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Method, apparatus, device and medium for sample classification based on gene mutation information

A sample and gene technology, applied in the field of information processing, can solve problems such as not fully considering the complex relationship between genes, poor classification effect, and lack of biological significance in classification methods, so as to achieve the effect of optimizing sample classification methods and improving classification accuracy

Inactive Publication Date: 2019-03-01
SHANGHAI BIOTECAN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the process of realizing the present invention, the inventor found that the existing technology has the following defects: the existing sample classification technology does not fully consider the complex relationship between genes, the classification method lacks biological significance, and the classification effect is poor

Method used

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  • Method, apparatus, device and medium for sample classification based on gene mutation information
  • Method, apparatus, device and medium for sample classification based on gene mutation information
  • Method, apparatus, device and medium for sample classification based on gene mutation information

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Embodiment 1

[0031] Figure 1a It is a flowchart of a method for classifying samples according to gene mutation information provided by Embodiment 1 of the present invention. This embodiment is applicable to the case of classifying samples according to an expanded set of mutant genes. The method can be based on gene mutation information The apparatus for classifying samples can be implemented by means of software and / or hardware, and can generally be integrated into computer equipment. Correspondingly, such as Figure 1a As shown, the method includes the following operations:

[0032] S110. Acquire mutant gene sets respectively corresponding to at least two samples to be classified, and expand associated genes for each of the mutant gene sets according to the inter-gene relationship diagram.

[0033] Wherein, the sample to be classified may be a user sample including a mutated gene in vivo for genetic research, and the embodiment of the present invention does not limit the type and positio...

Embodiment 2

[0058] figure 2 It is a flow chart of a method for classifying samples according to gene mutation information provided by Embodiment 2 of the present invention. This embodiment is embodied on the basis of the above-mentioned embodiments. A specific implementation manner of expanding the associated genes to the mutated gene set. Correspondingly, such as figure 2 As shown, the method of this embodiment may include:

[0059] S210. Acquire mutant gene sets respectively corresponding to at least two samples to be classified, and expand associated genes for each of the mutant gene sets according to the inter-gene relationship diagram.

[0060] Correspondingly, S210 may specifically include the following operations:

[0061] S211. Obtain a target mutant gene from the currently processed mutant gene set.

[0062] Wherein, the target mutation gene can be any mutation gene in the mutation gene set.

[0063] In the embodiment of the present invention, the expansion operation of th...

Embodiment 3

[0084] Figure 3a It is a flowchart of a method for classifying samples according to gene mutation information provided by Embodiment 3 of the present invention. This embodiment is embodied on the basis of the above-mentioned embodiments. In this embodiment, it is given to divide the merged results into A mutation gene classification set corresponding to at least two sample categories respectively, and a specific implementation manner of classifying the samples by using the mutation gene classification set. Correspondingly, such as Figure 3a As shown, the method of this embodiment may include:

[0085] S310. Acquire mutation gene sets respectively corresponding to at least two samples to be classified, and expand associated genes for each of the mutation gene sets according to the inter-gene relationship diagram.

[0086] S320. Merge the expanded mutant gene sets, and divide the merged result into mutant gene classification sets corresponding to at least two sample categori...

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Abstract

The invention discloses a method, an apparatus, a device and a medium for sample classification based on gene mutation information. The method comprises the steps that mutated gene sets correspondingto at least two samples to be classified are obtained, and expansion of associated gene is conducted on the mutated gene sets based on a gene relation pattern; the expanded mutated gene sets are merged, and the merging result is divided into mutated gene classification sets, respectively corresponding to at least two sample types; the mutated gene classification set is adopted to conduct classification on the sample. The invention is advantageous in that the current sample classification mode based on mutated gene can be optimized, and thereby classification accuracy can be improved.

Description

technical field [0001] Embodiments of the present invention relate to information processing technology, and in particular to a method, device, equipment and medium for classifying samples according to gene mutation information. Background technique [0002] Gene mutation refers to the sudden and heritable variation of genomic DNA (deoxyribonucleic acid) molecules. Errors in the gene replication process, or under the influence of physical, chemical or biological factors, lead to changes in the gene sequence. This gene sequence change has many forms, such as point mutation (single base deletion), multiple Base deletions, duplications, or insertions, etc. [0003] Gene mutations are often directly or indirectly related to certain diseases (eg, tumors). In the prior art, samples, especially samples of diseased users, can be classified according to the mutated gene types of different samples. At present, the method of classifying samples based on mutated genes is mainly to us...

Claims

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Application Information

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IPC IPC(8): G16B20/50G16B40/20
Inventor 高军晖王丽君袁卫兰张英霞龚建兵赵伟林灵
Owner SHANGHAI BIOTECAN PHARMA
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