, 17 parts of Curcuma, 12 parts of Fritillaria, 12 parts of Chenpi, Pinellia 12 parts, 7 parts of licorice.

[0033] The application of the traditional Chinese medicine composition of this embodiment in enhancing the sensitivity of esophageal cancer to chemotherapeutic drugs comprises the following steps:

[0034] 1) Mix the components in the formula amount and grind them, then add 20 mL of water to every 1 g of traditional Chinese medicine, soak the crushed Chinese medicine in water for 1 hour, boil with strong fire and turn to slow fire for 30 minutes, filter out the medicine residue, and get decoction liquid;

[0035] 2) Add ethanol to the decoction until the volume fraction of ethanol is 75%, shake well for 24 hours, then centrifuge, take the superna...

Embodiment 2

[0037] The traditional Chinese medicine composition used to enhance the sensitivity of esophageal cancer to chemotherapeutic drugs in this embodiment consists of the following components in parts by weight: 18 parts of Danshen, 13 parts of Curcuma, 8 parts of Fritillaria, 8 parts of Chenpi, Pinellia 8 parts, 3 parts of licorice.

[0038] The application of the traditional Chinese medicine composition of this embodiment in enhancing the sensitivity of esophageal cancer to chemotherapeutic drugs comprises the following steps:

[0039] 1) Mix the components in the formula amount and grind them, then add 20 mL of water to every 1 g of traditional Chinese medicine, soak the crushed Chinese medicine in water for 1 hour, boil with strong fire and turn to slow fire for 30 minutes, filter out the medicine residue, and get decoction liquid;

[0040] 2) Add ethanol to the decoction liquid until the volume fraction of ethanol is 75%, shake well for 24 hours, then centrifuge, take the sup...

Embodiment 3

[0043] The traditional Chinese medicine composition used to enhance the sensitivity of esophageal cancer to chemotherapeutic drugs in this embodiment consists of the following components in parts by weight: 20 parts of Danshen, 15 parts of Curcuma, 10 parts of Fritillaria, 10 parts of Chenpi, Pinellia 10 parts, 5 parts of licorice.

[0044] The application of the traditional Chinese medicine composition of this embodiment in enhancing the sensitivity of esophageal cancer to chemotherapeutic drugs comprises the following steps:

[0045]1) Mix the components in the formula amount and grind them, then add 30mL of water to every 1g of traditional Chinese medicine, soak the crushed Chinese medicine in water for 1 hour, boil it over a strong fire and turn it to a slow fire for 30 minutes, filter out the medicine residue, and get the decoction liquid;

[0046] 2) Add ethanol to the decoction liquid until the volume fraction of ethanol is 75%, shake well for 24 hours, then centrifuge...

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Abstract

The invention relates to a traditional Chinese medicine composition for enhancing the sensitivity of esophagus cancer to chemotherapy drugs and application thereof, and belongs to the technical fieldof traditional Chinese medicine. The traditional Chinese medicine composition for enhancing the sensitivity of esophagus cancer to chemotherapy drugs mainly comprises the following components in partsby weight: 18 to 22 parts of the root of red-rooted salvia, 13 to 17 parts of radix curcumae, 8 to 12 parts of Thunberg Fritillary Bulb, 8 to 12 parts of dried tangerine or orange peel, 8 to 12 partsof Pinellia ternate and 3 to 7 parts of liquorice. The traditional Chinese medicine composition has an anticancer effect, and particularly can enhance the sensitivity of esophagus cancer to chemotherapy drugs, so that the inhibition ratio and killability for esophagus cancer cells are improved, the drug resistance of esophagus cancer cells to chemotherapy drugs is changed, the effect of clinic treatment is improved, and the death rate of esophagus cancer patients is reduced.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for enhancing the sensitivity of esophageal cancer to chemotherapeutic drugs and an application thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] Esophageal cancer is one of the common malignant tumors. There are about 250,000 newly diagnosed cases of esophageal cancer in my country every year, accounting for half of the number of esophageal cancer cases in the world. The five-year survival rate is less than 15%. Surgery and chemotherapy are commonly used treatment methods, but the clinical effective response rate to chemotherapy is only 19%-40%. Tumor drug resistance has become the main obstacle in the treatment of esophageal cancer. [0003] Esophageal cancer belongs to the category of "choking diaphragm" disease in traditional Chinese medicine. From the perspective of the functional characteristics of the esophagus, which "pass...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P35/00
CPCA61K36/484A61K36/537A61K36/752A61K36/8888A61K36/8966A61K36/9066A61K2236/331A61K2300/00
Inventor 吴耀松郭现辉陈玉龙彭贵军任闪闪
Owner HENAN UNIV OF CHINESE MEDICINE
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