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Traditional Chinese medicine formula and oral liquid for treating hand-foot-and-mouth disease, preparation method and application

A technology for hand, foot, and mouth disease and oral liquid, which is applied in the fields of medical formula, medical preparations containing active ingredients, drug delivery, etc. It can solve problems such as unclear quality control indicators, inconvenient clinical use, and unstable drug efficacy. The effect of reasonable and clear medicinal material ratio, clear and controllable preparation quality index, and less prescription of Chinese medicinal materials

Inactive Publication Date: 2018-04-20
SUZHOU SCI&TECH TOWN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the adverse reactions of antiviral drugs are serious, and the abuse of antibiotics has become a hazard. Traditional Chinese medicine has unique advantages in treating this disease, but most of them use large compound decoctions, which is inconvenient for clinical use. The indicators are not clear and the drug effect is unstable

Method used

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  • Traditional Chinese medicine formula and oral liquid for treating hand-foot-and-mouth disease, preparation method and application
  • Traditional Chinese medicine formula and oral liquid for treating hand-foot-and-mouth disease, preparation method and application
  • Traditional Chinese medicine formula and oral liquid for treating hand-foot-and-mouth disease, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Soak honeysuckle, scutellaria baicalensis, bupleurum, and cicada slough in water for 20 minutes, decoct twice, add water 9 times the weight of medicinal materials for the first time, decoct for 30 minutes, filter; add water 7 times the amount of medicinal materials for the second time, decoct 30 minutes, filter; combine the filtrate, concentrate to contain 0.5g total crude drug per ml, add 3 times the amount of 95% ethanol, stir slowly and quickly, let stand for 24 hours, filter; recover ethanol from the filtrate until the liquid has no alcohol smell, and get a clear ointment .

Embodiment 2

[0033] Example 2: Soak honeysuckle, scutellaria baicalensis, bupleurum, and cicada slough in water for 30 minutes, decoct twice, add water 6 times the weight of the medicinal materials for the first time, decoct for 40 minutes, filter; add water 4 times the amount of medicinal materials for the second time, decoct Filtrate for 50 minutes; combine the filtrates, concentrate to contain 1.2g total crude drug per ml, add 3 times the amount of 95% ethanol, stir slowly and quickly, let stand for 24 hours, filter; recycle the ethanol from the filtrate until the liquid has no alcohol smell, and get a clear ointment .

Embodiment 3

[0034] Example 3: Soak honeysuckle, scutellaria baicalensis, bupleurum, and cicada slough in water for 20 minutes, decoct twice, add water 14 times the weight of the medicinal materials for the first time, decoct for 20 minutes, filter; add water 6 times the amount of the medicinal materials for the second time, decoct Filtrate for 20 minutes; combine the filtrates, concentrate to contain 2.5g total crude drug per ml, add 3 times the amount of 95% ethanol, stir slowly and quickly, let stand for 24 hours, filter; recycle the ethanol from the filtrate until the liquid has no alcohol smell, and get a clear ointment .

[0035] (2) Pilot test:

[0036] According to the weight ratio of honeysuckle: scutellaria: Bupleurum: cicada slough 16:13:8:8, 16:8:4:4, 16:16:4:4, three batches of about 50 kg were extracted respectively, and the final extraction rate of active ingredients was 60%. % above, the result is as follows:

[0037] Table 1. Three batches of extraction pilot test result...

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Abstract

The invention relates to a traditional Chinese medicine formula and oral liquid for treating hand-foot-and-mouth disease, preparation method and application. According to the formula, the traditionalChinese medicine comprises honeysuckle, scutellaria baicalensis, radix bupleuri and periostracum cicada; the oral liquid comprises the traditional Chinese medicine formula. According to the traditional Chinese medicine formula, the concentration is 0.2-1.2g / mL. According to the traditional Chinese medicine formula provided by the invention, the contained traditional Chinese medicinal materials arefew, the proportion of the traditional Chinese medicinal materials is reasonable and accurate, fever and rash can be brought down quickly, and through extraction and purification, the quality index of the preparation is controlled accurately, so that the preparation has good inhibition effect on various virus and bacterial infection, has slight toxic and side effects and is stable in clinical effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine formula for treating hand, foot and mouth disease, an oral liquid, a preparation method and application thereof. Background technique [0002] Hand, foot and mouth disease (HFMD) is an infectious disease caused by enterovirus (EV), which mostly occurs in infants and young children. Complications such as myocarditis and meningoencephalitis may even endanger the life of the child. The disease is a severe infectious disease, and there are reports of the prevalence of the disease in most parts of the world. It was first reported in Canada in 1957, and it was first seen in Shanghai in 1981 in China. In 1983, there was an epidemic of hand, foot and mouth disease in Tianjin. Since March 2008, hand, foot and mouth disease has occurred in some areas of my country. The Ministry of Health issued a notice on May 2, 2008, including hand,...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/08A61P31/14A61K35/64
CPCA61K9/0095A61K36/233A61K36/355A61K36/539A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K35/63A61K2300/00
Inventor 汤云
Owner SUZHOU SCI&TECH TOWN HOSPITAL
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