Method and apparatus for determining proton treatment dosage and range by using proton induced thermoacoustic signals

Abstract

The invention discloses a method and a device for determining the proton treatment dosage and range by using proton induced thermoacoustic signals. The method includes: receiving a proton induced thermoacoustic signal through an ultrasonic sensor, and analyzing the proton induced thermoacoustic signal and extracting the travel time and waveform information; performing ray tracing on a propagationpath of the proton induced thermoacoustic signal in a body, and calculating the minimum travel time of a first arrival wave; using the perturbation method to determine a partial derivative matrix of the travel time to a position of a thermal sound source, and establishing an inversion equation; obtaining the position of the thermal sound source and a velocity model through iterative fitting; solving the problem of double coupling of thermal sound source position disturbance and velocity model disturbance by using the parameter separation method; further correcting the position of thermal soundsource and the velocity model that the proton induced thermoacoustic signal is propagated in human body through the disturbance; and determining the dosage and the range of proton treatment through aproton beam energy distribution relationship. The experimental results obtained by the invention not only save the running time but also ensure the positioning accuracy; and the method and the devicecan be widely applied in proton treatment.

Description

technical field [0001] The present invention relates to the field of medical physics, in particular to a method and equipment for determining the dose and range of proton therapy through proton-induced thermoacoustic signals. Background technique [0002] For a long time, tumors have seriously threatened people's health. At present, radiation therapy is one of the commonly used methods to control and treat tumors, but in the process of clinical radiation therapy, as the radiation enters the human body, the dose and the depth of the radiation decay exponentially, which makes the normal tissues or organs before and after the tumor Suffer varying degrees of impact, resulting in radiation reactions and damage. Proton therapy for tumors can effectively improve this situation, because the physical characteristics of the Bragg (Bragg) peak are formed during proton beam irradiation, so that a large amount of energy is deposited at the position of the Bragg peak and quickly deposite...

AI Technical Summary

Problems solved by technology

However, water is a homogeneous medium, and the propagation speed of sound waves in water is known, while the human body medium is inhomogeneous, and the speed model of sound waves propagating in the human body is unknown, so the method of the KC Jones team cannot be used in actual proton therapy used in

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