A method for removing pulse interference from liquid chromatography curve

Abstract

The invention discloses a method for removing pulse interference from a liquid chromatographic curve, comprising the steps of: collecting test data to establish a liquid chromatographic curve, performing segmental testing on the liquid chromatographic curve; calculating the mean value and variance of the liquid chromatographic curve in the test section , determine the median point and its corresponding value on the liquid chromatography curve; judge whether the median point is a pulse interference point, and obtain the pulse interference point; perform cubic spline interpolation and use the fitting method to replace the pulse interference point, and obtain The phase chromatogram curve of the liquid to remove the pulse interference. The invention removes the pulse interference before the automatic peak identification of the liquid chromatography curve, eliminates the pulse interference appearing in the liquid chromatography curve, and ensures the original state of the filtered data; the effect of removing the pulse interference is good, and the later peak identification is improved the accuracy.

Description

technical field [0001] The invention belongs to the technical field of pulse interference removal methods, in particular to a method for removing pulse interference from liquid chromatography curves. Background technique [0002] In the actual working environment, due to voltage instability, electromagnetic interference, circuit interference and other reasons, there will be pulse interference on the liquid chromatography curve. If the traditional sliding filter or maximum value filter is used for the pulse interference, it may cause its own normal data. The modification of the method will greatly reduce the accuracy of peak identification in the later stage. Contents of the invention [0003] In order to solve the above problems, the present invention proposes a method for removing pulse interference from liquid chromatography curves, which removes pulse interference before automatic peak recognition of liquid chromatography curves, eliminates pulse interference from liqui...

AI Technical Summary

Problems solved by technology

[0002] In the actual working environment, due to voltage instability, electromagnetic interference, circuit interference and other reasons, there will be pulse interference on the liquid chromatography curve. If the traditional sliding filter or maximum value filter is used for the pulse interference, it may cause its own normal data. Modifications, resulting in a significant reduction in the accuracy of peak identification in the later stage

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