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Azelaic acid gel agent as well as preparation method and application thereof

A technology of azelaic acid gel and azelaic acid, which is applied in the fields of pharmaceutical formulations, aerosol delivery, active ingredients of salicylic acid, etc., and can solve the problem of azelaic acid's heavy oily feeling, low content of effective substances, and large side effects and other problems, to achieve the effect of reducing physical and psychological pain, improving the cure rate, and low cost

Active Publication Date: 2018-09-21
CHENGDU JOY YOUNG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the cream-type azelaic acid has a relatively oily feel, poor air permeability, relatively large side effects, and low active substance content

Method used

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  • Azelaic acid gel agent as well as preparation method and application thereof
  • Azelaic acid gel agent as well as preparation method and application thereof
  • Azelaic acid gel agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0035] The preparation method of azelaic acid gel of the present invention comprises the steps:

[0036] a. Uniformly disperse ZEN in 1,3-propanediol and then mix it with water to obtain solution A;

[0037] b. Uniformly disperse azelaic acid in 1,3-propanediol and heat to 65-80°C to obtain solution B;

[0038] c. Uniformly disperse salicylic acid in 1,3-propanediol to obtain solution C;

[0039] d. Mix solution A, solution B and solution C, stir and mix at 55-65° C., and then cool to room temperature to obtain azelaic acid gel.

[0040] Wherein, there is no time sequence among step a, step b and step c, and step a, step b, or step c may be performed first, or these three steps may be performed simultaneously. Just mix solution A, solution B and solution C at the end and stir well.

[0041] The present invention also provides the application of the azelaic acid gel described in the present invention in the preparation of medicines for preventing or treating acne.

[0042]T...

Embodiment 1

[0050] Prepare azelaic acid gel as follows:

[0051] a. Uniformly disperse ZEN in 1,3-propanediol and then mix it with water to obtain solution A;

[0052] b. Uniformly disperse azelaic acid in 1,3-propanediol, heat to 75°C, and stir until transparent to obtain solution B;

[0053] c. Uniformly disperse salicylic acid in 1,3-propanediol to obtain solution C;

[0054] d. Mix solution A, solution B and solution C, stir and mix at 60°C, and then cool to room temperature to obtain azelaic acid gel.

[0055] Wherein, the formula of each raw material is shown in Table 1.

[0056] Table 1

[0057]

[0058] On the basis of this formula, a certain amount of bacteria (18000cfu / g or mold 8700cfu / g liquid) is artificially introduced, and then a quantitative sample is taken to measure its antibacterial effect. The results are shown in Table 2.

[0059] Table 2

[0060]

[0061] It can be seen from Table 2 that although no preservative is added to the system, it can still be anti...

Embodiment 2～4

[0063] Azelaic acid gel was prepared according to the method described in Example 1, wherein the total amount of each raw material is shown in Table 3.

[0064] table 3

[0065]

[0066] Measure the antibacterial property of above-mentioned product, find that the product of embodiment 2~4 also has antibacterial property.

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Abstract

The invention relates to an azelaic acid gel agent as well as a preparation method and application thereof, belonging to the technical field of skin medicines. The azelaic acid gel agent provided by the invention contains the following components in percentage by weight: 10%-20% of azelaic acid, 0.5%-2% of salicylic acid, 1%-3% of ZEN, 60%-74% of 1,3-propylene glycol and the balance of water. Thegel agent is prepared from azelaic acid by virtue of specific raw materials, is transparent, does not precipitate, is capable of well infiltrating skin and can be applied to the treatment or prevention of acnes, and the curing rate of patients with acnes can be increased; and the components are simple, the azelaic acid gel is capable of resisting bacteria without being added with a preservative, and the preparation method is simple, and the cost is low.

Description

technical field [0001] The invention relates to azelaic acid gel and its preparation method and application, belonging to the technical field of skin medicine. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit. It mainly occurs in adolescents and has a great psychological and social impact on adolescents, but it can often be relieved or cured naturally after puberty. The clinical manifestations are characterized by pleomorphic skin lesions such as acne, papules, pustules, and nodules that are prone to occur on the face. [0003] According to the joint survey of my country Dermatology Association and my country Youth Federation, the incidence of acne in my country is on the rise year by year, and more than 80% of people have encountered acne problems in varying degrees. The incidence of severe acne accounts for more than 1 / 3 of young people. Among them, there are 294 million middle school students with acne, 133 million coll...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/20A61K31/60A61K47/32A61K47/10A61P17/10
CPCA61K47/10A61K47/32A61P17/10A61K9/0014A61K9/06A61K31/20A61K31/60A61K2300/00A61K31/194
Inventor 王广基
Owner CHENGDU JOY YOUNG BIOTECH CO LTD
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