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Hemostatic material

A technology of hemostatic material and thrombin receptor, applied in the field of hemostatic material, can solve the problems of systemic thrombosis, no circulation antagonist and the like

Active Publication Date: 2018-09-04
BAXTER INT INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This patch has the disadvantage that the hemostatic agent it provides is easily released from the patch when in contact with the patient's bleeding area
This presents a potential risk of systemic thrombotic events, especially given the absence of circulating antagonists

Method used

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Embodiment

[0057] Advances in Inducing Local Hemostasis with a Synthetic Platelet-Activating Hydrogel Matrix

[0058]The examples of the present invention demonstrate the use of the present invention for safe and Local accelerated hemostasis. In this paper, it is demonstrated for the first time that TRAP platelet-activating peptides (such as TRAP6) can be covalently immobilized in a synthetic hydrogel matrix ( Figure 7 B) Used to control bleeding. With this hemostatic material, the hypothesis was tested that polymer-conjugated TRAP6 peptides could retain their activity on platelet activation while accelerating hemostasis in a safe, localized manner without systemic release of platelet activators. A water-soluble PVA-TRAP6 conjugate was designed as a polymeric model for platelet activation along with insoluble (cross-linked) PVA-TRAP6 hydrogel particles (PVA-TRAP6-P) for safe and locally accelerated hemostasis. These new polymer-peptide conjugates were prepared using highly efficient t...

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Abstract

Disclosed is a hemostatic material, wherein a thrombin receptor activating agent is covalently coupled to a biocompatible matrix.

Description

technical field [0001] The present invention relates to hemostatic materials and methods of making and using the materials. Background technique [0002] Uncontrolled bleeding remains the leading cause of death in trauma and surgical injuries [1] . Therefore, developing effective treatments to control bleeding has the most important clinical and social value. Over the past few decades, many hemostatic products have been developed [2] , including fibrin-based glues or sealants [3a,b] , zeolite powder [4a,b] , cross-linked gelatin matrix [5a,b] Wait. However, each of these products has its own limitations. Fibrin products have high cost, short shelf life and low mechanical strength [6] . Zeolite minerals cause severe burns and are not degradable [6] . The cross-linked gelatin matrix can stop bleeding within minutes only when combined with high doses of thrombin [7] . However, thrombin is unstable in solution due to autoproteolysis. High concentrations of thrombin...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/10
CPCA61L24/001A61L24/10A61L2400/04A61L24/0015A61L24/0073A61L2300/418A61L24/046
Inventor 秦晓华保罗·斯莱扎克海因茨·雷德尔
Owner BAXTER INT INC
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