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Application of type C Class I Niemann-Pick protein inhibitor

A technology for inhibiting proteins and inhibitors, which is applied in the field of type C type 1 Niemann-Pick protein inhibitors, and can solve the problems of limited diagnosis and treatment methods.

Inactive Publication Date: 2019-01-04
BEIJING PROTEOME RES CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The means of diagnosis and treatment are very limited

Method used

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  • Application of type C Class I Niemann-Pick protein inhibitor
  • Application of type C Class I Niemann-Pick protein inhibitor
  • Application of type C Class I Niemann-Pick protein inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Example 1. The high expression of NPC1 in liver cancer is closely related to the occurrence and prognosis of liver cancer

[0092] In order to confirm the high expression of NPC1 in liver cancer, the inventors used the liver cancer tissue chip (95 liver cancer / 85 matching paracancerous) to detect the significantly high expression of NPC1 in HCC ( figure 1 A, B), the overall survival of patients with high expression of NPC1 was significantly lower than that of

[0093] Patients with low expression of NPC1 ( figure 1 C). It is confirmed that NPC1 is closely related to the occurrence and prognosis of liver cancer.

Embodiment 2

[0094] Example 2, NPC1 inhibitors can inhibit the growth of liver cancer cells

[0095] In this example, the inventors studied the role of NPC1 inhibitors in inhibiting the growth of liver cancer cells.

[0096] The results showed that the NPC1 inhibitor U18666A could significantly inhibit the proliferation of liver cancer cells (HepG, MHCC97H, Huh7) ( figure 2 ). It shows that NPC1 can significantly inhibit the proliferation of liver cancer cell lines, suggesting that NPC1 may be used as a target for liver cancer treatment.

Embodiment 3

[0097] Example 3, NPC1 inhibitors can inhibit the growth of cancer cells

[0098] In this example, the inventors investigated the role of NPC1 inhibitors in the growth of common cancer cells.

[0099] The results showed that NPC1 inhibitor U18666A significantly inhibited common cancer cell lines (cervical cancer Hela cell line, colon cancer HCT116 cell line, non-small cell lung cancer A549 cell line, breast cancer MCF7 cell line, esophageal cancer ECA109 cell line and leukemia Jurkat cell line) Proliferation ( image 3 ). It shows that NPC1 can significantly inhibit the proliferation of cancer cell lines, suggesting that NPC1 may be used as a target for cancer therapy.

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Abstract

The invention discloses the use of a substance for inhibiting the gene expression and / or protein activity of type C ClassINiemann-Pick protein (NPC1). The use is selected from at least one of the group consisting of (a) a medicament for preventing and / or treating cancer; (b) the medicament for preventing and / or treating cancer diffusion metastasis; (c) the medicament for preparing apoptosis promoting cancer cells; (d) the medicament for preparing cancer-inhibiting cancer cells; (e) the medicament for preparing inhibition of the proliferation of cancer cells in vitro. The present inventors haveproved that Type C Class 1 Niemann-Pick protein (NPC1) is highly expressed in liver cancer tissues, and the abundance is high, and the prognosis of patients with liver cancer is poor. Type C Class-1Niemann Pick protein (NPC1) inhibitor can effectively inhibit the growth of human liver cancer and other tumor cells at the cell level, and can be used as a candidate medicine target for tumor, especially liver cancer.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a new application of a type C-type 1 Niemann-Pickin (NPC1) inhibitor. Background technique [0002] The liver is the center of cholesterol metabolism in the body and plays a vital role in maintaining the balance of cholesterol metabolism in the body. The liver can produce large amounts of cholesterol through de novo synthesis. Blood cholesterol levels are significantly positively correlated with the incidence of liver cancer. The level of intracellular cholesterol is very important to the life activities such as cell growth, proliferation and differentiation. Clinical studies have shown that serum cholesterol levels in patients with liver cancer are significantly reduced. However, the cholesterol level in liver cancer tissue was significantly higher than that in paracancerous tissue. Niemann-Pickin C-type 1 (NPC1) is a transmembrane glycoprotein containing a sterol-receptive domain i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/566A61K45/06A61P35/00A61P35/04
CPCA61K31/566A61K45/06A61P35/00A61P35/04A61K2300/00A61K31/7105C12Q1/6886C12Q2600/158G01N33/57492C12Q2600/118
Inventor 姜颖孙爱华贺福初李朝英周金安魏汉东王守乾
Owner BEIJING PROTEOME RES CENT
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