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Purpose of histone demethylase KDM6A inhibitor to preparation of obesity treatment medicines

A demethylase and therapeutic drug technology, applied in the biological field, can solve the problems that KDM6A's physiological role has not been reported yet, and achieve the effect of reducing leptin resistance and suppressing stress levels

Active Publication Date: 2019-04-02
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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Problems solved by technology

[0004] However, the physiological role of KDM6A in other human pathological conditions such as obesity has not been reported

Method used

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  • Purpose of histone demethylase KDM6A inhibitor to preparation of obesity treatment medicines
  • Purpose of histone demethylase KDM6A inhibitor to preparation of obesity treatment medicines
  • Purpose of histone demethylase KDM6A inhibitor to preparation of obesity treatment medicines

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Embodiment 1

[0063] Example 1 The effect of KDM6A deficiency on the body weight of diet-induced obesity (DIO) mice

[0064] In view of the relationship between endoplasmic reticulum stress and obesity, in order to study the potential physiological effects of KDM6A in vivo, we established inducible knockout mice and selected a high-fat diet-induced obesity model. The mouse histone demethylation The NCBI accession number of the enzyme Kdm6a is: NM_009483.

[0065] 1.1 Experimental animals

[0066] Kdm6a f / f (1) (The Jackson Laboratory Deposit No. 024177, USA) and UBC-Cre / ERT2(2) (Jackson Laboratory Deposit No. 007179, USA) two mouse strains were previously reported. Both strains of mice were backcrossed with C57 wild-type mice for more than 10 generations. Kdm6a iKO / Y The mice were bred from the above two strains and used PCR reaction to identify the genotype. The mice can inductively knock out the Kdm6a gene in the whole body after receiving tamoxifen injection. The mice were kept at 22°C in ...

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Abstract

The invention provides a purpose of a histone demethylase KDM6A inhibitor to preparation of obesity treatment medicines. The histone demethylase KDM6A inhibitor provided by the invention can restrainthe activity of histone demethylase KDM6A, further can restrain expression of genes relevant to endoplasmic reticulum stress, and can reduce leptin resistance, so that obesity is treated.

Description

Technical field [0001] The present invention relates to the field of biotechnology, in particular to the use of a histone demethylase KDM6A inhibitor in the preparation of obesity treatment drugs. Background technique [0002] The prevalence of obesity is increasing year by year in the world. Studies have reported that 1 / 3 of people in the United States are obese. Obesity is an important risk factor for many chronic non-communicable diseases such as type 2 diabetes, cardiovascular disease and certain tumors, which seriously endanger human health. The FDA recently approved two new weight-loss drugs aimed at reducing energy intake by suppressing appetite. On the other hand, increasing energy expenditure to interfere with obesity has attracted more and more attention from clinicians and basic researchers. Finding factors related to energy expenditure has become a new hot spot in obesity intervention research. [0003] The lysine demethylase 6 (KDM6) family of histone demethylases co...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P3/04
CPCA61K45/00A61P3/04
Inventor 王旭陈万涛韦严
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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